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Article Synopsis
- Alternative splicing in the VEGF-A gene leads to two isoforms, VEGFa and VEGFb, which have different effects on blood vessel growth due to a 6-amino acid difference.
- VEGFb activates the VEGFR2 receptor but not the VEGFR1 receptor, while modifications to VEGFb can enhance its functionality, activating both pathways for better angiogenic response.
- The study reveals that changing specific amino acid residues in VEGFb can create a variant that activates both VEGFR1 and VEGFR2, promoting better recovery in a model of peripheral artery disease compared to VEGFa.