The effect of climate crisis on bipolar disorder: A qualitative study about experiences of individuals diagnosed with bipolar disorder.

Introduction: It can be said that the bipolar disorder is influenced by weather events. It is stated that climate change can have direct and indirect effects on bipolar disorder. Determining the impact of the climate crisis on individuals with bipolar disorder may assist in the development of preventive, protective and active treatment interventions for this group.

The effect of use of Ni/Fe and mZVI on phenol removal with the heterogenous fenton process and in-situ generation of HO.

To degrade phenol with the heterogeneous Fenton-like process and to compare the results, micro-scale zero-valent iron particles (mZVI) and nickel-coated iron bimetallic particles (Ni/Fe) were used. Oxygen was given to the system and converted to HO and •OH radicals. The changes in the properties of mZVI and Ni/Fe particles after the reaction were determined by scanning electron microscope (SEM), X-ray energy-dispersive spectrometer (EDX), Brunauer-Emmett-Teller (BET), X-ray powder diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) before and after the reaction.

Comparison of AI-assisted cephalometric analysis and orthodontist-performed digital tracing analysis.

Background: The aim of this study was to compare and evaluate three AI-assisted cephalometric analysis platforms-CephX, WeDoCeph, and WebCeph-with the traditional digital tracing method using NemoCeph software.

Material And Method: A total of 1500 lateral cephalometric films that met the inclusion criteria were classified as Class I, Class II, and Class III. Subsequently, 40 patients were randomly selected from each class.

Evaluation of Placentome Morphology in the Last Two Periods of Pregnancy in Hair Goats (Capra aegagrus hircus).

This study was carried out on pregnant uteruses obtained from healthy Hair goats (Capra aegagrus hircus). A total of thirteen pregnant uteruses, six second and seven third trimesters, were used. Morphometrically, placentome numbers, lengths, widths and depths were measured.

The Apoptotic, Cytotoxic, and Anti-migration Effects of Sodium Deoxycholate in a Breast Cancer Cell Line and its Modulation on PON1 as a Predictive Risk Marker.

Introduction: Breast cancer is the most prevalent cancer among women and is usually treated with antineoplastic drugs. The present study examines the influence of sodium deoxycholate on the molecular pathways underlying apoptosis, cytotoxicity, and the modulation of PON1 in the MCF-7 breast cancer cell line. Various doses were administered to test the hypothesis that it could potentially affect cancer cells.

Mitochondrial toxicity of selected natural compounds: assessment and molecular docking and dynamics simulation.

Boiss & Hausskn stands out for its rich bioactive constituents including prantschimgin (PRA), imperatorin (IMP), suberosin (SUB), adicardin (ADI), and oxypeucedanin hydrate (OPH) in the Apiaceae family. Although these molecules contribute to several biological activities, their mitochondrial toxicity were not illuminated in depth with the appropriate and models. Cell viability studies investigated the cytotoxic activities of molecules in HepG2 cells by replacing glucose with galactose due to Warburg effects.

Effects of Boron on Learning and Behavioral Disorders in Rat Autism Model Induced by Intracerebroventricular Propionic Acid.

Autism spectrum disorder is a neurodevelopmental disorder in which learning, communication, and social interaction are impaired. Research has sought to minimize the neural impairments associated with autism spectrum disorder and improve the quality of life. Recent studies suggest that boron may benefit nerve cells, with effects varying depending on the dosage.

Determination of complementary and alternative medicine use frequency and related factors in children with epilepsy: A descriptive Cross-Sectional study from eastern Turkey.

Purpose: The aim of this study is to determine the complementary and alternative medicine (CAM) methods used in epilepsy patients admitted to a paediatric neurology clinic in Turkey and to examine the factors affecting these methods.

Methods: This study was conducted between October 2022 and March 2023 by using a questionnaire form prepared in line with the literature to the parents (n = 172) of children who were under the age of 18 and who had been diagnosed with epilepsy for at least 1 year and who were followed up in the paediatric neurology outpatient clinic of a secondary care hospital in Van province of Turkey. The principles of scientific ethics and confidentiality of data were complied with in all stages of the study.

The Influence of Modeling Liquid on Microhardness of Single-Shade Composite Resins: An Study.

Aim: To assess the effect of modeling liquid on the microhardness of single-shade universal composites.

Materials And Methods: A total of 60 disk-shaped samples were prepared in six groups [Omnichroma (OM), Essentia Universal (EU), Vittra APS Unique (VA), OM + Signum, EU + Signum, and VA + Signum] for surface microhardness measurements. Samples were stored in a coffee solution for 7 days and after that bleached with an Office bleaching agent (Total Blanc Office).

Discovery of New Pyrazole-Tosylamide Derivatives as Apoptosis Inducers Through BCL-2 Inhibition and Caspase-3 Activation.

In this presented study, a series of new carbonitrile-substituted pyrazole-tosyl amide derivatives were designed and synthesized according to previous studies. The antiproliferative effects of the synthesized compounds on MDA-MB-231, MCF-7, HepG2, PC-3, and A549 cancer cell lines were assessed by MTT assay compared with non-cancerous cells. The results demonstrate that compounds 9d, 9e, and 9f had a higher antiproliferative effect (IC <10 μM) against both breast cancer cells.

Caffeine mitigates tamoxifen-induced fatty liver in Wistar rats.

Purpose: Tamoxifen, a widely used drug for breast cancer treatment, is associated with adverse effects on the liver, including the development of fatty liver. This study aimed to investigate the potential protective effect of caffeine against tamoxifen-induced fatty liver in Wistar rats.

Methods: Rats were divided into normal control, tamoxifen + saline, and tamoxifen + caffeine.

Aggregate Index of Systemic Inflammation: The Strongest Predictor of In-Hospital Venous Thromboembolism Events among Patients Hospitalized for Trauma or Surgery.

Background: To investigate the power of inflammation/immune indices in-hospital deep vein thrombosis (DVT) and any venous thromboembolism (VTE) event (VTE: DVT + pulmonary embolism [PE]) that may occur after trauma or surgery and to identify the strongest predictors.

Methods: This was a retrospective study conducted between January 2020 and December 2022. A total of 216 patients with suspicion of DVT or PE during their hospital stay for trauma or surgery were included in the study.

Effectiveness of Mulligan Mobilization Technique and Core Stabilization Exercises in Female Patients With Knee Osteoarthritis: A Randomized Controlled Single-Blind Study.

Objectives: The aim of this study was to compare the effectiveness of the Mulligan mobilization (MM) technique and Core stabilization (CS) exercises added to the conventional physiotherapy (CP) program in female patients with knee osteoarthritis (KOA).

Methods: The study included 42 female patients diagnosed with bilateral KOA. Participants were randomly divided into 3 groups as CP group (mean age: 57.

Hematologic Inflammation Indices for Differentiating between Brucella, Pyogenic, and Tuberculous Spondylodiscitis.

Infectious spondylodiscitis is a life-threatening disease and has some challenges in terms of diagnostic, differentiative, and therapeutic processes. Therefore, rapid and effective management of infectious spondylodiscitis is necessary. Hematological inflammation indices (HIIs) such as the neutrophil/lymphocyte ratio and aggregate index of systemic inflammation are derived from blood cells and used as diagnostic, prognostic, predictive, and treatment monitoring indicators.

Effects of exogenous ghrelin treatment on oxidative stress, inflammation and histological parameters in a fat-fed streptozotocin rat model.

In this study, the anti-inflammatory, antioxidative, and protective effects of ghrelin were investigated in a fat-fed streptozotocin (STZ) rat model and compared with metformin, diabetes and the healthy control groups. Histopathological evaluations were performed on H&E-stained pancreas and brain sections. Biochemical parameters were investigated by enzyme-linked immunosorbent assay.

Difficulties in emotion regulation and attachment styles among Kurdish individuals in Eastern Turkey with substances use disorders.

The aim of this study was to investigate the relationship between attachment style and emotion dysregulation in Kurdish individuals with substance use disorders (SUDs) in Eastern Turkey, a non-Western, Islamic society, in a descriptive cross-sectional design. This study was conducted with 216 individuals with SUDs who were treated at the SBU Van Training and Research Hospital Alcohol and Substance Addiction Treatment Center in Eastern Turkey between April 2023 and June 2023. Almost half of the participants (44.