620 results match your criteria: "Vassar College.[Affiliation]"

When we use language to communicate, we must choose what to say, what not to say, and how to say it. That is, we must decide how to the message. These linguistic choices matter: Framing a discussion one way or another can influence how people think, feel, and act in many important domains, including politics, health, business, journalism, law, and even conversations with loved ones.

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Carbohydrate Deacetylase Unique to Gut Microbe Bacteroides Reveals Atypical Structure.

Biochemistry

January 2025

Department of Chemistry, Vassar College, 124 Raymond Ave, Poughkeepsie, New York 12604, United States.

Article Synopsis
  • Many gut microbiome species in industrialized populations offer both benefits, like reducing intestinal inflammation, and risks, such as links to autoimmune disorders like IBD.
  • Recent research focused on bacterial cell surface carbohydrates, specifically capsular polysaccharides (CPS), which play a role in these interactions but still raises several unknowns.
  • The study highlights the structural and functional characteristics of a unique polysaccharide deacetylase enzyme from this gut microbe, providing insights into CPS biosynthesis that may impact its medical relevance.
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  • Translation initiation significantly influences gene expression in eukaryotes, with eukaryotic initiation factor 3 (eIF3) playing a key role in recruiting ribosomes.
  • This study examined how eIF3's binding to specific 5'-untranslated regions (5'-UTRs) of mRNAs leads to varying protein outputs, finding that it binds to a specific motif, AMAYAA, in some 5'-UTRs.
  • The study demonstrates that mRNAs bound by eIF3 have higher ribosome density and are preferentially translated during stress, highlighting eIF3's role as a novel translational enhancer.
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  • Most autism research targets those with formal diagnoses, neglecting the experiences of individuals who self-identify as autistic, especially in the queer and transgender community.
  • A study involving 65 queer and transgender adults revealed that both diagnosed and self-identified individuals encounter obstacles in obtaining an autism diagnosis and often face invalidation related to their identity.
  • The study suggests that researchers and advocates should include self-identified autistic individuals in autism research and services to better address their needs and experiences.
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For three decades, researchers have assessed children's genetic essentialism through an "Adoption Task," probing their beliefs about whether adopted babies grow up to resemble their birthparents or adoptive parents. The present study investigates these beliefs among children who were themselves adopted or donor-conceived (i.e.

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Supersonic turbulence occurs in many environments, particularly in astrophysics. In the crucial case of isothermal turbulence, the probability density function (PDF) of the logarithmic density, , is well measured, but a theoretical understanding of the processes leading to this distribution remains elusive. We investigate these processes using Lagrangian tracer particles to track and [Formula: see text] in direct numerical simulations, and we show that their evolution can be modeled as a stochastic differential process with time-correlated noise.

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Sex-Specific Effects of Anxiety on Cognition and Activity-Dependent Neural Networks: Insights From (Female) Mice and (Wo)men.

Biol Psychiatry

September 2024

Division of Systems Neuroscience, Research Foundation for Mental Hygiene, Inc. (RFMH)/New York State Psychiatric Institute (NYSPI), New York, New York; Department of Psychiatry, Columbia University Irving Medical Center (CUIMC), New York, New York. Electronic address:

Background: Neuropsychiatric symptoms, such as depression and anxiety, are observed in 90% of patients with Alzheimer's disease (AD), two-thirds of whom are women. Neuropsychiatric symptoms usually manifest long before AD onset creating a therapeutic opportunity. Here, we examined the impact of anxiety on AD progression and the underlying brainwide neuronal mechanisms.

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The synthesis and spectroscopic characterization of three complexes containing a substituted 2-(2-pyridyl)benzothiazole (PyBTh) group in the ligand frame are reported along with the comparative biological activity. The ligands have been substituted at the 6-position with either a methoxy (Py(OMe)BTh) or a methyl group (Py(Me)BTh). Reaction of Py(OMe)BTh with either CuCl or Cu(NO)·2.

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Novel sensing applications benefit from multifunctional nanomaterials responsive to various external stimuli such as mechanics, electricity, light, humidity, or pollution. While few such materials occur naturally, the careful design of synergized nanomaterials unifies the cross-coupled properties which are weak or absent in single-phase materials. In this study, 2D MoS integrated with ultrathin dielectric oxide layers forms hetero-nanostructures with significant impacts on carrier transport.

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Modeling Hemodynamics in Three-Dimensional, Biomimetic, Branched, Microfluidic, Vascular Networks.

Microcirculation

November 2024

Bioengineering Program, DeMatteis School of Engineering and Applied Science, Hofstra University, Hempstead, New York, USA.

Objective: Neovascularization has been extensively studied because of its significant role in both physiological processes and diseases. The significance of vascular microfluidic platforms lies in its essential role in recreating an in vitro environment capable of supporting cellular and tissue systems through the process of neovascularization. Biomechanical properties in a tissue engineered system use fluid flow and transport properties to recapitulate physiological systems.

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Embodied Computational Evolution: A Model for Investigating Randomness and the Evolution of Morphological Complexity.

Integr Org Biol

August 2024

Interdisciplinary Robotics Research Laboratory, Vassar College, Poughkeepsie, NY 12604, USA.

For an integrated understanding of how evolutionary dynamics operate in parallel on multiple levels, computational models can enable investigations that would be otherwise infeasible or impossible. We present one modeling framework, (), and employ it to investigate how two types of randomness-genetic and developmental-drive the evolution of morphological complexity. With these two types of randomness implemented as germline mutation and transcription error, with rates varied in an [Formula: see text] factorial experimental design, we tested two related hypotheses: ( ) Randomness in the gene transcription process alters the direct impact of selection on populations; and ( ) Selection on locomotor performance targets morphological complexity.

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We describe the antioxidant capability of scavenging the superoxide radical of several tea and yerba mate samples using rotating ring-disk electrochemistry (RRDE). We directly measured superoxide concentrations and detected their decrease upon the addition of an antioxidant to the electrochemical cell. We studied two varieties of yerba mate, two varieties of black tea from Bangladesh, a sample of Pu-erh tea from China, and two components, caffeic acid and chlorogenic acid.

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An infralimbic cortex neuronal ensemble encoded during learning attenuates fear generalization expression.

bioRxiv

November 2024

Department of Psychological Science, Program in Neuroscience and Behavior, Vassar College, Poughkeepsie NY 12603 USA.

Article Synopsis
  • Generalization helps us apply past experiences to new situations, and the infralimbic (IL) area in the brain is important for this process, although how it works is still not fully understood.
  • In an experiment with mice, it was found that manipulating the IL's activity affected their defensive behaviors in response to ambiguous threats: silencing the IL increased generalized freezing, while stimulating it encouraged more vigilant behavior.
  • Additionally, researchers identified specific groups of neurons (ensembles) in the IL that were linked to these generalized responses, revealing that these neuronal ensembles help control the degree of generalization when facing uncertain dangers.
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  • The late Paleocene and early Eocene periods were marked by long-term global warming and short, abrupt warming events called hyperthermals, largely influenced by greenhouse gases but possibly affected by other factors like tectonics.
  • Researchers analyzed data from planktic foraminifera to reconstruct sea surface temperatures and CO levels, focusing on key events such as the Paleocene-Eocene Thermal Maximum (PETM) and Eocene Thermal Maximum 2 (ETM-2).
  • Findings indicate a strong connection between CO and temperature, with different carbon sources contributing to the CO increases during these periods, and the emissions from these events are comparable to future projections, highlighting their relevance to current climate change discussions.
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Uranium is naturally occurring in groundwater used for drinking; however, health risks from naturally occurring concentrations are uncertain. Uranium can cause both radiological and chemical toxicity following ingestion. Bladder and kidneys receive a dose when uranium is excreted into the urine.

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  • Nearly all oviparous vertebrates lay eggs in either aquatic or terrestrial environments, each presenting unique challenges and opportunities for embryo development.
  • Research on 13 species of Central and South American treefrogs shows that flexible egg-laying behaviors and the ability for eggs to develop in both environments support the transition from aquatic to terrestrial reproduction.
  • Findings indicate species that reproduce exclusively on land tend to have larger eggs, and behavioral adaptations in egg-laying are likely the first steps toward evolving terrestrial reproduction, rather than changes in egg size.
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Dracunculiasis, also known as Guinea worm disease, is targeted to become the second human disease and first parasitic infection to be eradicated. The global Guinea Worm Eradication Program (GWEP), through community-based interventions, reduced the burden of disease from an estimated 3.5 million cases per year in 1986 to only 13 human cases in 2022.

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Board, card or video games have been played by virtually every individual in the world. Games are popular because they are intuitive and fun. These distinctive qualities of games also make them ideal for studying the mind.

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Background: Ethiopia has one of the highest maternal mortality ratios in Africa. Few have examined the quality of labour and delivery (L&D) care in the country. This study evaluated the quality of routine L&D care and identified patient-level and hospital-level factors associated with the quality of care in a subset of government hospitals.

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Orb-weaver spiders produce upwards of seven different types of silk, each with unique material properties. We focus on the adhesive within orb-weaving spider webs, aggregate glue silk. These droplets are composed of three main components: water, glycoproteins, and a wide range of low molecular mass compounds (LMMCs).

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The active time model of concurrent choice.

PLoS One

May 2024

Department of Psychological Science, Vassar College, Poughkeepsie, NY, United States of America.

The following paper describes a steady-state model of concurrent choice, termed the active time model (ATM). ATM is derived from maximization principles and is characterized by a semi-Markov process. The model proposes that the controlling stimulus in concurrent variable-interval (VI) VI schedules of reinforcement is the time interval since the most recent response, termed here "the active interresponse time" or simply "active time.

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Unlabelled: Host-associated microbial communities, like other ecological communities, may be impacted by the colonization order of taxa through priority effects. Developing embryos and their associated microbiomes are subject to stochasticity during colonization by bacteria. For amphibian embryos, often developing externally in bacteria-rich environments, this stochasticity may be particularly impactful.

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Background: Arterial stiffening may contribute to the pathogenesis of metabolic dysfunction-associated steatotic liver disease. We aimed to assess relations of vascular hemodynamic measures with measures of hepatic steatosis and fibrosis in the community.

Methods: Our sample was drawn from the Framingham Offspring, New Offspring Spouse, Third Generation, Omni-1, and Omni-2 cohorts (N=3875; mean age, 56 years; 54% women).

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Eukaryotic translation initiation factor (eIF) 3 is a multi-subunit protein complex that binds both ribosomes and messenger RNAs (mRNAs) to drive a diverse set of mechanistic steps during translation of an mRNA into the protein it encodes. And yet, a unifying framework explaining how eIF3 performs these numerous activities is lacking. Using single-molecule light scattering microscopy, we demonstrate that eIF3 is in dynamic exchange between the full complex, subcomplexes, and subunits.

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