2 results match your criteria: "Vaccine and Gene Therapy Institute at Oregon Health and Science University[Affiliation]"
Intestinal proteomic analysis of a novel non-human primate model of experimental colitis reveals signatures of mitochondrial and metabolic dysfunction.
Mucosal Immunol
November 2019
Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.
Animal models recapitulating features of chronic colitis, such as ulcerative colitis, Crohn's disease, or HIV infection, are critical to study disease pathogenesis and test novel therapeutics. In this study, we used a proteomics approach to explore the molecular intestinal response in two rhesus macaque (RM) animal models of experimentally induced colitis using dextran sulfate sodium (DSS) and simian immunodeficiency virus (SIV) infection. Proteomic analysis detected more than 2500 proteins in colonic tissue collected from 30 RMs.
View Article and Find Full Text PDFRoles of Non-coding RNAs During Herpesvirus Infection.
Curr Top Microbiol Immunol
June 2019
Vaccine and Gene Therapy Institute at Oregon Health and Science University, Beaverton, OR, USA.
Article Synopsis
- Non-coding RNAs (ncRNAs) are crucial for the life cycles of herpesviruses and help these viruses persist in their hosts for long periods.
- The chapter covers various types of ncRNAs generated by different herpesvirus families during infections and explores how these viruses manipulate cellular ncRNAs.
- It also discusses the overall impact of ncRNAs on the viral life cycle, the host environment, and how they contribute to disease development.