2,467 results match your criteria: "Verrucous Carcinoma"
Demographic and clinicopathological comparison among oral lichen planus, lichenoid lesions and proliferative verrucous leukoplakia: a retrospective study.
BMC Oral Health
December 2024
Dental Sciences Graduate Program. Federal University of Espirito Santo (UFES), Avenida Maruípe 1468, Maruípe, Vitória, 29040-090, ES, Brazil.
Background: Clinicopathological diagnosis and follow-up of oral lichen planus and leukoplakia are necessary due to its potential for malignant transformation and the need to differentiate it from other lichenoid diseases and proliferative verrucous leukoplakia. This study aimed to classify and compare sociodemographic and clinicopathological features among patients with oral lichen planus, oral lichenoid lesions and proliferative verrucous leukoplakia.
Methods: A transversal observational study in which oral leukoplakia and oral lichen planus patients were surveyed at the Oral Pathological Anatomy Service and Applied Biotechnology Laboratory was conducted.
Considering SOD and miRNA analysis as potential prognostic markers in white lesion malignant transformation: A report of two cases.
Medicine (Baltimore)
December 2024
Department of Medical Biology, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Košice, Slovak Republic.
Rationale: Predictive biomarkers can be effective in the identification of the oral leukoplakia with an increased probability of malignant transformation.
Patients Concerns: A 63-year-old patient presents with persistent burning sensations throughout the oral cavity, accompanied by a white lesion on the tongue. Additionally, a 57-year-old patient with multiple white lesions in the oral cavity.
Photodynamic therapy with hematoporphyrin derivative for the treatment of penile verrucous carcinoma: A case report.
Photodiagnosis Photodyn Ther
December 2024
The Fifth People's Hospital of Hainan Province,Haikou City, Hainan Province, China. Electronic address:
Verrucous carcinoma, a well-differentiated variant of squamous cell carcinoma with low-grade malignancy, is often associated with localized human papillomavirus (HPV) infection and excessive penile foreskin. We report a 45-year-old male who presented with a verrucous plaque on the glans penis for over four months, along with itching. Examination revealed a verrucous, erosive lesion with a cauliflower-like surface, firm texture, and irregular shape, accompanied by pain, bleeding, and a foul odor.
View Article and Find Full Text PDFEradication of proliferative verrucous leukoplakia with toll-like receptor 7 agonist (topical imiquimod): a case report.
Front Oncol
November 2024
Department of Otolaryngology-Head & Neck Surgery, Medical University of South Carolina, Charleston, SC, United States.
Article Synopsis
Identification of new tissue markers for the monitoring and standardization of penile cancer according to the degree of differentiation.
Histol Histopathol
November 2024
Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, Network Biomedical Research Center for Liver and Digestive Diseases (CIBEREHD), University of Alcalá, Alcala de Henares, Spain.
Article Synopsis
- - Penile cancer is a rare type of tumor, more frequently seen in low- and middle-income countries, with major risk factors being age, ethnicity, smoking, hygiene, and HPV infection.
- - Early detection can lead to high cure rates (up to 80%), but late diagnosis significantly lowers survival chances, especially when the cancer has spread.
- - The study assesses various biomarkers related to cell growth, inflammation, and other processes in penile squamous cell carcinoma, suggesting that the degree of cell differentiation affects these biomarkers' expression, which may help in predicting disease outcomes.
Epidemiological and Histopathological Features of Oral Squamous Cell Carcinoma-A Retrospective Study.
Curr Health Sci J
September 2024
Department of Neurosurgery, University of Medicine and Pharmacy of Craiova, Romania.
Article Synopsis
- Oral Squamous Cell Carcinoma (OSCC) is the 6th most common malignant tumor globally, with a high rate of morbidity and mortality, particularly affecting men over 50 years old.
- A study conducted from 2009 to 2019 examined 50 cases of OSCC, revealing that the tongue is the most commonly affected site, with conventional OSCC making up 70% of the cases.
- The study found a high prevalence of muscle invasion (70%) and perineural invasion (38%), with most tumors diagnosed at advanced stages, particularly focusing on age-related patterns in tumor development.
Histopathological Variants of Oral Squamous Cell Carcinoma Operated at a Cancer Institute in North India.
Indian J Surg Oncol
December 2024
Khandelwal Dental Clinic and Implant Center, Noida, Uttar Pradesh India.
Conventional oral squamous cell carcinoma (OSCC) is one of the most common cancers of the head and neck region. However, histopathological variants of conventional oral squamous cell carcinoma also exist, which range from highly aggressive to those with good prognosis. Here, we present a case series of different histopathological variants of conventional OSCC treated at our institute.
View Article and Find Full Text PDFPrognostic implications across histological subtypes of head and neck squamous cell carcinoma: An update.
J Stomatol Oral Maxillofac Surg
November 2024
Department of Pathology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil. Electronic address:
Article Synopsis
- * This review examines existing research on the prognostic implications of HNSCC’s histopathologic subtypes, noting a lack of studies focusing specifically on treatment outcomes for each subtype.
- * The review highlights that some subtypes, like verrucous and cuniculatum, have better prognoses compared to others like basaloid and spindle cell, and it emphasizes the need for more molecular research to develop targeted therapies and improve prognostic assessments.
Clinicopathologic Features of Oral Verrucous Carcinoma: A Systematic Review and Meta-Analysis.
Ann Otol Rhinol Laryngol
November 2024
Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, Commonwealth Healthcare Corporation, Saipan, MP, USA.
Objective: To further characterize the clinicopathologic features of oral verrucous carcinoma.
Methods: In accordance with PRISMA guidelines, a systematic review of the Medline, Web of Science, Embase, and Cochrane databases was performed in search of articles evaluating clinicopathologic features of oral verrucous carcinoma. Primary outcomes of interest included tumor subsites, T-staging, rates of cervical lymph node metastases, rates of distant metastases, 5-year survival (overall, disease-free, or disease-specific), and recurrence rates.
Diagnosis and Management of Malignant Epithelial Nail Unit Tumors.
Diagnostics (Basel)
October 2024
Dermatology Department, Saint Pierre and Brugmann University Hospitals, Université Libre de Bruxelles, 1000 Brussels, Belgium.
Article Synopsis
- Malignant tumors of the nail unit, like squamous cell carcinoma and basal cell carcinoma, can be hard to diagnose because they often look like benign issues, making early detection important.
- * This review examines various types of malignancies affecting the nail unit, discussing their clinical features, pathology, and surgical management challenges.
- * Proper evaluation and treatment strategies are critical for improving patient outcomes and preserving nail function during surgery.*
Beyond the Surface: A Case Report of Verrucous Carcinoma in a Young Female.
Cureus
September 2024
Obstetrics and Gynaecology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Article Synopsis
Proliferative verrucous leukoplakia: Case study of 24 years and outcome of treatment with CO laser.
Clin Adv Periodontics
October 2024
Department of Oral Pathology, Radiology and Medicine, School of Dentistry, University of Missouri-Kansas City, Kansas City, Missouri, USA.
Article Synopsis
The conundrum of the giant condyloma: is it carcinoma?
J Surg Case Rep
October 2024
Department of General Surgery, Virginia Mason Franciscan Health, 1100 9th Ave, Seattle, WA 98101, United States.
Article Synopsis
Evaluation of Tumor-Associated Macrophages and Micro-Vessel Density in Verrucous Carcinoma and Squamous Cell Carcinoma of the Oral Cavity.
Adv Biomed Res
August 2024
Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.
Background: Tumor-associated macrophages (TAMs) are a crucial cellular component of human tumors, but their exact roles in tumor growth and angiogenesis during cancer progression are still subject to debate. The present study aimed to explore the impact of TAMs on tumor progression and angiogenesis in oral squamous cell carcinoma (OSCC) and oral verrucous carcinoma (OVC).
Materials And Methods: For this cross-sectional study, 60 samples consisting of 40 OSCC and 20 OVC samples were chosen.
Evaluation of VEGF, BDNF, TRKB expression in oral epithelial dysplasia, oral verrucous carcinoma and oral squamous cell carcinoma and their role as prognostic indicator.
J Cancer Res Ther
July 2024
Department of Oral Pathology, Vivekanandha Dental College for Women, Tamil Nadu, India.
Article Synopsis
Gingival Proliferative Verrucous Leukoplakia and Cancer: A Systematic Review With Meta-Analysis.
Oral Dis
October 2024
Department of Odontology, Health Faculty, Université Paris Cité, Montrouge, France.
Article Synopsis
Integrating Mcm-2 and Ki-67 immunohistochemistry with clinico-pathologic parameters for enhanced prognostic accuracy in oral verrucous lesions.
J Stomatol Oral Maxillofac Surg
September 2024
Department of Oral and Maxillofacial Pathology, College Of Dental Sciences, Davangere, Karnataka 577004, India.
Article Synopsis
- Oral verrucous lesions (OVLs) are challenging to diagnose due to varying histopathological features, and this study investigates Mcm-2 and Ki-67 as markers to help differentiate these lesions from oral squamous cell carcinoma (OSCC).
- Using 90 paraffin-embedded tissue samples, the researchers assessed the expression levels of Mcm-2 and Ki-67, alongside patient survival data, employing statistical methods for analysis.
- Findings revealed that Mcm-2 is a more sensitive and prognostic indicator than Ki-67, with higher overexpression in verrucous lesions and improved survival rates in verrucous squamous cell carcinoma (VSCC) compared to conventional OSCC, suggesting its potential for better diagnosis
Differences in the landscape of colonized microorganisms in different oral potentially malignant disorders and squamous cell carcinoma: a multi-group comparative study.
BMC Microbiol
September 2024
Department of Oral Pathology, National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Peking University School and Hospital of Stomatology, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China.
Article Synopsis
- The study focuses on the role of oral microbiota in oral potentially malignant disorders (OPMDs), gathering samples from patients with different conditions to understand their microbial communities.
- Researchers analyzed oral biopsies from patients with various lesions and identified significant differences in microbial richness and diversity, particularly noting that olk showed the highest richness while PVL-SCC was similar to controls.
- The findings indicate that each disorder has unique dominant bacterial species, providing insights into the disease mechanisms and potential avenues for future research.
Potential of photodynamic therapy as a minimally invasive treatment for oral verrucous carcinoma.
Photodiagnosis Photodyn Ther
October 2024
Electrodiagnosis Department, Jilin FAW General Hospital, Jilin University, Changchun, PR China.
Article Synopsis
- - Oral verrucous carcinoma (OVC) and proliferative verrucous leukoplakia (PVL) may originate similarly and pose an increased risk of cancer when they occur together, especially in older patients.
- - Photodynamic therapy (PDT) is a non-invasive treatment option that uses light to activate substances that target and destroy malignant cells, offering a safer treatment method for those with these conditions.
- - In a case study, an elderly patient with both PVL and OVC underwent PDT, resulting in complete remission with no recurrence after 10 months, while maintaining good oral appearance and function.
Dermoscopic features of papillated Bowen's disease.
JAAD Case Rep
September 2024
Pathology Department, Institute of Oncology, Fundación Arturo López Pérez (FALP), Santiago, Chile.
Verrucous Carcinoma of the Foot: A Single Canadian Center Experience on Diagnosis, Management, and Outcomes.
Ann Plast Surg
September 2024
From the Section of Plastic Surgery, Department of Surgery, University of Manitoba, Winnipeg, MB, Canada.
Article Synopsis
- Verrucous carcinoma (VC) is a slow-growing, low-grade skin cancer that typically appears wart-like and commonly affects the oral cavity, anogenital region, and plantar surfaces, leading to diagnostic challenges due to its benign appearance.
- This study reports on six cases of plantar VC excised between 2014-2023, all of whom experienced recurrence despite initially negative margins.
- The findings suggest that aggressive surgical intervention is necessary for effective management of plantar VC, as repeated operations often lead to eventual amputation due to recurring lesions.
New potential diagnostic markers for verrucous hyperplasia and verrucous carcinoma based on RNA-sequencing data.
Mol Cell Probes
October 2024
Department of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju, 61186, Republic of Korea; Hard-Tissue Biointerface Research Center, School of Dentistry, Chonnam National University, Gwangju 61186, Republic of Korea. Electronic address:
Article Synopsis
- Verrucous carcinoma (VC) is a rare, low-grade type of squamous cell carcinoma that doesn't metastasize, making it different from invasive squamous cell carcinoma (SCC).
- Distinguishing VC from a benign condition called verrucous hyperplasia (VH) is difficult due to their similar appearance and clinical features.
- Researchers generated RNA profiling data from patients to identify new diagnostic markers, revealing specific mRNAs and long non-coding RNAs that could help differentiate between VH and VC, potentially improving treatment decisions.
A Bibliometric and Visualised Analysis of Proliferative Verrucous Leucoplakia From 2003 to 2023.
Int Dent J
July 2024
Hunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Centre of Oral Care & Hunan Clinical Research Centre of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxillofacial and Regenerative Medicine & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, Hunan, China. Electronic address:
Article Synopsis
- Proliferative verrucous leucoplakia (PVL) is a rare but aggressive oral lesion with a significant risk of malignant transformation, prompting the need for thorough bibliometric analysis of global research on the topic.
- This study aimed to evaluate the academic output, impact, and collaboration patterns related to PVL by analyzing publication data over the last 20 years.
- Findings revealed a slow but steady increase in publications, with significant contributions from the USA, Spain, and UK, and highlighted key authors and prominent keywords in the field.
[Interpretation of "Proliferative verrucous leukoplakia: an expert consensus guideline for stadardized assessment and reporting"].
Zhonghua Kou Qiang Yi Xue Za Zhi
July 2024
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine & Clinical Research Center for Oral Diseases of Zhejiang Province & Key Laboratory of Oral Biomedical Research of Zhejiang Province & Cancer Center of Zhejiang University, Hangzhou 310006, China.
Article Synopsis
- Proliferative verrucous leukoplakia (PVL) is an oral condition known for its high rates of recurrence and potential to develop into cancer.
- In 2021, expert organizations laid out new guidelines categorizing PVL into four distinct types to aid in better understanding and treatment.
- The aim of the paper is to clarify these categories and provide guidance for clinical diagnosis and treatment of PVL.