Gene expression and hormonal signaling in osteoporosis: from molecular mechanisms to clinical breakthroughs.

Osteoporosis is well noted to be a universal ailment that realization impaired bone mass and micro architectural deterioration thus enhancing the probability of fracture. Despite its high incidence, its management remains highly demanding because of the multifactorial pathophysiology of the disease. This review highlights recent findings in the management of osteoporosis particularly, gene expression and hormonal control.

Mycoremediation of heavy metals by Curvularia lunata from Buckingham Canal, Neelankarai, Chennai.

The spread and mobilization of toxic heavy metals in the environment have increased to a harmful level in recent years as a result of the fast industrialization occurring all over the world to meet the demands of a rising population. This research aims to analyze and evaluate the mycoremediation abilities of fungal strains that exhibit tolerance to heavy metals, gathered from water samples at Buckingham Canal, Neelankarai, Chennai. Water samples were examined for heavy metal analysis, and the highest toxic heavy metals, Zn, Pb, Mn, Cu, and Cr, were recorded.

Characterization of Crude Oil Degrading Marine Bacterium .

The spillage of petroleum hydrocarbons, one of the most versatile energy resources, leads to disastrous environmental pollution. The present study aims to degrade oil using enzymes from bacterial strains. A total of 39 bacteria were isolated from six different soil samples collected from Ullal Beach, Mangalore, Karnataka, located at 12°52'N latitude and 74°49'E longitude, India.

Investigating the toxicity of malachite green and copper sulfate in brine shrimp: and computational study.

Colour is crucial for enhancing the appetizing value and consumer acceptance of food products. The commonly used food colourants and food preservatives such as Malachite Green (MG) and Copper Sulfate (CS) can cause severe health problems. This study investigates the toxicity of these food-grade colourants through acute exposure using cytotoxicity using the brine shrimp model including 3D surface analysis (3DSA) and studies Brine shrimp were treated with various concentrations of MG and CS.

Resveratrol: A Natural Compound Targeting the PI3K/Akt/mTOR Pathway in Neurological Diseases.

Neurological diseases (NDs), including neurodegenerative disorders and acute injuries, are a significant global health concern. The PI3K/Akt/mTOR pathway, a crucial signaling cascade, is responsible for the survival of cells, proliferation, and metabolism. Dysregulation of this pathway has been linked to neurological conditions, indicating its potential as a vital target for therapeutic approaches.

Hybrid prediction model with improved score level fusion for heart disease diagnosis.

Heart disease diagnosis is a challenging task, which provides an automated forecast of the patient's heart illness to make future treatment simpler. This has led to extensive interest in heart disease diagnostics in the medical sector. However, as there are various risks, the prediction must be more appropriate to avoid death.

Cellular stress response and neuroprotection of flavonoids in neurodegenerative diseases: Clinical insights into targeted therapy and molecular signaling pathways.

Neurodegenerative diseases (NDs) are caused by the gradual decline of neuronal structure and function, which presents significant challenges in treatment. Cellular stress responses significantly impact the pathophysiology of these disorders, often exacerbating neuronal damage. Plant-derived flavonoids have demonstrated potential as neuroprotective agents due to their potent anti-inflammatory, anti-apoptotic, and antioxidant properties.

Immune Modulation Strategies in Gene Therapy: Overcoming Immune Barriers and Enhancing Efficacy.

The immune system presents significant obstacles to gene therapy, which has limited its use in treating many illnesses. New approaches are needed to overcome these problems and improve the effectiveness of gene therapy. This study explores several techniques to immune regulation within gene therapy, a cutting-edge discipline that aims to optimise results by fine-tuning the immune response.

Effect of Graphite Nanoadditives on the Behavior of a Diesel Engine Fueled with Pyrolysis Fuel Recovered from Used Plastics.

Plastic waste accumulation is a significant threat to the environment and humans. Pyrolysis is a promising method for recycling plastic waste since all of the yields are useful, reducing the associated environmental risks of plastic waste. Energy recovery from used plastic waste can help restore ecosystems by utilizing waste as fuel while addressing the environmental problem of plastic disposal.

Bibliometric analysis of artificial intelligence in healthcare research: Trends and future directions.

Objective: The presence of artificial intelligence (AI) in healthcare is a powerful and game-changing force that is completely transforming the industry as a whole. Using sophisticated algorithms and data analytics, AI has unparalleled prospects for improving patient care, streamlining operational efficiency, and fostering innovation across the healthcare ecosystem. This study conducts a comprehensive bibliometric analysis of research on AI in healthcare, utilising the SCOPUS database as the primary data source.

PPG2RespNet: a deep learning model for respirational signal synthesis and monitoring from photoplethysmography (PPG) signal.

Breathing conditions affect a wide range of people, including those with respiratory issues like asthma and sleep apnea. Smartwatches with photoplethysmogram (PPG) sensors can monitor breathing. However, current methods have limitations due to manual parameter tuning and pre-defined features.

Efficacy of a Four-Week Diagonal Pattern Exercise Program on Trunk and Lower Limb Function in Patients With Stroke-Induced Hemiplegia.

Objective The intended effect of this investigation is to quantify the efficacy of a four-week program of diagonal pattern exercises in managing trunk impairments and improving gait difficulties in hemiplegic stroke subjects. The study aims to measure changes in trunk stability and gait parameters post-intervention, providing insights into the potential therapeutic benefits of these exercises for stroke rehabilitation. Methodology This experimentation approach encompassing before and the follow-up test evaluations was implemented in this investigation.

Enhancing Dynamic Balance and Postural Stability in Stroke Patients: The Impact of Immersive Virtual Reality Training.

Introduction Stroke is a major neurological event resulting from reduced or blocked blood flow to the brain, leading to significant morbidity. Immediate medical attention is essential to minimize brain damage and improve outcomes since it leads to many clinical deficits like locomotor impairment, instability in postural control, tonic alterations of the affected musculature, and an array of neurological dysfunctions if left unnoticed. Immersive virtual reality (VR) has emerged as a novel therapeutic tool in stroke rehabilitation, offering engaging and realistic environments for therapy.

Alkaloid-based modulators of the PI3K/Akt/mTOR pathway for cancer therapy: Understandings from pharmacological point of view.

This review aims to summarize the role of alkaloids as potential modulators of the PI3K/Akt/mTOR (PAMT) pathway in cancer therapy. The PAMT pathway plays a critical role in cell growth, survival, and metabolism, and its dysregulation contributes to cancer hallmarks. In healthy cells, this pathway is tightly controlled.

Novel Hybrid Quantum Architecture-Based Lung Cancer Detection Using Chest Radiograph and Computerized Tomography Images.

Lung cancer, the second most common type of cancer worldwide, presents significant health challenges. Detecting this disease early is essential for improving patient outcomes and simplifying treatment. In this study, we propose a hybrid framework that combines deep learning (DL) with quantum computing to enhance the accuracy of lung cancer detection using chest radiographs (CXR) and computerized tomography (CT) images.

Preparation of self-preserving personal care cosmetic products using multifunctional ingredients and other cosmetic ingredients.

The development of self-preserving personal care cosmetics represents a significant advancement in the cosmetics industry, offering safer and more natural alternatives to consumers. This study focused on the preparation of such formulations using multifunctional ingredients along with other cosmetic components. Five unique multifunctional ingredients (MFIs) were identified based on their antimicrobial properties: sodium coco PG-dimonium chloride phosphate, ricinoleic acid, palmitoleic acid, raspberry ketone, and sorbitan caprylate.

Deep learning ensemble approach with explainable AI for lung and colon cancer classification using advanced hyperparameter tuning.

Lung and colon cancers are leading contributors to cancer-related fatalities globally, distinguished by unique histopathological traits discernible through medical imaging. Effective classification of these cancers is critical for accurate diagnosis and treatment. This study addresses critical challenges in the diagnostic imaging of lung and colon cancers, which are among the leading causes of cancer-related deaths worldwide.

Therapeutic Potential of Resveratrol and Lignans in the Management of Tuberculosis.

This study aims to investigate the therapeutic potential of herbal remedies, specifically resveratrol and lignans, as alternative treatments for tuberculosis (TB), given the challenges posed by drug-resistant strains and adverse effects of conventional therapies. A comprehensive review of the literature was conducted to analyze the mechanisms of action, safety profiles, and efficacy of resveratrol and lignans in the context of TB management. This review focused on the bactericidal and bacteriostatic effects of these compounds, examining their interaction with Mycobacterium tuberculosis within macrophages.

Polyphenols as Therapeutics in Respiratory Diseases: Moving from Preclinical Evidence to Potential Clinical Applications.

Respiratory diseases are the most common and severe health complication and a leading cause of death worldwide. Despite breakthroughs in diagnosis and treatment, few safe and effective therapeutics have been reported. Phytochemicals are gaining popularity due to their beneficial effects and low toxicity.