14 results match your criteria: "Vall d'Hebron Barcelona Hospital Campus. Barcelona[Affiliation]"
SGLT2i and GLP1-RA exert additive cardiorenal protection with a RAS blocker in uninephrectomized db/db mice.
Front Pharmacol
October 2024
Nephrology and Transplantation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Nephrology Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
Introduction: Diabetic Kidney Disease (DKD) is the main cause of end-stage renal disease in the developed world. The current treatment of the DKD with renin-angiotensin system (RAS) blockade does not totally halt the progression to end stage kidney disease. Currently, several drugs have shown to delay DKD progression such as sodium-glucose co-transporter-2 inhibitors (SGLT2i) and glucagon-like-1 receptor agonists (GLP-1RA).
View Article and Find Full Text PDFImmune-monitoring of myelodysplastic neoplasms: Recommendations from the i4MDS consortium.
Hemasphere
May 2024
Comprehensive Cancer Centre, King's College London UK.
Article Synopsis
- Advancements in understanding myelodysplastic neoplasms (MDS) have revealed important cellular and molecular factors that influence disease progression, highlighting the significance of immune dysregulation in the bone marrow during MDS evolution.
- Despite these advancements, immunotherapy for MDS has lagged due to a lack of effective immune classifications for patient stratification and no widely accepted immune panels for clinical use.
- To address these challenges, the i4MDS consortium proposes standardized immune monitoring approaches, including flow cytometry panels and cytokine assays, aiming to improve patient stratification and develop predictive markers for treatment response in MDS.
Integrating AIPSS-MF and molecular predictors: A comparative analysis of prognostic models for myelofibrosis.
Hemasphere
March 2024
Hospital Clínico Universitario-INCLIVA, University of Valencia Valencia Spain.
Key Clinical Message: The increased life expectancy in patients with hemophilia (PwH) over the last years has raised the incidence of comorbidities, including thromboembolic events. Thromboembolic events are rare in PwH and most of them occur in the presence of exogenous risk factors. There is still scarce scientific evidence on the optimal antithrombotic treatment and management approach in this population.
View Article and Find Full Text PDFEarly-Stage Breast Cancer Detection in Breast Milk.
Cancer Discov
October 2023
Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus. Barcelona, Spain.
Article Synopsis
- Breast cancer diagnosed during pregnancy (PrBC) and postpartum (PPBC) tends to be found at more advanced stages, leading to a poorer prognosis, especially with PPBC being very aggressive.
- Researchers discovered that cell-free tumor DNA (ctDNA) can be detected in breast milk (BM) from breast cancer patients, showing higher detection rates compared to plasma samples.
- This study suggests that using BM for ctDNA analysis could serve as a novel liquid biopsy method, allowing for earlier detection of breast cancer, even months before standard diagnosis techniques.
The significant IgG4 infiltrate in autoimmune hepatitis is associated with a greater ductular reaction and more advanced liver disease.
Dig Liver Dis
December 2023
Liver Unit, Internal Medicine Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus. Barcelona, Spain; Universitat Autònoma de Barcelona, Department of Medicine, Barcelona, Spain; CIBERehd, Instituto Carlos III, Barcelona, Spain. Electronic address:
Background: Sclerosing cholangitis is the typical IgG4-related disease digestive involvement. However, the role of the IgG4 liver expression in autoimmune hepatitis remains unknown.
Aims: to assess whether the expression of IgG4 plasma cells in patients with autoimmune hepatitis (AIH) was associated with different outcomes.
Introduction: Rare bleeding disorders (RBD) constitute 5% of total hereditary bleeding disorders, although the number could be higher, due to the presence of undiagnosed asymptomatic patients. The objective of this study was to analyze the prevalence and characteristics of patients with severe RBDs in our area.
Material And Methods: We analyzed the patients with RBD followed at a tertiary-level hospital between January 2014 and December 2021.
Half of the myelodysplastic syndromes (MDS) have normal karyotype by conventional banding analysis. The percentage of true normal karyotype cases can be reduced by 20-30% with the complementary application of genomic microarrays. We here present a multicenter collaborative study of 163 MDS cases with a normal karyotype (≥10 metaphases) at diagnosis.
View Article and Find Full Text PDFChronic bronchial infection in stable COPD: To treat or not to treat.
Pulmonology
November 2023
CIBER de Enfermedades Respiratorias (CIBERES), Spain; Pneumology Department, Hospital Universitario y Politécnico La Fe. Valencia, Spain.
Extended half-life FIX (EHL-FIX) concentrates have been developed with the purpose of reducing the frequency of infusions in patients with severe or moderate hemophilia B. We describe the case of a 63-year-old patient with severe hemophilia B (sHB) treated with FIX-Fc fusion protein (rFIXFc) who underwent neurosurgery.
View Article and Find Full Text PDFGenetic diagnosis of basal ganglia disease in childhood.
Dev Med Child Neurol
June 2022
Paediatric Neurology Research Group, Vall d´Hebron Research Institut, Universitat Autònoma de Barcelona, Barcelona, Spain.
Article Synopsis
- * Over two years, researchers analyzed 62 children, finding genetic causes in 30 patients, including mitochondrial diseases and Aicardi-Goutières syndrome, through various sequencing techniques.
- * The study identified three distinct clusters of lesions, and while mitochondrial biomarkers were not very effective, an interferon signature was found in Aicardi-Goutières syndrome cases, leading to the suggestion of using next-generation sequencing for early diagnosis based on these clusters.
A year living with SARS-CoV-2: an epidemiological overview of viral lineage circulation by whole-genome sequencing in Barcelona city (Catalonia, Spain).
Emerg Microbes Infect
December 2022
Respiratory Viruses Unit, Microbiology Department, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus Barcelona, Spain.
Herein, we describe the genetic diversity of circulating SARS-CoV-2 viruses by whole-genome sequencing (WGS) in Barcelona city (Catalonia, Spain) throughout the first four pandemic waves. From weeks 11/2020-24/2021, SARS-CoV-2-positive respiratory samples were randomly selected per clinical setting (80% from primary care or 20% from the hospital), age group, and week. WGS was performed following the ARTICv3 protocol on MiSeq or NextSeq2000 Illumina platforms.
View Article and Find Full Text PDFFetal heart rate monitoring during fetoscopic repair of open spinal neural tube defects: a single-centre observational cohort study.
Int J Obstet Anesth
November 2021
Anaesthesiology and Intensive Care Department. Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Universitat Autònoma de Barcelona, Bellaterra, Spain.
Background: During fetal surgery, the haemodynamic stability of the fetus depends on the haemodynamic stability of the mother. The primary objective of this study was to assess changes in fetal heart rate (FHR) throughout the different stages of surgery. The secondary objective was to assess potential changes in maternal physiological parameters and their association with FHR.
View Article and Find Full Text PDFSeverely damaged lower limb salvage in a critically ill burned patient. Lessons learned.
Int J Burns Trauma
October 2020
Plastic Surgery Department and Burn Center, Vall d'Hebron Barcelona Hospital Campus Barcelona, Spain.
Article Synopsis
- - The article discusses the complex reconstructive challenges faced when salvaging lower limbs in severely burned patients with exposed bone or tendon, especially when standard therapies are inadequate.
- - Microsurgical reconstruction using distant flaps is often the most effective approach for these cases, despite lower success rates due to the severity of the burns.
- - An illustrative case is presented where a patient with extensive electrical injuries underwent multiple surgical interventions, ultimately achieving limb salvation and regaining mobility and quality of life after 3 years.