The association between the type of bystander and survival after an out-of-hospital cardiac arrest: A French nationwide study.

Background: Early bystander interventions are associated with more favorable outcomes after out-of-hospital cardiac arrest (OHCA). The objective of the present study was to determine whether the type of bystander-patient relationship was associated with survival and neurological outcomes after OHCA in France.

Methods: We analyzed data registered in the French National Cardiac Arrest Registry (RéAC) between July 1st, 2011, and April 30th, 2023.

Intrinsic gallium-68 labeling of nanoclays for tracking.

Intrinsic gallium-68 labeling of nanoclays was developed with high labeling yield and radiostability that did good for their tracking.Image 1.

Blocking the adverse outcome pathway of skin sensitization through a -acetyl cysteine and lysine-loaded hydrogel.

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Comparative efficacy of repurposed drugs lopinavir-ritonavir and darunavir-ritonavir in hospitalised COVID-19 patients: insights from a tertiary centre cohort.

Background: Drug repurposing has become a widely adopted strategy to minimise research time, costs, and associated risks. Combinations of protease inhibitors such as lopinavir and darunavir with ritonavir have been repurposed as treatments for COVID-19. Although lopinavir-ritonavir (LPV/r) and darunavir-ritonavir (DRV/r) have shown efficacy against COVID-19, the results in human studies have been inconsistent.

Preparation and evaluation of T4SS recombinant proteins in serodiagnosis of human brucellosis based on TMT-based proteomics technology.

Introduction: Brucellosis, a significant zoonotic infectious disease, poses a global health threat. Accurate and efficient diagnosis is crucial for prevention, control, and treatment of brucellosis. VirB proteins, components of the Type IV secretion system (T4SS) in , play a pivotal role in bacterial virulence and pathogenesis but have been understudied for their diagnostic potential.

Identifying key blood markers for bacteremia in elderly patients: insights into bacterial pathogens.

Background: This study aimed to assess the distribution of bacteremia pathogens in elderly patients, examine the impact of gender on pathogen distribution, and evaluate the predictive value of routine blood parameters for diagnosing bacteremia.

Methods: A retrospective analysis was conducted on 151 elderly patients (≥60 years old) admitted to Fuding Hospital, Fujian University of Traditional Chinese Medicine between October 2022 and June 2023. Comprehensive routine blood tests and blood cultures were performed.

Clinical evaluation of a multiplex droplet digital PCR for diagnosing suspected bloodstream infections: a prospective study.

Background: Though droplet digital PCR (ddPCR) has emerged as a promising tool for early pathogen detection in bloodstream infections (BSIs), more studies are needed to support its clinical application widely due to different ddPCR platforms with discrepant diagnostic performance. Additionally, there is still a lack of clinical data to reveal the association between pathogen loads detected by ddPCR and corresponding BSIs.

Methods: In this prospective study, 173 patients with suspected BSIs were enrolled.

Exploring the composition of placental microbiome and its potential origin in preterm birth.

Introduction: For years, the placenta was believed to be sterile, but recent studies reveal it hosts a unique microbiome. Despite these findings, significant questions remain about the origins of the placental microbiome and its effects on pregnancy and fetal health. Some studies suggest it may originate from the vaginal tract, while others indicate that oral bacteria can enter the maternal bloodstream and seed the placenta.

Effect of invasive tests during pregnancy on perinatal transmission of hepatitis B infection: a scoping review.

Prenatal and intrapartum invasive tests are possible mechanisms of mother to child transmission (MTCT) of hepatitis B virus (HBV). The viral activity can affect the MTCT risk after invasive tests, but the evidence is scarce. This scoping review discussed the effects of prenatal or intrapartum invasive tests on the risk of HBV MTCT.

National Patient Satisfaction Survey as a Predictor for Quality of Care and Quality Improvement - Experience and Practice.

Background: Patient satisfaction is an important predictor of quality of care and hospital services. Patient satisfaction survey provides not only valuable insight into patient experience of care but also evidence that guides quality improvement in both system and organization levels. The paper aims to prove the value of system-wide satisfaction survey of patients and demonstrate whether data collected from a national patient satisfaction survey in three-year period can predict trends in patient experience of care.

Reporting on knowledge, attitudes, and behaviours of pharmacists regarding the active offer of French language health services in Ontario: A quantitative survey study.

Background: Patient-provider language discordances can negatively affect the availability, accessibility, acceptability, and quality (AAAQ) of pharmacy services as described by the AAAQ framework. With nearly 600,000 residents of Ontario identifying French as their mother tongue, the active offer (AO) of French language pharmacy services should be provided, yet little is known about pharmacists' familiarity and use of AO.

Methods: Ontario pharmacists completed an online survey measuring their knowledge, attitudes, and behaviours (KAB) regarding the AO for French language services (FLS).

Novel 'mini-incision' metacarpal fixation technique for long oblique and spiral shaft fractures.

Background: Metacarpal shaft fractures account for 30 % of all hand fractures, and long oblique and spiral shaft fractures represent a significant quantity. Closed or open reduction and internal fixation is generally indicated for unstable fractures, rotational malalignment or significant metacarpal shortening. Various techniques can achieve appropriate fixation, though no single technique has been proven to be superior across all cases.

Chiral polymer-induced hydroxyapatite for promoting bone regeneration.

Chirality is one of the basic characteristics of living matter, yet the effect of chiral polymers on osteogenesis is seldom studied. Thus, it is necessary to deeply recognize the behaviors of chiral polymers in osteogenic processes, which can be beneficial for the development of bone repair materials. In this work, chiral hydroxyapatite (HAP) was constructed simply using poly(levorotatory/dextral-tartaric acid) as the guest of the chiral transfer system.

Hydrogel inspired by "adobe" with antibacterial and antioxidant properties for diabetic wound healing.

With the aging population, the incidence of diabetes is increasing. Diabetes often leads to restricted neovascularization, antibiotic-resistant bacterial infections, reduced wound perfusion, and elevated reactive oxygen species, resulting in impaired microenvironments and prolonged wound healing. Hydrogels are important tissue engineering materials for wound healing, known for their high water content and good biocompatibility.

Transanal Resection of a Prolapsed Rectal Lipoma: A Report of a Rare Case.

Lipoma is a benign tumor that arises from mesenchymal cells and is considered relatively rare. Although lipomas can develop anywhere in the digestive tract, they are seldom found within the intestinal tract. Typically asymptomatic, colonic lipomas usually do not require treatment unless they result in symptoms that warrant surgical intervention.

In perennial allergic rhinitis, RQLQ is improved similarly by Azelastine 0.15 and mometasone furoate.

Unlabelled: Some double-blind, placebo-controlled trials have shown that Azelastine (Aze) high dose (0.15%) was effective in seasonal (SAR) and perennial allergic rhinitis (PAR). However, there was no long-term comparison between Aze 0.

Radial Artery Thrombosis and Associated Risk Factors in Patients Undergoing Radial Coronary Angiography.

Radial access is considered the preferred method for coronary angiography (CAG) and percutaneous coronary intervention. Radial artery thrombosis (RAT) stands out as the primary complication associated with trans-radial access. Our objective was to explore the occurrence of RAT and its associated risk factors.

Understanding Diabetic Cardiomyopathy: Insulin Resistance and Beyond.

Diabetic cardiomyopathy (DC) is a syndrome of heart failure occurring in patients with diabetes mellitus (DM), independent of other risk factors. It is a relatively underdiagnosed condition with a prolonged subclinical phase. There is an abundance of studies put forward to explain the underlying pathogenic mechanisms observed in this condition.

Coronary Dissection - Back to the Future - Finding Good in the Bad!

It has been recognized for decades that dissections occur as a mechanism of balloon angioplasty. A successful angioplasty result contains some degree of intimal splitting and disruption, which usually heals well. Nonetheless, some dissections are extensive, leading to serious ischaemic complications.

Protective effect and mechanism of Sufentanil on acute lung injury in septic mice.

This study was designed to investigate the protective effect and mechanism of Sufentanil on acute lung injury in septic mice based on network pharmacology and animal experiments, and to provide new ideas for clinical treatment. To this end, a protein-protein interaction (PPI) network for common targets was first constructed with Swiss Target Prediction Database, GeneCards Database, Draw Venn Diagram Software, STRING 11.5 Database, Cytoscape 3.

Astragaloside IV alleviates GDM via regulating gut microbiota and gut microbiota metabolomic.

Background: Gestational diabetes mellitus (GDM), a severe pregnancy disorder, is a temporary form of diabetes that occurs during gestation. Astragaloside IV (AS IV), a natural and effective composition of , shows pharmacological effects against diabetes. On the contrary, the effects of AS IV on GDM development are still not clear.

Hidden blood loss and risk factors after percutaneous endoscopic transforaminal lumbar interbody fusion.

Purpose: In this study, we aimed to assess the occurrence of hidden blood loss (HBL) and its associated risk factors in patients with lumbar degenerative diseases who underwent percutaneous endoscopic transforaminal lumbar interbody fusion (Endo-TLIF).

Methods: Sex, age, height, weight, body mass index, and medical history including hypertension, diabetes, and osteoporosis were recorded. The duration of symptoms, preoperative lumbar subcutaneous fat tissue thickness (measured using midsagittal T2-weighted magnetic resonance imaging), lumbar disc degeneration grade, and other basic patient information were also documented.

Successful treatment of a chronic myeloid leukemia patient with extreme thrombocytosis by a combination of imatinib and interferon‑α: A case report.

Chronic myeloid leukemia with extreme thrombocytosis (CML-T), defined by a platelet count >1,000x10/l is a rare leukemia subtype. The present case report described a 66-year-old female CML-T patient presenting with a platelet count of 3,798x10/l, but a consistently normal spleen size. Following treatment with imatinib combined with interferon-α, the patient achieved hematological remission within 2 months, with a platelet count reduction to 311x10/l and complete cytogenetic remission after 10 months.

Unveiling a pathogenic gene variant in a Mexican family with Fanconi anemia through next‑generation sequencing.

Fanconi anemia (FA) is the most common hereditary bone marrow failure syndrome, with an incidence of 1 in 5,000,000. This disease is caused by an alteration in one of the 23 genes associated with the FA/BRCA DNA repair pathway, which is responsible for repairing interstrand bridges generated during homologous recombination. FA has been associated with a predisposition to other types of neoplasm.