Using KMeans Clustering to Evaluate and Alert for Deviations of Linac Photon Beam Parameters.

Objective: To analyse the daily measured Dosimetric Quality Assurance (QA) parameters of linear accelerator (linac) using Unsupervised Machine Learning (ML) Algorithm thereby evaluating the current machine status and to highlight the probable cause of the 'out-of-range' measured parameter.

Methods: Five Parameters measured using PTW QuickCheckwebline device in a linac is subjected to KMeans clustering technique.  The measured parameters comprise of Central Axis Dose (CAX), Beam Flatness, SymmetryLR, SymmetryGT and Beam Quality (BQF).

Unveiling the Modification of Esterase-like Activity of Serum Albumin by Nanoplastics and Their Cocontaminants.

Nanoplastics and other cocontaminants have raised concerns due to their widespread presence in the environment and their potential to enter the food chain. The harmful effects of these particles depend on various factors, such as nanoparticle size, shape, surface charge, and the nature of the cocontaminants involved. On entering the human body, human serum albumin (HSA) molecules bind and transport these particles in the blood system.

Pivotal avenue for hybrid electron transport layer-based perovskite solar cells with improved efficiency.

This study conducted a simulative analysis of different hybrid perovskite solar cells with various hybrid electron transport layers (ETL) and hole transport layers (HTL). The electron transport layer boosts durability, lowers production costs, increases stability, improves light absorption, and increases efficiency. Hybrid ETLs are taken into consideration to improve the device's performance.

Quantum chemical, spectroscopic and molecular docking studies on methyl 2-chloro-6-methyl pyridine-4-carboxylate: A potential inhibitor for irritable bowel syndrome.

The methyl 2-chloro-6-methyl pyridine-4-carboxylate (MCMP) was studied using quantum chemical density functional theory (DFT) approach. The DFT/B3LYP method with cc-pVTZ basis set was employed to obtain the optimized stable structure and vibrational frequencies. The potential energy distribution (PED) calculations were used to assign the vibrational bands.

Transformation of used aluminium foil food container into AlOOH nanoflakes with high catalytic activity in anionic azo dye reduction.

Synthesis of aluminium-based nanomaterials from aluminium-waste has received huge attention in current scientific research. Herein, an attempt was made to convert aluminium foil food container into aluminium oxyhydroxide (AlOOH) nanoparticles by a precipitation method. X-ray diffraction (XRD), spectroscopic and electron microscopic studies were employed to characterize impure AlOOH (containing sodium chloride, NaCl) and pure AlOOH samples.

Waste toner-derived porous iron oxide pigments with enhanced catalytic degradation property.

'Wealth from Waste' is an emerging concept, since it leads an effective waste treatment and waste recyclability. On the other hand, cost effective production iron oxide (IO) nanomaterials is still needed to develop, owing to their wide applications. Herein, we proposed a simple direct calcination method to prepare porous IO (FeO and FeO) nanomaterials from waste toner powder.

Quantum chemical, spectroscopic and molecular docking investigations of potential pulmonary fibrosis drug methyl 2-chloro 4-iodonicotinate.

In this work, the methyl 2-chloro 4-iodonicotinate (MCIN) was investigated to study the structural, spectroscopic and electronic properties using density functional theory (DFT) quantum chemical calculations. The most stable structure of MCIN was optimized by DFT/B3LYP method with a LanLD2Z basis set. The optimized parameters and vibrational wavenumbers were determined.

Retraction: Anti-cancer activity of hierarchical ZSM-5 zeolites synthesized from rice-based waste materials.

[This retracts the article DOI: 10.1039/C7RA11763A.].

A Combination of Action Research and Reflective Journal Writing in an English as a Foreign Language Class: Learners' Psychological Point of Views and Their Grammar Use in Writing.

Action research (AR) and reflective thinking (RT) can enhance learning since both processes provide students with the opportunities to step back and think about how they actually solve problems. While there is a robust academic inquiry on reflection practices and AR in the educational setting, investigating learners' reflections through AR practices can shed more light on related research. This study implemented reflective journal writing through AR and aimed to investigate (1) the participants' views about reflective journal writing, (2) the effects of journal writing on RT development, and (3) the learners' grammar use in writing.

The molecular basis of gender disparities in smoking lung cancer patients.

Aims: Gender disparities exist in smoking-related lung cancer epidemiology, but the molecular basis has not been explored so far. We aimed at identifying genes with gender-bias expression pattern in smoking lung cancer patients for understanding the molecular basis of gender bias in smokers using meta-analysis of microarray gene expression data.

Materials And Methods: Transcriptome of around 1100 samples from 13 studies were used in the meta-analysis to identify 'Lung Cancer genes specific to Female-Smokers' (LCFS) and 'Lung Cancer genes specific to Male-Smokers' (LCMS).

Bioactivity of melianone against and in silico prediction of a membrane protein target.

Melianone, the protolimonoid (24, 25-epoxyflindissone), was isolated from the medicinal tree species, (L.) JACQ (Meliaceae). The compound isolated from petroleum ether leaf extracts (5.

Biodecolorization and Biodegradation of Azo Dye Reactive Orange-16 by Marine sp.

Background: Azo dyes are xenobiotic compounds that have bioaccumulated in the environment due to escalated industrial development. These are hazardous in nature, possessing carcinogenic and mutagenic effects on human beings.

Objectives: The perspective of the present study was to isolate and to determine azo dye (Reactive Orange-16) degrading potential of marine actinobacteria isolated from sediment samples of Port Blair, India.

Systematic comparison of the protein-protein interaction databases from a user's perspective.

In absence of periodic systematic comparisons, biologists/bioinformaticians may be forced to make a subjective selection among the many protein-protein interaction (PPI) databases and tools. We conducted a comprehensive compilation and comparison of such resources. We compiled 375 PPI resources, short-listed 125 important ones (both lists are available at startbioinfo.

Radiobiological and dosimetric impact of RayStation pencil beam and Monte Carlo algorithms on intensity-modulated proton therapy breast cancer plans.

Purpose: RayStation treatment planning system employs pencil beam (PB) and Monte Carlo (MC) algorithms for proton dose calculations. The purpose of this study is to evaluate the radiobiological and dosimetric impact of RayStation PB and MC algorithms on the intensity-modulated proton therapy (IMPT) breast plans.

Methods: The current study included ten breast cancer patients, and each patient was treated with 1-2 proton beams to the whole breast/chestwall (CW) and regional lymph nodes in 28 fractions for a total dose of 50.

Viral vector: potential therapeutic for glioblastoma multiforme.

Glioblastoma multiforme is a highly malignant primary brain tumour found in adults and is highlighted as the most devastating among all the other grades of glioma. Well-established standard treatment methods, such as chemotherapy, radiation and surgery, have resulted in modest improvement in the survival of patients. Hence, the arduous search for novel treatments backed by advancements in molecular biology still persists.

Measurements of in-air spot size of pencil proton beam for various air gaps in conjunction with a range shifter on a ProteusPLUS PBS dedicated machine and comparison to the proton dose calculation algorithms.

The purpose of this study is to (i) investigate the impact of various air gaps in conjunction with a range shifter of 7.5 cm water-equivalent-thickness (WET) on in-air spot size of a pencil proton beam at the isocenter and off-axis points, and (ii) compare the treatment planning system (TPS) calculated spot sizes against the measured spot sizes. A scintillation detector has been utilized to measure the in-air spot sizes at the isocenter.

Aug-MIA-QSAR based strategy in bioactivity prediction of a series of flavonoid derivatives as HIV-1 inhibitors.

Multivariate image analysis-quantitative structure-activity relationship (MIA-QSAR) is a simple and quite accessible QSAR method for predicting biological activities of compounds based on two-dimensional image analysis. Aug-MIA-QSAR is a modified version of multivariate image analysis, where the atoms in 2D chemical structures were augmented (labelled by assigning specific colours). This study focuses on efficiently constructing such prediction models using a dataset of flavonoid derivatives possessing human immunodeficiency virus - 1 inhibition.

Electrochemical Studies on Fruit Shell Bio-Waste Derived Nanoporous Activated Carbons for Supercapacitor Applications.

Supercapacitors are perfect energy storage devices; they can be charged almost instantly and release energy over a long period. Another advantage of using supercapacitors is their multipletimes chargeable behavior with minimum degradation in performance. Herein, we report the nanoporous activated carbon based modified electrodes prepared by using phosphoric acid (PA) activation method at different temperatures (600, 700, 800, and 900 °C) using bio-waste precursor, () fruit shell.

Allura red rapidly induces amyloid-like fibril formation in hen egg white lysozyme at physiological pH.

Allura red (AR) is an artificial azo dye mostly used in food industries and has potential health risks. We examined the role of AR in amyloidogenesis using hen egg white lysozyme (HEWL) at pH 7.0.

Epidemiologic analysis of breast cancer incidence, prevalence, and mortality in India: Protocol for a systematic review and meta-analyses.

Background: Breast Cancer (BC) is the leading cause of deaths in Indian women. Emerging reports reveal alarming evidence of increasing incidence and mortality of BC among young Indian women in addition to the late presentation and poor prognosis. Despite the significant incidence, there is a lack of reliable data resources and comprehensive epidemiologic studies relating to BC.

Bandgap Engineering in Doped ZnO Nanostructures for Dye Sensitized Solar Cell Applications.

Pure ZnO and dZnO (doped ZnO) systems of type ZnMO (M = Co, Cu, Fe and Mn) synthesised by co-precipitation method were evaluated for DSSC studies. Tween-80, a non-ionic surfactant which was used during preparation process also acted as binder for coating the nanoparticles on the FTO glass plate. In order to reduce the band gap, transition metal dopants have been incorporated into ZnO so that it changes the photo electrochemical properties.

Green Synthesis of Co₃O₄ Nanorods for Highly Efficient Catalytic, Photocatalytic, and Antibacterial Activities.

Cobalt oxide nanorods were successfully synthesized by a hot plate combustion method using the plant extract of . The plant extract as an alternative to toxic chemicals can be used generally as reducing and capping agents. The obtained nanorods were characterized by XRD, FT-IR, Raman, TEM, SAED, EDX, DRS, PL and VSM techniques for the structural, morphological, optical and magnetic properties.

MIA-QSAR based model for bioactivity prediction of flavonoid derivatives as acetylcholinesterase inhibitors.

Alzheimer's disease is a common form of dementia, which considered to be a major health concern. Multivariate Image Analysis - Quantitative Structure-Activity Relationship (MIA-QSAR) is a simple and quite accessible QSAR method for predicting biological activities of unstudied compounds based on 2D image analysis. This study focuses on constructing an efficient QSAR model using a dataset of 52 flavonoid derivatives (substituted with amino-alkyl, alkoxy, alkyl-amines, and piperidine groups) as active compounds against acetylcholinesterase inhibitors (AChE).

In-vitro anti-cancer activity of organic template-free hierarchical M (Cu, Ni)-modified ZSM-5 zeolites synthesized using silica source waste material.

The present paper is focused on a simple and economical route to synthesize the organic template-free hierarchical pure and M (Cu, Ni)-modified ZSM-5 zeolites (1%, 3% and 5%) using hydrothermal treatment in the presence of silica rich rice husk ash and its application studies through the evaluation of their anti-cancer activity on A459 human lung epithelial cancer cell lines. The physical properties of the samples were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, high resolution scanning electron microscopy, high resolution transmission electron microscopy, N adsorption/desorption techniques and thermogravimetric analysis respectively. These metals modified hierarchical ZSM-5 zeolites showed considerable in-vitro anticancer efficiency towards human lung cancer (A549) cell lines through (3-(4, 5-dimethyl thiazolyl)-2, 5-diphenyl tetrazolium bromide) MTT assay.