2,019 results match your criteria: "Vardhman Mahavir Medical College & Safdarjung Hospital[Affiliation]"

Article Synopsis
  • Hemangiomas are benign vascular tumors that primarily affect the skin and soft tissues, with anastomosing hemangioma (AH) being a specific subtype that mimics more serious conditions like angiosarcoma; there are fewer than 300 reported cases of renal hemangiomas.
  • A case study of a 28-year-old male revealed a left renal mass identified during tests for abdominal pain, with subsequent imaging and surgery confirming the diagnosis of AH through histopathological analysis and specific immunohistochemical markers.
  • Accurate diagnosis of AH is crucial to avoid unnecessary treatment and complications, highlighting the need for greater awareness and reporting in the medical community to enhance diagnostic accuracy and patient management.
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Purpose: This study evaluated the three year clinical outcomes and predictors of success for unicompartmental knee arthroplasty (UKA) in an Indian population.

Methods: Twenty patients with medial compartment osteoarthritis (≥ Ahlbäck grade 2) underwent UKA. American Knee Society Score (AKSS), Oxford Knee Score (OKS), and Visual Analogue Scale Score (VAS) were assessed at baseline, two weeks, six weeks, three months, and three years.

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Isolated plasmacytoma of the breast: A rare case report.

Int J Surg Case Rep

December 2024

Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India. Electronic address:

Introduction And Importance: Solitary plasmacytoma of the breast is an extremely rare manifestation of plasma cell neoplasms, predominantly seen in the bone marrow and commonly associated with multiple myeloma. When it occurs as an isolated lesion in the breast, it presents unique diagnostic and therapeutic challenges due to its rarity and clinical similarity to other breast conditions.

Case Presentation: We report a case of a 60-year-old female presenting with a gradually enlarging mass in her right breast over six months.

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Introduction: Caudal block is an effective regional anesthesia technique for perineal surgeries but is associated with various adverse effects. Recently, pudendal nerve block has emerged as a promising alternative for these procedures. This study assessed the effectiveness of a novel transperineal technique for ultrasound-guided pudendal nerve block and compares it with ultrasound-guided caudal block for perineal surgeries in pediatric patients.

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Background: Type 2 diabetes mellitus (T2DM) leads to cardiac autonomic neuropathy (CAN), affecting blood flow and heart rate regulation eventually causing chronic stable angina (CSA). Percutaneous coronary intervention (PCI) can correct autonomic dysfunctions and improve myocardial perfusion. This study aimed to assess CAN using heart rate variability (HRV) and cardiovascular reflex tests in T2DM patients with CSA before and after PCI.

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Introduction: Tuberculosis (TB) remains a global health concern with diverse clinical manifestations. Parotid tuberculosis, although rare, presents diagnostic challenges due to its atypical presentation. Cytological examination is pivotal in diagnosing parotid lesions.

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Accuracy of Financial Disclosures by Scientific Presenters/Authors at the ASNR 2024 annual meeting.

AJNR Am J Neuroradiol

November 2024

From the Department of Radiology and Biomedical Imaging (A.M., D.F., K.K., M.K., C.L., S.P.), Yale School of Medicine, New Haven, CT, USA; Vardhman Mahavir Medical College (V.S.), New Delhi, India; and Department of Radiology and Neurosurgery (D.G.), University of Maryland School of Medicine, Baltimore, MD, USA.

Physician-industry financial relationships can drive research and innovation, improving patient care and outcomes, but potentially raise ethical concerns if not disclosed appropriately. This study shows high rates of non-disclosures by authors/presenters at the ASNR 2024 annual meeting, despite strict requirements. 86.

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Article Synopsis
  • The study aims to identify early predictors of cardiotoxicity in lymphoma patients receiving doxorubicin, using 2D-Echo global longitudinal strain (GLS) and cardiac biomarkers.
  • Among 40 evaluated patients, 7.5% developed cardiotoxicity, with older age and higher hypertension rates linked to increased risk.
  • A drop in GLS of more than 15% after three chemotherapy cycles is a significant predictor of potential cardiac dysfunction, while cardiac biomarkers did not effectively indicate cardiotoxicity.
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In heart failure, sympathetic overdrive is evidenced by norepinephrine spillover, receptor level changes, etc. Beta-blockers continue to be the cornerstone of treatment in patients with chronic heart failure due to their ability to counteract sympathetic overdrive. Extensive clinical research has demonstrated that long-term beta-blocker treatment with metoprolol succinate, carvedilol, or bisoprolol enhances left ventricular function and reverses left ventricular remodeling, decreases hospitalization risk, and increases survival.

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Invasive breast cancer (IBC) is a significant health concern globally, contributing to substantial morbidity and mortality among women. Dysregulated cellular proliferation, a hallmark of malignancy, involves molecular pathways modulated by proteins such as cyclin D1 and p16. Understanding their roles in IBC pathogenesis and their association with prognostic parameters is crucial for refining treatment strategies.

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Breast cancer is trending its way as the most common cancer globally. Surgery remains the mainstream treatment modality. The gene expression signatures predict the prognosis in cancer patients.

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Breast cancer remains a significant cause of mortality globally, necessitating effective treatment strategies. Neoadjuvant chemotherapy (NAC) is widely employed to minimize tumor burden and prevent local spread, with treatment efficacy varying based on molecular subtypes. Despite advancements, resistance to conventional therapies persists, prompting the exploration of alternative approaches, including immune cell therapy.

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Background The petrous part of the temporal bone plays a crucial role in various cranial surgical approaches, particularly those involving the middle cranial fossa. Understanding the morphometry of this region is essential for minimizing intraoperative risks and enhancing surgical outcomes. This study aims to provide a detailed morphometric analysis of the petrous bone and its anatomical landmarks in an Indian population, addressing a gap in the literature.

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The umbilical vein can be reliably used for central venous access in neonates less than 14 days old. The catheter used in the umbilical vein normally extends proximally to the inferior vena cava and can be utilized for drug delivery as well as venous sampling. Herein, we describe a neonate with a broken umbilical vein catheter (UVC) stuck in the right atrium and inferior vena cava (IVC), and its successful, uneventful removal via the transfemoral route.

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Background Magnetic resonance imaging (MRI) arthrography has been a mainstay in the diagnosis of musculoskeletal (MSK) joint-related pathology for decades. With the advent of MRI and further advancements incorporating powerful magnetic fields, the radiological landscape is undergoing a shift. The objective of this study is to evaluate the relevance and preference for MRI arthrography versus MRI among MSK radiologists in our current clinical practice across a range of geographic locations.

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MALAT1 is important for facilitating HIV-1 latency reversal in latently infected monocytes.

Gene

February 2025

Laboratory of AIDS Research and Immunology, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India. Electronic address:

Long non-coding RNAs (lncRNAs) are long RNA transcripts with length >200 nucleotides that do not encode proteins. They play a crucial role in regulating HIV-1 infection, yet their involvement in myeloid cells remains underexplored. Myeloid cells are susceptible to HIV infection and contribute substantially to the latent HIV reservoir.

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Introduction And Importance: Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms, initially described in the pleura but capable of arising in various anatomical locations, including the central nervous system. Dedifferentiation, characterized by the transformation of a low-grade tumor into a high-grade sarcoma, is an uncommon phenomenon in SFTs, especially in the intracranial region.

Case Presentation: A 31-year-old male visited the neurology outpatient department with complaints of frequent headaches, seizures, speech difficulties, and weakness on the left side of his body.

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Background: The medial collateral ligament (MCL) is frequently involved in injuries around the knee but is uncommonly treated surgically. There are various techniques to reconstruct the medial side of the knee, which have varying outcomes.

Purpose/hypothesis: The purpose of the present systematic review and meta-analysis is to describe the clinical results of surgical management of acute and chronic isolated grade III MCL injury using various functional scores, such as IKDC, Lysholm, and VAS, and to ascertain complication rates associated with these interventions.

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Background: Only a few studies have systematically assessed sexual dysfunction and marital adjustment in married men with alcohol dependence in India.

Aim: To assess the prevalence and pattern of sexual dysfunction and marital adjustment in a clinical sample of married men with alcohol dependence. The association of sexual dysfunction and marital adjustment with the severity of alcohol dependence was also explored.

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Analysis of the quality of information provided by "Dr. YouTube™" on premature ejaculation.

Ind Psychiatry J

August 2024

Department of Psychiatry, Patan Academy of Health Sciences, School of Medicine, Lalitpur, Nepal.

Article Synopsis
  • YouTube is a widely used resource for health information, but the quality of this information, particularly about premature ejaculation (PME) treatments, has not been properly evaluated.
  • A study assessed 151 YouTube videos in Hindi and English using specific tools to measure the quality and reliability of the information presented, revealing that common treatments included Kegel exercises and antidepressants.
  • The findings indicated that while two-thirds of the videos were generally understandable, only a small percentage provided high-quality information, highlighting the need for healthcare professionals to guide patients towards reliable online health resources.
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Background This study aimed to evaluate tumor-infiltrating lymphocytes (TILs) as predictors of response to neoadjuvant chemotherapy (NACT) in patients with locally advanced breast cancer (LABC). Methods Overall, 35 patients with LABC were included in the study. Information on demographic profile, medical history, and signs and symptoms was collected for each patient, and a complete clinical evaluation was conducted, which involved physical examination, imaging studies (mammogram/ultrasound imaging), biopsy of each patient, and a metastatic workup.

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