26,746 results match your criteria: "VU University Medical Center & Academic Centre for Dentistry Amsterdam ACTA[Affiliation]"

Article Synopsis
  • - Spinal cord stimulation (SCS) is a minimally invasive method used to treat severe neuropathic pain, but it's important to be aware of possible biologic complications during implantation.
  • - Although biologic complications like infection and nerve injury happen less often than device-related issues, they can have more serious effects on patients.
  • - Understanding these potential complications is essential for doctors to ensure patient safety and improve outcomes when using SCS for pain management.
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Survivors of COVID-19 are susceptible to diminished health-related quality of life (HRQoL) and adverse psychological health, which may be exacerbated by their experiences of fear and the impact of the pandemic itself. This study aims to identify distinct fear and impact patterns related to the COVID-19 pandemic among survivors through latent profile analysis (LPA) and examine the associations of fear and impact patterns with post-traumatic stress symptoms (PTSS) and HRQoL. A total of 5,890 Vietnamese COVID-19 survivors completed the COVID-19 Impact Battery- Disability Scale (CIB-D), the Fear of COVID-19 Scale (FCoV-19 S), the Impact of Event Scale-Revised for PTSS, and the 36-Item Short Form Survey (SF-36) for HRQoL.

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Treatment Patterns of Childhood Glaucoma in the United States: Analysis of IRIS Registry (Intelligent Research in Sight).

Am J Ophthalmol

November 2024

From the Department of Ophthalmology (A.F., D.M.V., K.A., I.Y.C., D.S.F., A.L., A.C.L., J.W.M., P.P., K.S., T.E., N.Z., J.W.M., A.L.), Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

Article Synopsis
  • The study aimed to analyze treatment patterns for childhood glaucoma in the U.S. by examining patient records from 2013 to 2020.
  • It included 3069 patients, revealing that only 16.1% underwent surgery while 93.6% were treated with medications, with specific procedures varying based on the type of glaucoma.
  • Key factors influencing the need for surgeries included having primary congenital glaucoma, higher intraocular pressure, and being younger than one year at diagnosis.
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Importance: Nonresponse to hepatitis B vaccine is common among people with HIV, resulting in vulnerability to infection with hepatitis B virus (HBV).

Objective: To compare the seroprotection response achieved with a 2-dose (noninferiority, 10% margin) and a 3-dose hepatitis B vaccine with a cytosine phosphoguanine adjuvant (HepB-CpG vaccine) vs a conventional 3-dose hepatitis B vaccine with an aluminum hydroxide adjuvant (HepB-alum vaccine) in people with HIV and prior nonresponse to HepB-alum vaccine.

Design, Setting, And Participants: This phase 3, open-label, randomized clinical trial included people with HIV receiving antiretroviral therapy (CD4 cell count ≥100 cells/μL and HIV RNA <1000 copies/mL) without past or present serological evidence of having HBV or a response to hepatitis B vaccine.

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Article Synopsis
  • The study investigates the impact of ethnicity on maternal and perinatal outcomes among low-risk women in a midwife-led care setting, focusing on non-Western versus Dutch women.
  • A cohort of 977 low-risk pregnant women was analyzed, with key outcomes including gestational age, mode of birth, and birthweight, while controlling for various factors like area deprivation and maternal education.
  • Findings revealed that non-Western women had a higher likelihood of specific characteristics such as being multiparous, living in deprived areas, having lower education, and higher BMI, along with more significant challenges in prenatal care and a higher incidence of gestational diabetes compared to their Dutch counterparts.
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Plants continuously respond to changing environmental conditions to prevent damage and maintain optimal performance. To regulate gas exchange with the environment and to control abiotic stress relief, plants have pores in their leaf epidermis, called stomata. Multiple environmental signals affect the opening and closing of these stomata.

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Article Synopsis
  • Post-recanalization target vessel re-occlusion (TVR) is a known complication after endovascular thrombectomy (EVT), linked to poor long-term outcomes, but its causes and incidence right after the procedure are not well understood.
  • A multicenter study examined 167 patients undergoing EVT for large vessel occlusion, measuring changes in the TICI score immediately after the procedure and 10 minutes later, revealing that 16.2% experienced a score change, with 70% of those worsening.
  • The study suggests that neurointerventionalists should conduct angiographic assessments 10 minutes post-EVT to better manage the risk of TVR, considering that only 31% of the entire cohort achieved functional independence at
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Article Synopsis
  • Percutaneous balloon ganglyolysis (PBG) is an effective, low-cost, and minimally invasive treatment for trigeminal neuralgia (TN), with 42.3% of patients experiencing immediate pain resolution.
  • A study analyzed 52 TN patients who underwent 83 PBG procedures, identifying that 30.8% required retreatment after a median of 32 months, with significant predictors for retreatment being TN duration of ≤ 6 months.
  • Findings suggest that understanding TN duration may help inform treatment strategies, highlighting the need for further research to validate these results.
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Background: clinical guidelines recommend initiation of antiviral therapy as soon as possible for patients hospitalized with confirmed or suspected influenza.

Methods: A multicenter US observational sentinel surveillance network prospectively enrolled adults (aged ≥18 years) hospitalized with laboratory-confirmed influenza at 24 hospitals during October 1, 2022-July 21, 2023. A multivariable proportional odds model was used to compare peak pulmonary disease severity (no oxygen support, standard supplemental oxygen, high-flow oxygen/non-invasive ventilation, invasive mechanical ventilation, or death) after the day of hospital admission among patients starting oseltamivir treatment on the day of admission (early) versus those who did not (late or not treated), adjusting for baseline (admission day) severity, age, sex, site, and vaccination status.

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Does enhanced meaning after meaning-centered group psychotherapy mediate a reduction in depressive symptoms in cancer survivors? A mediation analysis in the context of a randomized controlled trial.

Support Care Cancer

November 2024

Department of Clinical, Neuro-, and Developmental Psychology, Cancer Center Amsterdam (CCA), Amsterdam Public Health Research Institute (APH), Vrije Universiteit Amsterdam, Van Der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands.

Purpose: After meaning-centered group psychotherapy for cancer survivors (MCGP-CS), depressive symptoms tend to decrease. An enhanced sense of meaning may play a mediating role in this decrease. The aim of this study was to assess whether personal meaning mediates the relationship between MCGP-CS and depressive symptoms.

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Introduction: Type 1 diabetes (T1D) is a chronic condition marked by insulin deficiency and hyperglycemia, with an increasing global incidence, particularly among children. Despite improvements in diabetes management, individuals with T1D continue to experience higher rates of cardiovascular disease (CVD), the leading cause of mortality in this population. Traditional CVD risk factors such as dyslipidemia and poor glycemic control are insufficient to fully explain the elevated risk in T1D, prompting further investigation into additional factors.

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Neurostimulation for the Treatment of Cancer-Induced Pain: A Scoping Review.

Neuromodulation

February 2025

Department of Pain Medicine, Division of Anesthesiology, Critical Care & Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.

Objectives: Cancer pain is among the most prevalent and challenging symptoms in cancer care, with up to 95% of patients with late-stage cancer experiencing moderate-to-severe pain. Conventional pharmacologic treatments, including opioids, carry risks, and patients' conditions may be refractory to medical management or have contraindications. Neurostimulation techniques, such as spinal cord stimulation (SCS), dorsal root ganglion stimulation (DRGS), and peripheral nerve stimulation (PNS), have shown promise in treating treatment-induced cancer pain.

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Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome in Vietnamese Patients.

Medicina (Kaunas)

November 2024

Center of Endocrinology, Metabolism, Genetic/Genomics and Molecular Therapy, Vietnam National Children's Hospital, 18/879 La Thanh, Dong Da, Hanoi 11512, Vietnam.

: Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHH; OMIM 238970) is one of the rare urea cycle disorders. Ornithine carrier 1 deficiency causes HHH syndrome, characterized by failure of mitochondrial ornithine uptake, hyperammonemia, and accumulation of ornithine and lysine in the cytoplasm. The initial presentation and time of diagnosis in HHH highly varies.

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Oxidative stress induced by glutamate is a significant contributor to neuronal cell damage and can lead to neurodegenerative diseases such as Alzheimer's, Huntington's, and ischemic brain injury. At the cellular level, oxidative stress increases Ca ion influx and reactive oxygen species (ROS), which activate the MAPK signaling pathway. Additionally, the generation of ROS causes mitochondrial dysfunction, triggering apoptosis by promoting the translocation of AIF to the nucleus from the mitochondria.

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Objective: Motor competence development from early to middle childhood is accompanied by great variance. This course can be influenced by many factors in the ecosystem. The objective of this study was to examine which individual characteristics are associated with motor competence development during the transition from early to middle childhood.

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The Behaviour observation scale for Psychomotor Therapy for elderly people with dementia (BPMT-dem) was developed to (1) evaluate the cognitive, emotional and social functioning of people with dementia in psychomotor therapy, and (2) to facilitate the interdisciplinary communication in treatment of behavioural and mood disruptions. The objective was to investigate the homogeneity and reliability of the BPMT-dem73. The Mokken scaling procedure was used on items and 10 a-priori determined subscales in a sample of 105 people with dementia or severe cognitive impairments.

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Article Synopsis
  • The first Clinical and Scientific Conference on ADSS1 myopathy took place on June 3, 2024, at NIH in Maryland, focusing on this rare inherited neuromuscular disease.
  • The conference highlighted geographical patient clusters from South Korea, Japan, India, and the USA, along with research on pre-clinical models to better understand the disease.
  • Experts identified biochemical pathways for potential therapies and created an ADSS1 myopathy consortium to guide new treatment development.
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Understanding Parental Decision-Making and Determinants of COVID-19 Vaccination for Children in Vietnam: A Cross-Sectional Online Survey.

Vaccines (Basel)

November 2024

National Centre for Epidemiology and Population Health, College of Health and Medicine, Australian National University, Canberra, ACT 2601, Australia.

Background/objectives: In Vietnam, COVID-19 vaccination campaigns for children have encountered numerous challenges due to acceptance issues among parents. This study aimed to assess parental decision-making and identify factors influencing their decision to vaccinate their children against COVID-19.

Methods: This was a cross-sectional online survey conducted between April and May 2023 among parents of children aged 6-17 years enrolled in urban and rural schools in Thai Nguyen province, Vietnam.

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Lateral Flow Assay for Preeclampsia Screening Using DNA Hairpins and Surface-Enhanced Raman-Active Nanoprobes Targeting hsa-miR-17-5p.

Biosensors (Basel)

November 2024

Department of Biomedical Engineering, Texas A&M University, 5045 Emerging Technologies Building, College Station, TX 77843, USA.

Article Synopsis
  • - Preeclampsia (PE) is a serious pregnancy complication that often goes unnoticed until later trimesters, leading to risks for mothers and babies, especially in low- and middle-income countries where healthcare resources are limited.
  • - Recent research identifies variations in hsa-miR-17-5p levels as a potential early marker to differentiate between women with and without PE during the first trimester, indicating the need for early screening.
  • - A new lateral-flow assay (LFA) has been developed to measure hsa-miR-17-5p levels with high specificity and sensitivity using advanced detection methods, aiming to improve early detection and accessibility of testing worldwide.
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Estimated Brain Age in Healthy Aging and Across Multiple Neurological Disorders.

J Magn Reson Imaging

November 2024

Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Article Synopsis
  • - The study investigates how brain aging differs between healthy controls and patients with various neurological disorders, focusing on its clinical implications and using a retrospective analysis of MRI data.
  • - A total of 2,913 healthy individuals and 1,600 patients with conditions like multiple sclerosis and Alzheimer's were assessed by comparing their estimated brain age using advanced imaging techniques.
  • - Results showed that individuals with "accelerated" brain age tended to have higher white matter hyperintensities and lower brain volumes, with notable correlations between increased brain age gap and cognitive decline across all disorders examined.
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Computerized decision support to optimally funnel patients through the diagnostic pathway for dementia.

Alzheimers Res Ther

November 2024

Alzheimer Center Amsterdam and Department of Neurology, VU University Medical Center, Amsterdam UMC, De Boelelaan 1118, Amsterdam, 1081 HZ, The Netherlands.

Background: The increasing prevalence of dementia and the introduction of disease-modifying therapies (DMTs) highlight the need for efficient diagnostic pathways in memory clinics. We present a data-driven approach to efficiently guide stepwise diagnostic testing for three clinical scenarios: 1) syndrome diagnosis, 2) etiological diagnosis, and 3) eligibility for DMT.

Methods: We used data from two memory clinic cohorts (ADC, PredictND), including 504 patients with dementia (302 Alzheimer's disease, 107 frontotemporal dementia, 35 vascular dementia, 60 dementia with Lewy bodies), 191 patients with mild cognitive impairment, and 188 cognitively normal controls (CN).

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Aim: To determine the rate of prediabetes among and the pre-transplant plasma high-sensitivity C-reactive protein (hs-CRP) value predictive of prediabetes in patients during their first year post-living donor kidney transplant.

Methods: A total of 538 patients underwent living donor kidney transplantation between January 2018 and December 2020, 413 of whom met the inclusion criteria for this study. All patients underwent oral glucose tolerance tests (OGTTs) with 75 g glucose/200 mL solution, starting 3 months post-transplant and repeating the test every 3 months for the first year.

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