A Safe Framework for Quantitative In Vivo Human Evaluation of Image Guidance.

We present a new framework for in vivo image guidance evaluation and provide a case study on robotic partial nephrectomy. This framework (called the "bystander protocol") involves two surgeons, one who solely performs the therapeutic process without image guidance, and another who solely periodically collects data to evaluate image guidance. This isolates the evaluation from the therapy, so that in-development image guidance systems can be tested without risk of negatively impacting the standard of care.

Active sites of atomically dispersed Pt supported on Gd-doped ceria with improved low temperature performance for CO oxidation.

"Single - atom" catalysts (SACs) have been the focus of intense research, due to debates about their reactivity and challenges toward determining and designing "single - atom" (SA) sites. To address the challenge, in this work, we designed Pt SACs supported on Gd-doped ceria (Pt/CGO), which showed improved activity for CO oxidation compared to its counterpart, Pt/ceria. The enhanced activity of Pt/CGO was associated with a new Pt SA site which appeared only in the Pt/CGO catalyst under CO pretreatment at elevated temperatures.

Reversible Cl/Cl redox in a spinel MnO electrode.

A unique prospect of using halides as charge carriers is the possibility of the halides undergoing anodic redox behaviors when serving as charge carriers for the charge-neutrality compensation of electrodes. However, the anodic conversion of halides to neutral halogen species has often been irreversible at room temperature due to the emergence of diatomic halogen gaseous products. Here, we report that chloride ions can be reversibly converted to near-neutral atomic chlorine species in the MnO electrode at room temperature in a highly concentrated chloride-based aqueous electrolyte.

Manifestation of the interplay between spin-orbit and Jahn-Teller effects in Au superatom UV-Vis fingerprint spectra.

Atomically precise nanoclusters play an important role in nanoscale catalysis, photonics, and quantum information science. Their nanochemical properties arise from their unique superatomic electronic structures. As the flagship of atomically precise nanochemistry, the Au(SR) nanocluster exhibits tunable spectroscopic signatures that are sensitive to the oxidation state.

N-oxide ligands for selective separations of lanthanides: insights from computation.

Preorganized ligands such as bis-lactam-1,10-phenanthroline (BLPhen) show unique selectivity trends across the lanthanide series, indicating the synergistic effects of both N and O donors in complexing with lanthanides. We hypothesize that by replacing amide functional groups with an N-oxide functionality would open the door to new ligand architectures with improved selectivities. To test this idea, we computationally examined mixed N,O-donor ligands containing pyridinic N and N-oxide groups and evaluated their relative aqueous La(iii)/Ln(iii) selectivity by computing free energy changes for the exchange reaction between the designed ligands and a reference ligand.

Reassessment of N activation by low-valent Ti-amide complexes: a remarkable side-on bridged bis-N adduct is actually an arene adduct.

The complex {(TMEDA)Li}{[Ti(N(TMS))](μ-η:η-N)} (5-Li) is the only transition metal N complex ever reported with two side-on N adducts. In this report, the similarity of 5-Li to a new inverse sandwich toluene adduct {(PhMe)K}{[Ti(N(TMS))](μ-PhMe)} (6-K) necessitated a re-examination of the structure of 5-Li. Through a reassessment of the original disordered crystal data of 5-Li and new independent syntheses brought about through revisitation of the original reaction conditions, 5-Li has been re-assigned as an inverse sandwich toluene adduct, {(TMEDA)Li}{[Ti(N(TMS))](μ-PhMe)} (6-Li).

Phase-engineered high-entropy metastable FCC Cu Ag (In Sn )SeS nanomaterials with high thermoelectric performance.

Crystal-phase engineering to create metastable polymorphs is an effective and powerful way to modulate the physicochemical properties and functions of semiconductor materials, but it has been rarely explored in thermoelectrics due to concerns over thermal stability. Herein, we develop a combined colloidal synthesis and sintering route to prepare nanostructured solids through ligand retention. Nano-scale control over the unconventional cubic-phase is realized in a high-entropy Cu Ag (In Sn )SeS ( = 0-0.

Leveraging the gel-to-sol transition of physically crosslinked thermoresponsive polymer hydrogels to enable reactions induced by lowering temperature.

Much work has been done on the use of heating to trigger reactions the temperature-dependent removal of a barrier or constraint separating reagents. Far less work, however, has been done on the use of cooling to achieve a similar goal. Numerous applications, such as those involving components or materials susceptible to persistent low temperatures and cases in which energy for heating is not available, would benefit from this inverse approach.

Probing metabolic alterations in breast cancer in response to molecular inhibitors with Raman spectroscopy and validated with mass spectrometry.

Rapid and accurate response to targeted therapies is critical to differentiate tumors that are resistant to treatment early in the regimen. In this work, we demonstrate a rapid, noninvasive, and label-free approach to evaluate treatment response to molecular inhibitors in breast cancer (BC) cells with Raman spectroscopy (RS). Metabolic reprogramming in BC was probed with RS and multivariate analysis was applied to classify the cells into responsive or nonresponsive groups as a function of drug dosage, drug type, and cell type.

Optimization of electron beam-deposited silver nanoparticles on zinc oxide for maximally surface enhanced Raman spectroscopy.

Surface enhanced Raman spectroscopy enables robust, rapid analysis on highly dilute samples. To be useful, the technique needs sensing substrates that will enhance intrinsically weak Raman signals of trace analytes. In particular, three-dimensional substrates such as zinc oxide nanowires decorated with electron-beam deposited silver nanoparticles are easily fabricated and serve the dual need of structural stability and detection sensitivity.

monitoring of electrical and optoelectronic properties of suspended graphene ribbons during laser-induced morphological changes.

Exploring ways to tune and improve the performance of graphene is of paramount importance in creating functional graphene-based electronic and optoelectronic devices. Recent advancements have shown that altering the morphology of graphene can have a pronounced effect on its properties. Here, we present a practical and facile method to manipulate the morphology of a suspended graphene ribbon using a laser to locally induce heating while monitoring its electrical and optoelectronic properties .

Sub-3 nm Intermetallic Ordered PtIn Clusters for Oxygen Reduction Reaction.

Industrial applications of Pt-based oxygen-reduction-reaction (ORR) catalysts are limited by high cost and low stability. Here, facile large-scale synthesis of sub-3-nm ordered PtIn clusters on commercial carbon black as ORR catalyst that alleviates both these shortcomings is reported. As-prepared PtIn/C exhibits a mass activity of 0.

Emerging Diluted Ferromagnetism in High- Superconductors Driven by Point Defect Clusters.

Defects in ceramic materials are generally seen as detrimental to their functionality and applicability. Yet, in some complex oxides, defects present an opportunity to enhance some of their properties or even lead to the discovery of exciting physics, particularly in the presence of strong correlations. A paradigmatic case is the high-temperature superconductor YBaCuO (Y123), in which nanoscale defects play an important role as they can immobilize quantized magnetic flux vortices.