Computational formulation study of insulin on biodegradable polymers.

Insulin administered orally has a limited therapeutic profile due to factors such as digestion enzymes, pH, temperature, and acidic conditions in the gastrointestinal tract. Type 1 diabetes patients are typically restricted to use intradermal insulin injections to manage their blood sugar levels as oral administration is not available. Research has shown that polymers could enhance the oral bioavailability of therapeutic biologicals, but traditional methods for developing suitable polymers are time-consuming and resource-intensive.