2,467 results match your criteria: "Verrucous Carcinoma"

Article Synopsis
  • Giant condyloma accuminata, also known as Buschke-Lowenstein tumor, is a rare and large growth resembling a cauliflower, typically found in the anogenital area, and relates to HPV infections.
  • The tumor exists on a spectrum between typical condylomas and squamous cell carcinoma, often resulting in surgical treatment due to its tendency to infiltrate soft tissue and recur.
  • The case presented involves a 40-year-old male with cystic fibrosis who developed this tumor without any known HPV or common risk factors, and he was treated through near-total surgical resection.
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A case report of squamous cell carcinoma mimicking interdigital intertrigo.

Oxf Med Case Reports

July 2024

Department of Dermatology and Venereology, Mohammed VI University Hospital, M3MF+GCG, La Nouvelle Ville Ibn Batouta, Tangier, Morocco.

Article Synopsis
  • Squamous cell carcinoma (SCC) is a common type of skin cancer that can affect the nails, exemplified by a 60-year-old male patient who developed a painful ulcer in his foot due to a prior misdiagnosis of a fungal infection.
  • Dermatological examination showed characteristics of SCC, and although the initial biopsy indicated keratoacanthoma, it did not reveal malignant features, leading to the eventual identification of moderately differentiated SCC in a follow-up biopsy.
  • Successful surgical resection was performed to treat the SCC, highlighting the importance of accurate pathology understanding and biopsy techniques in preventing progression of this form of skin cancer.
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Article Synopsis
  • A 71-year-old male presented with a mass in his scrotum that had been growing slowly and was not painful.
  • A physical exam showed a soft, brown tumor measuring 4.5×3.5×3.0 cm, with lab tests indicating elevated blood sugar and a squamous carcinoma marker.
  • The tumor was removed surgically, and no cancer was found; it was diagnosed as giant condyloma acuminatum, which often occurs in people with weakened immune systems.
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Traversing the Terrain: Potential Pitfalls within the AJCC 8th Edition Staging System for Lip and Oral Cavity Cancers.

Head Neck Pathol

July 2024

Department of Oncopathology, Malabar Cancer Centre (PGIOSR), Kodiyeri, Muzhikkara - MCC Rd, Illathaazha, Thalassery, Kerala, 670103, India.

Article Synopsis
  • In 1977, the AJCC launched the first Cancer Staging Manual using a T (tumor size), N (lymph node involvement), and M (metastasis) system to help clinicians plan treatments and predict outcomes for various cancers.
  • * The AJCC 8th edition, effective January 1, 2018, continues this approach, but it has identified issues in staging certain types of cancers, particularly in accurately assessing oral squamous cell carcinoma and minor salivary gland tumors.
  • * There is a need for improvements in staging guidelines for various specific tumors, including malignant odontogenic tumors and those affecting the ear and bone, along with diagrammatic aids to enhance understanding.*
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Many faces of cutaneous leishmaniasis.

Postgrad Med J

September 2024

Department of Medical Microbiology, Harran University Medical Faculty, Şanlıurfa 63000, Turkey.

Article Synopsis
  • This study aimed to identify atypical clinical presentations of cutaneous leishmaniasis (CL) in Şanlıurfa province, encompassing a retrospective analysis of 213 patients with non-standard symptoms out of 1,751 diagnosed cases between 2019 and 2022.
  • The prevalence of atypical CL was found to be 12.1%, with common atypical lesions including lupoid, erysipeloid, and impetiginous types, along with many others resembling various skin conditions and diseases.
  • The research highlights that CL can mimic a wide range of infectious, inflammatory, and neoplastic disorders, stressing the importance of thorough differential diagnosis for persistent non-healing skin lesions, especially in areas where CL is
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Plasmoacanthoma of Lip-A Rare Case with Review of Literature.

Indian J Otolaryngol Head Neck Surg

June 2024

Department of ENT and Head and Neck Surgery, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India.

Article Synopsis
  • Plasmoacanthoma is a rare, benign verrucous lesion that can easily be misdiagnosed as squamous cell carcinoma, creating challenges for both clinicians and pathologists.
  • A case study details a 70-year-old female with a lower lip lesion that resembled cancer, but biopsy and histopathology confirmed it as plasmoacanthoma after initial treatment with corticosteroids failed.
  • A review of existing literature highlighted the importance of understanding the distinct features and similarities of plasmoacanthoma and related conditions to improve diagnosis and management strategies.
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Article Synopsis
  • Proliferative verrucous leukoplakia (PVL) is distinct from other oral leukoplakias (OLs) in its clinical behavior, and this study aimed to identify molecular differences through DNA methylation analysis.
  • A genome-wide analysis revealed 1,815 differentially methylated CpGs between PVL and homogeneous leucoplakia (HL), with HL showing hypermethylation and involvement of genes related to cancer prognosis.
  • The research developed a logistic regression model that can differentiate between PVL, HL, and healthy samples, highlighting the potential for using methylation patterns as diagnostic biomarkers for oral lesions.
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Article Synopsis
  • A 75-year-old man had a painless, enlarging skin tumor on his abdomen that he had for 30 years.
  • The tumor appeared brownish with a warty surface, raising concerns that it could be a melanocytic tumor or verrucous carcinoma.
  • After surgical removal, pathology confirmed that the mass was actually a giant seborrheic keratosis, a benign growth.
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Article Synopsis
  • Verrucous carcinoma is a low-grade type of squamous cell carcinoma found mainly in the oral cavity but also appears in areas like the larynx, esophagus, and genitals; it’s linked to chronic irritation and carcinogenic factors like HPV, smoking, and alcohol.
  • * The occurrence of verrucous carcinoma in the chin area is extremely rare, which makes the case described in the text unique, with other unusual locations reported being fingers and feet.
  • * Although generally not aggressive in spreading, if not surgically removed completely, these tumors can recur and become more aggressive; the treatment typically involves wide surgical excision for a better prognosis.*
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Hereby, we present a rare case of malignant transformation in a long-standing case of pseudoepitheliomatous keratotic and micaceous balanitis (PKMB), which typically affects older men. PKMB presents as whitish or silvery keratotic plaques on the glans and can remain stable for years, leading to potential confusion regarding its progression. The patient in this case experienced urinary obstruction due to tumorous ingrowth, prompting an investigation.

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Verrucous carcinoma presenting as recalcitrant verruca plantaris.

Dermatol Online J

March 2024

Division of Dermatology, University of Vermont, Burlington, Vermont, USA.

Article Synopsis
  • Verrucous carcinoma (VC) is a rare and low-grade type of squamous cell carcinoma that typically appears as a slow-growing, wart-like growth on the soles of the feet, particularly in areas of weight bearing.
  • A patient had a 20-year history of a potentially misdiagnosed, ulcerated verrucous plaque on their foot that was initially treated as a common wart but was later found to be invasive verrucous carcinoma.
  • Accurate diagnosis is crucial since these carcinomas can mimic benign growths, and Mohs micrographic surgery is recommended to ensure proper removal while preserving healthy tissue; delays in treatment can lead to more severe interventions like dissection or amputation.
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Genome-wide characterization of the mutational landscape of proliferative verrucous leukoplakia.

Oral Surg Oral Med Oral Pathol Oral Radiol

July 2024

Australian Centre for Oral Oncology Research & Education, Nedlands WA, Australia; UWA Dental School, University of Western Australia, Nedlands WA, Australia.

Article Synopsis
  • - The study focuses on proliferative verrucous leukoplakia (PVL), a rare and aggressive condition that often turns into oral squamous cell carcinoma (OSCC), aiming to uncover genetic mutations involved in its progression.
  • - Researchers conducted whole exome sequencing on biopsies from patients diagnosed with PVL, finding mutations in several cancer-related genes and significant pathways like NOTCH and Hippo being commonly affected.
  • - The results point to both established and new potential mechanisms driving the cancerous changes seen in PVL, highlighting the importance of genetic analysis in understanding this condition.
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Oral Carcinoma Arising Under Implant-Supported Prosthesis: Progression of Proliferative Verrucous Leukoplakia Initially Mimicking Lichen Planus.

J Oral Implantol

August 2024

Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Ribeirão Preto, SP, Brazil.

Article Synopsis
  • Proliferative verrucous leukoplakia (PVL) is a type of oral leukoplakia known for its recurring white plaques and risk of turning cancerous.
  • A 52-year-old woman was initially misdiagnosed with oral lichen planus (OLP), but after further examination, she was correctly identified as having early-stage PVL.
  • Six years after receiving dental implants, she developed squamous cell carcinoma, highlighting the need for careful monitoring in PVL patients with oral lesions near implants.
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Clinical, Radiological, and Pathological Correlation of Mandibular Invasion in Carcinoma Bucco-alveolar Complex.

Indian J Surg Oncol

June 2024

Department of Otorhinolaryngology-Head and Neck Surgery, AIIMS, Raipur, Chhattisgarh India.

Article Synopsis
  • A prospective study analyzed 64 oral cancer patients to determine the relationship between clinical, radiological, and pathological findings concerning mandibular invasion.
  • The study found oral cancer to be more common in males, with clinical evaluations effectively predicting mandible involvement; CT scans had high sensitivity while Orthopantomograms showed excellent specificity.
  • Despite advances in imaging and technology, accurately measuring bone invasion remains difficult, yet CT and MRI are valuable tools alongside clinical assessments for evaluating mandibular invasion in oral cancers.*
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Introduction And Importance: Buschke-Löwenstein tumor (BLT) is a rare perianal lesion caused by low-risk mucosal HPV 6 or 11 but less frequently associated with high-risk HPV types. It is a large, exophytic, verrucous lesion of the anogenital region. BLT presents as a benign tumor but exhibits malignant clinical behavior and has a high rate of local recurrence and malignant transformation.

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Classificatory updates in verrucous and cuniculatum carcinomas: Insights from the 5 edition of WHO-IARC head and neck tumor classification.

World J Clin Oncol

April 2024

Department of Diagnostics in Oral Pathology and Oral Medicine, Faculty of Dentistry, Universidad de la República, Montevideo 1600, Uruguay.

The International Agency for Research on Cancer (IARC) and World Health Organization (WHO) collaboratively produce the 'WHO Blue Books' essential tools standardizing the diagnostic process for human cancers. Regular updates in this classification accommodate emerging molecular discoveries, advances in immunohistochemical techniques, and evolving clinical insights. The 5 edition of the WHO/IARC classification of head and neck tumors refines the 'Oral Cavity and Mobile Tongue' chapter, including sections for non-neoplastic lesions, epithelial tumors, and tumors of uncertain histogenesis.

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Proliferative verrucous leukoplakia (PVL) is an oral mucosa lesion with a high rate of malignant transformation. The diagnosis is often difficult, especially when the initial lesion is a simple homogeneous white leukoplakia, and when located only on the gingiva or palate. Moreover, the anatomopathological analysis is non-specific in the initial stages.

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Fine scalpel surgery: preserving the dartos muscle in a patient with scrotal and perigenital giant Buschke-Löwenstein tumors.

Wien Med Wochenschr

November 2024

Onkoderma-Clinic for Dermatology, Venereology and Dermatologic Surgery, General Skobelev 26, 1606, Sofia, Bulgaria.

Giant condyloma acuminatum (GCA), alternatively referred to as a Buschke-Löwenstein tumor (BLT), is an uncommon, benign, but locally aggressive form of verrucous carcinoma. The condition usually affects the male population under the age of 50 years; however, there have been rare reports of pediatric cases. Various risk factors such as smoking, diabetes, promiscuous behavior, poor hygiene, immunosuppression, and others are linked to the development of this condition.

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Article Synopsis
  • A 23-year-old South Asian man developed a darkly pigmented papule on his scalp, which grew within a pre-existing warty plaque present since birth.
  • The papule showed characteristics indicative of basal cell carcinoma (BCC) when examined and biopsied, confirming it developed from a sebaceous naevus.
  • Sebaceous naevi are benign skin lesions that can develop into malignancies like BCC in a small percentage of cases, especially in adults.
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Conventional obturator prostheses might cause dissatisfaction in patients with hard or soft palate defects due to inadequate retention and function during speech, mastication, and swallowing. Thus, surgical reconstruction and implant-supported obturators are considered as alternative treatments for these patients. This case-report study describes the prosthetic reconstruction of an 88-year-old patient suffering from a hard palate defect after surgical resection of verrucous carcinoma in the left side of the hard palate.

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Squamous cell carcinoma is a common malignant condition affecting the oral cavity and may involve the surrounding maxillofacial regions. Treatment commonly involves resection of the tumor, followed by prosthetic rehabilitation of the resection defect. This clinical report presents a 62-year-old Asian male patient who had previously undergone surgical resection, resulting in a post-surgical Aramany Class II maxillary defect.

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