1 results match your criteria: "Venerology and Allergology Medical University of Gdansk Gdansk Poland.[Affiliation]"
DNA methylation profile in patients with indolent systemic mastocytosis.
Clin Transl Allergy
November 2021
Department of Dermatology, Venerology and Allergology Medical University of Gdansk Gdansk Poland.
Article Synopsis
- Mastocytosis is a diverse, often acquired disease of mast cells, primarily driven by a specific mutation (KIT D816V) that influences its severity and treatment approaches.
- This study aimed to examine the connection between symptoms of mastocytosis and epigenetic changes, seeking to find potential epigenetic markers that could predict disease progression.
- Results showed a notable decrease in DNA hydroxymethylation (5-hmC) in patients with indolent systemic mastocytosis compared to healthy individuals, suggesting epigenetic changes are linked to the condition, although other methylation markers were not statistically significant.