β-catenin attenuation by a mefloquine-loaded core-shell nano emulsion strategy to suppress liver cancer cells.

Liver cancer, with its robust metastatic propensity, imposes a substantial global health burden of around 800 000 new cases annually. Mutations in the Wnt/β-catenin pathway genes are common in liver cancer, driving over 80% of cases. Targeting this pathway could potentially lead to better treatments.

An efficient and simple approach for synthesizing indazole compounds using palladium-catalyzed Suzuki-Miyaura cross-coupling.

A series of indazole derivatives (6a-6i and 7a-7i) has been synthesized using Suzuki Miyaura cross-coupling with a palladium catalyst from readily available starting materials. An efficient and reliable methodology was employed for the synthesis, and the compounds were thoroughly characterized using H NMR, C NMR, FT-IR, and HRMS analysis to confirm their structural integrity and purity. Density function theory (DFT) computation identified four compounds (6g, 6h, 7g, and 7h) with significant energy band gaps.

Fabrication of a free-standing TiCT -PTh counter electrode interfacial polymerization for dye-sensitized solar cells.

The current work involves the fabrication of a MXene-Polythiophene (TiCT -PTh) composite interfacial polymerization, alongside its deployment as a counter electrode (CE) or photocathode in dye-sensitized solar cells (DSSCs). The structural properties of the synthesized materials were investigated through a comprehensive array of techniques, including X-ray diffraction (XRD), fourier-transform infrared (FT-IR) spectroscopy, high resolution scanning electron microscopy (HRSEM), energy-dispersive X-ray analysis (EDAX), and X-ray photoelectron spectroscopy (XPS). The electrochemical performance, assessed cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), revealed that the TiCT -PTh CE exhibits superior electro-catalytic activity, and reduction in charge transfer resistance compared to other individual CEs.

Modulating acid sites in Y zeolite for valorisation of furfural to get γ-valerolactone.

Furfural is a biomass-derived platform molecule that can be converted into a variety of useful products. Catalysts having appropriate balance between Lewis and Brønsted acid sites are suitable for valorisation of furfural. Lewis acidic metal ion incorporated zeolites were studied for this purpose.

Synergistic impact of nanoplastics and nanopesticides on and toxicity analysis.

Polystyrene nanoplastics (PSNPs) when exposed to nanopermethrin (NPER) exacerbate toxicity on . In the environment, NPs act as a vector for other pollutants mainly heavy metals and pesticides. Nanopesticides are efficient compared to their bulk form.

The Tishchenko reaction mediated by organo-f-complexes: the myths and obstacles.

For over a century, the Tishchenko reaction has been a valuable technique for synthesizing esters from aldehydes, serving a variety of applications in different domains. Beyond the remarkable advances in organoactinide and organolanthanide chemistry over the past two decades, there has been a significant increase in the research of the electrophilic d0/fn chemistry of organoactinide and organolanthanide compounds due to the captivating interplay between their structure and reactivity, and their exceptional performance in various homogeneous catalytic processes. The remarkable influence of ligand design, both in terms of steric hindrance and electronic properties, on the catalytic activity of organo-f-element complexes in organic transformations is well-established.

Sustainable carbon dots from : enhanced colorimetric sensing of Fe ions and biological applications in live cell imaging.

This study presents the synthesis of advanced nanomaterials derived from the hedge-grown herbal plant, , and explores their environmental and biological applications. Using a one-step hydrothermal synthesis method, carbon dots derived from (BHCD) were fabricated and thoroughly characterized through XRD, TEM, FTIR, CHNS, UV-visible, and PL spectroscopy analyses. Under UV illumination, these plant-based carbon dots demonstrated exceptional water solubility, notable photo stability, and a high quantum yield of 40.

Bioactive O^N^O^ Schiff base appended homoleptic titanium(iv) complexes: DFT, BSA/CT-DNA interactions, molecular docking and antitumor activity against HeLa and A549 cell lines.

Five new homoleptic derivatives of titanium(iv) have been developed and characterized by physicochemical techniques. Metal complexes, TiHL [(CHNO)Ti], TiHL [(CHFNO)Ti], TiHL [(CHClNO)Ti], TiHL [(CHBrNO)Ti] and TiHL [(CHNO)Ti], were obtained by treating Ti(OPr) with appropriate ONO ligands (HL-HL) in anhydrous THF as solvent. The electronic structures and properties of titanium(iv) complexes (TiHL-TiHL) and ligands (HL-HL) were examined by DFT studies.

Synthesis molecular docking and DFT studies on novel indazole derivatives.

The amide bond is an important functional group used in various fields of chemistry, including organic synthesis, drug discovery, polymers, and biology. Although normal amides are planar, and the amide has an N-C(O) bond, herein, the 26 indazole derivatives were reported amide cross-coupling (8a-8z). Using IR, H NMR, C NMR, and mass spectrometry, all of the produced compounds were analysed.

Correction: Photocatalytic degradation of drugs and dyes using a machine learning approach.

[This corrects the article DOI: 10.1039/D4RA00711E.].

Synthesis and study of antibiofilm and antivirulence properties of flavonol analogues generated by palladium catalyzed ligand free Suzuki-Miyaura coupling against PAO1.

The Suzuki-Miyaura coupling is one of the ubiquitous method for the carbon-carbon bond-forming reactions in organic chemistry. Its popularity is due to its ability to undergo extensive coupling reactions to generate a broad range of biaryl motifs in a straightforward manner displaying a high level of functional group tolerance. A convenient and efficient synthetic route to arylate different substituted flavonols through the Suzuki-Miyaura cross-coupling reaction has been explained in this study.

Photocatalytic degradation of drugs and dyes using a maching learning approach.

The waste management industry uses an increasing number of mathematical prediction models to accurately forecast the behavior of organic pollutants during catalytic degradation. With the increasing quantity of waste generated, these models are critical for reinforcing the efficiency of wastewater treatment strategies. The application of machine-learning techniques in recent years has notably improved predictive models for waste management, which are essential for mitigating the impact of toxic commercial waste on global water supply.

Phenothiazine appended thiophene derivative: a trilateral approach to copper ion detection in living cells and aqueous samples.

This research paper unveils a fluorescent probe (PTZ-SCN) engineered for the specific detection of Cu, featuring a 10-ethyl-10-phenothiazine-3-carbaldehyde and 2-(thiophen-2-yl) acetonitrile moiety. The fluorescence sensing behavior of PTZ-SCN towards various metal cations was scrutinized in CHCN : HEPES (9 : 1) buffer aqueous solution. The UV absorbance of PTZ-SCN displayed a distinct red shift in the presence of Cu cations, whereas other metal cations did not cause any interference.

Investigation on the growth aspects and properties of rubidium hydrogen succinate hydrate single crystal for NLO applications.

A novel semiorganic nonlinear optical single crystal of rubidium hydrogen succinate hydrate (RbHSH) was grown at room temperature using the slow evaporation solution growth technique (SEST) with water as a solvent for nonlinear optical applications. The grown crystal is a triclinic system with a centrosymmetric space group of 1̄ and the compound is stabilized by intramolecular O-H-O and C-H-O bonding. FTIR spectral studies were used to determine the various functional groups present in the material.

A phenothiazine-functionalized pyridine-based AIEE-active molecule: a versatile molecular probe for highly sensitive detection of hypochlorite and picric acid.

In this study, we designed and synthesized a novel compound (PTH-AB-PY) based on phenothiazine and pyridine moieties with aggregation-induced emission enhancement (AIEE) properties. The compound has shown exceptional selectivity and sensitivity towards ClO ions with an impressive detection limit of 6.86 × 10 M.

Journey of micronanoplastics with blood components.

The entry of micro- and nanoplastics (MNPs) into the human body is inevitable. They enter blood circulation through ingestion, inhalation, and dermal contact by crossing the gut-lung-skin barrier (the epithelium of the digestive tract, the respiratory tract, and the cutaneous layer). There are many reports on their toxicities to organs and tissues.

Role of the solvent polarity on the optical and electronic characteristics of 1-iodoadamantane.

The natural absorbance caused by the chromophore and chemical behavior of 1-iodoadamantane is highly influenced by the polarity of different solvent environments. This gives rise to the solvatochromatic shifts in the optical absorption and electronic structure and the experimentally measured UV-vis absorption spectra show significant solvatochromic shifts with respect to the solvent polarity. The absorption shift for both σ to σ*and n to σ* electronic transitions are more dominant in polar solvents than in nonpolar solvents.

A novel stilbazolium derivative crystals of 4-[2-(4-dimethyl amino-phenyl)-vinyl]-1-methyl-pyridinium bromide (DMSB) single crystal: exploration of the growth, molecular structure, linear optical, and third order nonlinear properties.

A novel third-order stilbazolium derivative single crystal, 4-[2-(4-dimethyl amino-phenyl)-vinyl]-1-methyl-pyridinium bromide (DMSB), was fruitfully harvested using methanol as a medium, through a slow evaporation technique. The solubility of the prepared DMSB powder was experimentally tested at different temperatures (30 °C to 50 °C) with a methanol solvent. Single crystal X-ray diffraction analysis (SCXRD) implied that the DMSB crystal crystallized in a centrosymmetric fashion (space group 2/) with the monoclinic crystal system.

Ecotoxicological significance of bio-corona formation on micro/nanoplastics in aquatic organisms.

The unsustainable manufacturing, utilization and inadequate handling of plastics have led to a surge in global plastic pollution. In recent times, there has been increasing concern about the plausible hazards associated with exposure to micro/nanoplastics (M/NPs). As aquatic systems are considered to be the likely sink for M/NPs, it is crucial to comprehend their environmental behavior.

Different routes for the construction of biologically active diversely functionalized bicyclo[3.3.1]nonanes: an exploration of new perspectives for anticancer chemotherapeutics.

Cancer is the second most high-morbidity disease throughout the world. From ancient days, natural products have been known to possess several biological activities, and research on natural products is one of the most enticing areas where scientists are engrossed in the extraction of valuable compounds from various plants to isolate many life-saving medicines, along with their other applications. It has been noticed that the bicyclo[3.

Type-II ternary BiWO/rGO/SnFeO heterojunction nanocomposites and their photocatalytic efficiency towards 4-nitrophenol reduction.

In this study, tin ferrite (SnFeO-spinel) and bismuth tungstate (BiWO) encapsulated on reduced graphene oxide (rGO) were synthesised using the hydrothermal method. This heterostructure nanocomposite was characterised using Fourier transform infrared spectroscopy (FT-IR), Ultraviolet-visible spectroscopy (UV-Vis), powder X-ray diffraction (XRD), Scanning electron microscopy (SEM), FT-Raman Spectroscopy (FT-Raman) and X-ray photoelectron spectroscopy (XPS) methods. The powder XRD results showed an increase in lattice parameters and a decrease in size when SnFeO and BiWO were encapsulated on rGO.

Anti-proliferative activity of nitroquinolone fused acylhydrazones as non-small cell human lung cancer agents.

A new series of 8-nitroquinolone-based aromatic heterocyclic acyl hydrazones have been synthesised and characterised through various spectroscopic techniques. They were theoretically examined for molecular docking with various proteins related to the apoptosis of the non-small cell lung cancer cell line A549. The results indicate that the possible modes of interaction of all the synthesised compounds are compatible for use as anti-proliferative drugs.

Computational formulation study of insulin on biodegradable polymers.

Insulin administered orally has a limited therapeutic profile due to factors such as digestion enzymes, pH, temperature, and acidic conditions in the gastrointestinal tract. Type 1 diabetes patients are typically restricted to use intradermal insulin injections to manage their blood sugar levels as oral administration is not available. Research has shown that polymers could enhance the oral bioavailability of therapeutic biologicals, but traditional methods for developing suitable polymers are time-consuming and resource-intensive.

Synthesis, characterization, photophysical and electrochemical properties, and biomolecular interaction of 2,2'-biquinoline based phototoxic Ru(II)/Ir(II) complexes.

The phototoxic nature of drugs has been seen to convey immense importance in photo activated chemotherapy (PACT) for the selective treatment of disease. Rationally, in order to eradicate the vehemence of cancer in a living body, the design of phototoxic molecules has been of growing interest in research to establish a selective strategy for cancer therapy. Therefore, the present work portrays the synthesis of a phototoxic anticancer agent by incorporating ruthenium(II) and iridium(III) metals into a biologically active 2,2'-biquinoline moiety, BQ.

An ultrasensitive "mix-and-detect" kind of fluorescent biosensor for malaoxon detection using the AChE-ATCh-Ag-GO system.

Malaoxon, a highly toxic metabolite of malathion, can lead to severe harm or death if ingested. This study introduces a rapid and innovative fluorescent biosensor that relies on acetylcholinesterase (AChE) inhibition for detecting malaoxon using Ag-GO nanohybrid. The synthesized nanomaterials (GO, Ag-GO) were evaluated with multiple characterization methods to confirm their elemental composition, morphology, and crystalline structure.