Comparing supine CT scanogram and standing long-leg radiograph for postoperative alignment in total knee arthroplasty: a prospective study.

Purpose: Achieving precise postoperative alignment is critical for the long-term success of total knee arthroplasty (TKA). Long-leg standing radiograph (LLR) at 6 weeks post-op is the gold standard for assessing alignment, but its reliance on weight-bearing and positioning makes it less practical in the early postoperative period. Supine computed tomography scanogram (CTS) offers a potential alternative.

A systematic review and meta-analysis of efficacy of vasopressin as a vasoconstrictive and uterotonic drug in laparoscopic myomectomy.

Introduction: Laparoscopic myomectomy is a commonly performed operation with fast recovery and excellent results. However, haemorrhagic nature of the operation mandates us to use variety of vasoconstrictive and uterotonic agents. Amongst which, one of them is vasopressin.

Anticipating Urgency: Predictive Factors for Early Intervention in Appendicular Perforation.

Background: Appendicular perforation is a severe complication of acute appendicitis, leading to increased morbidity and complex post-surgical outcomes. Early identification of patients at risk of perforation is crucial to improve clinical management and reduce complications. This study aims to review and summarize the predictive value of clinical, biochemical, and radiological factors in determining the likelihood of appendicular perforation.

Bilateral ovarian mature cystic teratoma with unilateral malignant transformation to adenocarcinoma: A case report.

Mature cystic teratoma (MCT) is the most common germ cell tumor of the ovary, comprising 20% of all ovarian neoplasms. Malignant transformation (MT) is an uncommon complication and occurs in approximately 1-3% of all MCTs. The most common histological type of MT is squamous cell carcinoma.

Prevalence and Patterns of Polysubstance Use (Tobacco and Other Substances) and Associated Factors: A Cross-Sectional Analysis in a High-Risk Cohort for Oral Cancer in Varanasi, India, with a Special Focus on Young Emerging Adults.

Introduction: The dearth of population-based data on polysubstance use, especially in young emerging adults, presents a critical gap in understanding public health challenges, particularly in rural India, where tobacco and oral cancer are prevalent. This study addresses this gap by investigating the prevalence and patterns of substance use, with a focus on young emerging adults (18-29 years) within a high-risk cohort for oral cancer in Varanasi, India.

Methods: The study involved a cross-sectional analysis of baseline data from 10,101 participants within a high-risk cohort in rural settings of the Varanasi district between December 2020-June 2023.

A rare case of dedifferentiated intracranial solitary fibrous tumor with chondrosarcomatous differentiation.

This report details a rare case of a 30-year-old female presenting with neurological symptoms, including headaches, seizures, and left-sided weakness. Imaging revealed a mass in the right parafalcine region of her brain. Surgical resection identified a tumor with two distinct components.

Angiotensin receptor neprilysin inhibitor in chronic heart failure and comorbidity management: Indian consensus statement.

Heart failure (HF) is a significant public health concern characterized by notable rates of morbidity and mortality. Multimorbidity, ranging from 43% to 98% among HF patients, significantly impacts prognosis and treatment response. HF management requires a holistic approach, including guideline-directed medical therapy.

A Rare Case of Inflammatory Cardiac Mass in the Young: Diagnostic Uncertainty and Therapeutic Challenges.

Inflammatory cardiac masses are rare and often mimic neoplastic or thrombotic lesions, posing significant diagnostic challenges. These masses are typically identified incidentally during imaging studies, such as echocardiography, and further evaluation with cardiac magnetic resonance imaging (MRI) is required for accurate tissue characterization. Early recognition and appropriate management are crucial to prevent complications.

Adjuvant Therapy for Endometrial Cancer in the Era of Molecular Classification.

Endometrial cancer primarily undergoes surgical intervention, with adjuvant treatments such as external beam pelvic radiotherapy, vaginal brachytherapy, chemotherapy, and combined therapy investigated in randomized trials. Treatment decisions hinge on clinicopathological risk factors. Low-risk cases usually require surgery alone, whereas high-intermediate risk often benefit from adjuvant vaginal brachytherapy for enhanced local control with minimal side effects.

Predicting unicompartmental arthroplasty success: a three year Indian study.

Purpose: This study evaluated the three year clinical outcomes and predictors of success for unicompartmental knee arthroplasty (UKA) in an Indian population.

Methods: Twenty patients with medial compartment osteoarthritis (≥ Ahlbäck grade 2) underwent UKA. American Knee Society Score (AKSS), Oxford Knee Score (OKS), and Visual Analogue Scale Score (VAS) were assessed at baseline, two weeks, six weeks, three months, and three years.

Isolated plasmacytoma of the breast: A rare case report.

Introduction And Importance: Solitary plasmacytoma of the breast is an extremely rare manifestation of plasma cell neoplasms, predominantly seen in the bone marrow and commonly associated with multiple myeloma. When it occurs as an isolated lesion in the breast, it presents unique diagnostic and therapeutic challenges due to its rarity and clinical similarity to other breast conditions.

Case Presentation: We report a case of a 60-year-old female presenting with a gradually enlarging mass in her right breast over six months.

Comparison of the Analgesic Efficacy of Ultrasound-Guided Transperineal Approach Using Pudendal Nerve Block Versus Caudal Block in Children Undergoing Urological Surgeries: A Randomized Controlled Trial.

Introduction: Caudal block is an effective regional anesthesia technique for perineal surgeries but is associated with various adverse effects. Recently, pudendal nerve block has emerged as a promising alternative for these procedures. This study assessed the effectiveness of a novel transperineal technique for ultrasound-guided pudendal nerve block and compares it with ultrasound-guided caudal block for perineal surgeries in pediatric patients.

Effects of Revascularization on Cardiac Autonomic Neuropathy in Type 2 Diabetes Mellitus Patients With Chronic Stable Angina.

Background: Type 2 diabetes mellitus (T2DM) leads to cardiac autonomic neuropathy (CAN), affecting blood flow and heart rate regulation eventually causing chronic stable angina (CSA). Percutaneous coronary intervention (PCI) can correct autonomic dysfunctions and improve myocardial perfusion. This study aimed to assess CAN using heart rate variability (HRV) and cardiovascular reflex tests in T2DM patients with CSA before and after PCI.

Tuberculous parotitis: A case series diagnosed on fine needle aspiration.

Introduction: Tuberculosis (TB) remains a global health concern with diverse clinical manifestations. Parotid tuberculosis, although rare, presents diagnostic challenges due to its atypical presentation. Cytological examination is pivotal in diagnosing parotid lesions.

Accuracy of Financial Disclosures by Scientific Presenters/Authors at the ASNR 2024 annual meeting.

Physician-industry financial relationships can drive research and innovation, improving patient care and outcomes, but potentially raise ethical concerns if not disclosed appropriately. This study shows high rates of non-disclosures by authors/presenters at the ASNR 2024 annual meeting, despite strict requirements. 86.

Incidence, Risk Factors and Early Prediction of Doxorubicin-Induced Cardiotoxicity by Global Longitudinal Strain and Cardiac Biomarkers in Indian Patients With Lymphoma: A Prospective Observational Study.

Background: Detecting anthracyclines-induced cardiotoxicity before the onset of left ventricular dysfunction could enable the timely initiation of cardioprotective measures. 2D-Echocardiography (ECHO) with global longitudinal strain (GLS) and cardiac biomarkers are valuable for the early prediction of cardiotoxicity.

Objectives: We aimed to evaluate the predictive utility of 2D-ECHO-GLS and cardiac biomarkers exclusively in patients with lymphoma treated with a doxorubicin-based regimen.

Sympathetic Overdrive and Role of Beta-blockers in Various Forms of Heart Failure: A Consensus Statement from India.

In heart failure, sympathetic overdrive is evidenced by norepinephrine spillover, receptor level changes, etc. Beta-blockers continue to be the cornerstone of treatment in patients with chronic heart failure due to their ability to counteract sympathetic overdrive. Extensive clinical research has demonstrated that long-term beta-blocker treatment with metoprolol succinate, carvedilol, or bisoprolol enhances left ventricular function and reverses left ventricular remodeling, decreases hospitalization risk, and increases survival.

Immunohistochemical Expression of Cyclin D1 and p16 in Invasive Breast Carcinoma and Its Association with Clinicopathological Parameters.

Invasive breast cancer (IBC) is a significant health concern globally, contributing to substantial morbidity and mortality among women. Dysregulated cellular proliferation, a hallmark of malignancy, involves molecular pathways modulated by proteins such as cyclin D1 and p16. Understanding their roles in IBC pathogenesis and their association with prognostic parameters is crucial for refining treatment strategies.

Expression of EMT Markers Snail, Slug, and Twist and their Association with Known Prognostic Indicators of Breast Cancer.

Breast cancer is trending its way as the most common cancer globally. Surgery remains the mainstream treatment modality. The gene expression signatures predict the prognosis in cancer patients.

Evaluating the Clinico-Pathological Relationship Between Stromal Tumor-Infiltrating Lymphocytes and Androgen Receptor Expression Across Molecular Subtypes of Invasive Breast Carcinoma.

Breast cancer remains a significant cause of mortality globally, necessitating effective treatment strategies. Neoadjuvant chemotherapy (NAC) is widely employed to minimize tumor burden and prevent local spread, with treatment efficacy varying based on molecular subtypes. Despite advancements, resistance to conventional therapies persists, prompting the exploration of alternative approaches, including immune cell therapy.

Morphometric Analysis of Petrous Bone With Emphasis on Landmarks Utilized in Lateral Skull Base Approaches.

Background The petrous part of the temporal bone plays a crucial role in various cranial surgical approaches, particularly those involving the middle cranial fossa. Understanding the morphometry of this region is essential for minimizing intraoperative risks and enhancing surgical outcomes. This study aims to provide a detailed morphometric analysis of the petrous bone and its anatomical landmarks in an Indian population, addressing a gap in the literature.