Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis.

Purpose: Malignant peripheral nerve sheath tumors (MPNST) are highly aggressive soft-tissue sarcomas that lack effective treatments, underscoring the urgent need to uncover novel mediators of MPNST pathogenesis that may serve as potential therapeutic targets. Tumor angiogenesis is considered a critical event in MPNST transformation and progression. Here, we have investigated whether endoglin (ENG), a TGFβ coreceptor with a crucial role in angiogenesis, could be a novel therapeutic target in MPNSTs.

Locally destructive mandibular pseudotumor as a manifestation of immunoglobulin G4-related disease.

Immunoglobulin G4-related disease is a recently identified entity. The cervicofacial location is not frequent. We report the case of a patient with an inflammatory pseudotumor in the mandible, who had to undergo surgery for diagnosis.