43,931 results match your criteria: "VT; Geisel School of Medicine at Dartmouth[Affiliation]"
Infect Dis (Lond)
December 2024
Department of Science and Environment, PandemiX Center, Roskilde University, Roskilde, Denmark.
Background: Invasive pneumococcal disease (IPD) remains a significant public health concern, particularly in vulnerable populations such as the elderly. This study focuses on the Faroe Islands, a unique setting for monitoring pneumococcal disease trends due to its high vaccination coverage and geographic isolation.
Objective: To examine the prevalence, trends and serotype distribution of IPD in the Faroe Islands from 2000 to 2023, focusing on the impact of pneumococcal conjugate vaccines (PCVs) on disease incidence and serotype replacement.
Ultrason Sonochem
December 2024
School of Energy and Power Engineering, Xi'an Jiaotong University, Xi'an 710049, China; MOE Key Laboratory of Cryogenic Technology and Equipment, Xi'an Jiaotong University, Xi'an 710049, China.
Cavitation plays a crucial role in the reliability of components in refrigeration systems. The properties of refrigerants change significantly with temperature, thereby amplifying the impact of thermodynamic effects. This study, based on the Large Eddy Simulation (LES) method and the Schnerr-Sauer (S-S) cavitation model, investigates the transient cavitating flow characteristics of the R134a refrigerant in a Venturi tube (VT).
View Article and Find Full Text PDFEur J Cancer
December 2024
Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Cardio-Oncology Program, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Background: Immune checkpoint inhibitors (ICIs) are associated with an increased risk of major adverse cardiovascular events (MACE). Glucagon-like peptide-1 agonists (GLP1a), initially developed for type 2 diabetes mellitus (T2DM), have shown promising results in reducing cardiovascular events. We aimed to investigate the effect of GLP1a on cardiovascular events in patients receiving ICIs.
View Article and Find Full Text PDFEur J Appl Physiol
December 2024
Sports Performance Research Institute New Zealand, Auckland University of Technology, Auckland, New Zealand.
Purpose: To determine the effect of carbohydrate ingestion during prolonged exercise on durability of the moderate-to-heavy-intensity transition and severe-intensity performance.
Methods: Twelve trained cyclists and triathletes (10 males, 2 females; peak, 59 ± 5 mL kg min; training volume, 14 ± 5 h week) performed an incremental test and 5-min time trial (TT) without prior exercise (PRE), and after 150 min of moderate-intensity cycling, with (POST) and without (POST) carbohydrate ingestion.
Results: Power output at the first ventilatory threshold (VT) was lower in POST (225 ± 36 W, ∆ -3 ± 2%, P = 0.
J Pain Symptom Manage
December 2024
Larner College of Medicine at the University of Vermont, Burlington, VT, USA.
Context: Medical education is moving towards competency based medical education (CBME). This provides opportunities and challenges for the field of Hospice and Palliative Medicine (HPM). The American Academy of Hospice and Palliative Medicine (AAHPM) created the Assessment Workgroup to spearhead a shared vision and process to implement high-quality assessment of fellow performance.
View Article and Find Full Text PDFLancet Infect Dis
December 2024
MMV Medicines for Malaria Venture, Geneva, Switzerland.
Background: Novel antimalarials are needed to address emerging resistance to artemisinin and partner drugs. We did two trials to evaluate safety, tolerability, pharmacokinetics, and activity against blood stage Plasmodium falciparum for the drug candidate MMV533.
Methods: A phase 1a first-in-human (FIH) trial was conducted at Nucleus Network (Melbourne, VIC, Australia).
Commun Med (Lond)
December 2024
Association of American Medical Colleges, Washington, DC, USA.
There has been considerable discussion of how best to address racial and ethnic disparities in health outcomes, both globally and specifically in the United States. Increasing diversity among future clinicians and physician-scientists has been identified as a key strategy for addressing and correcting health disparities among underrepresented populations. Increasingly, medical schools, the institutions that train clinicians, have embraced the practice of holistic review for evaluating applicants and virtually all medical schools have reported contributing to a diverse physician workforce as an important aspect of their educational mission.
View Article and Find Full Text PDFInt J Pediatr Otorhinolaryngol
December 2024
Hacettepe University Department of Otorhinolaryngology, Ankara, Turkey. Electronic address:
Objective: We aimed to evaluate the clinical findings of our cochlear implant (CI) patients with otitis media with effusion (OME) and CI patients treated with ventilation tube (VT) for OME.
Methods: The medical records of patients who underwent CI surgery at Hacettepe University, Department of Otorhinolaryngology, between November 1997 and March 2023 were reviewed. Patients who had OME or VT in the implanted ear at the time of surgery were included in the study.
Discov Oncol
December 2024
Department of Biological Sciences, Faculty of Science, King Abdulaziz University, 80203, Jeddah, Saudi Arabia.
Prostate cancer is a prevalent and highly heterogeneous malignancy that affects men globally. Despite the availability of various treatment targets, Cytochrome P450 (CYP) enzymes have gained significant attention due to their crucial role in metabolizing both endogenous and exogenous compounds. This study explores Diosmetin as a potential CYP antagonist for treating prostate cancer.
View Article and Find Full Text PDFJ Am Chem Soc
December 2024
Faculty of Chemistry, University of Łódź, Tamka 12, 91403 Łódź, Poland.
Cofacial arrangement of two Blatter radicals enforced by the -naphthalene scaffold represents a new approach to stable diradicals with strong through-space interactions. Two stereoisomers of the naphthalene-diradicals, and , are investigated by XRD, VT-EPR, UV-vis, electrochemical, kinetic, and DFT methods. In solutions, both stereoisomers exist as open-shell singlets with Δ = -3.
View Article and Find Full Text PDFJ Nurs Adm
January 2025
Author Affiliations: Assistant Clinical Professor and Program Director (Dr Connor), Assistant Director, Clinical Core (Dr Dufour), and Assistant Director, Community Core (Dr Zadvinskis), Helene Fuld Health Trust National Institute for Evidence-Based Practice in Nursing & Healthcare, The Ohio State University College of Nursing, Columbus; Director of Government Affairs and Educational Programs (Dr Waddell), Organization of Nurse Leaders MA, RI, CT, NH, VT, Boston, Massachusetts; Director of Professional Development and Nurse Scientist (Dr Powell), AtlantiCare Regional Medical Center, Atlantic City, New Jersey; Senior Vice President and Chief Nurse Executive (Dr Gorsuch), Summa Health, Akron; and Assistant Professor of Clinical Practice (Doctoral), The Ohio State University College of Nursing, Columbus; Associate Professor Research & Education Librarian, Nursing Liaison, Affiliate Faculty (Brown), Virginia Commonwealth University School of Nursing, VCU Libraries, Health Sciences Library, Richmond; and Vice President for Health Promotion, University Chief Wellness Officer, Dean and Helene Fuld Health Trust Professor of Evidence-Based Practice (Dr Melnyk), College of Nursing, and Professor of Pediatrics & Psychiatry, College of Medicine, Executive Director, the Helene Fuld Health Trust National Institute for Evidence-Based Practice; and Chief Operating Officer and Clinical Core Director (Dr Gallagher-Ford), Helene Fuld Health Trust National Institute for Evidence-Based Practice in Nursing & Healthcare, The Ohio State University, College of Nursing, Columbus.
Objective: This scoping review describes findings from published literature, evaluates the association between hospital accreditation or certification and patient outcomes, and identifies gaps.
Background: Healthcare accreditation and certification organizations set standards and evaluate whether the standards are met. Despite the extensive efforts of both parties to improve healthcare delivery, poor patient health outcomes still exist in the United States.
Circ Arrhythm Electrophysiol
December 2024
Heart and Lung Center (P.P., J.L., D.V., H.M., P.S., H.-K.N., M.K.).
Background: Cardiac sarcoidosis involves a significant but difficult-to-define risk of sudden cardiac death (SCD). Current guidelines recommend consideration of an implantable cardioverter defibrillator for patients with extensive or significant myocardial late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging. However, extensive/significant LGE is not defined.
View Article and Find Full Text PDFLancet Digit Health
December 2024
University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, UK; Centre for Patient Reported Outcomes Research, School of Health Sciences, College of Medical and Dental Sciences, Birmingham, UK; University of Birmingham, Birmingham, UK. Electronic address:
Without careful dissection of the ways in which biases can be encoded into artificial intelligence (AI) health technologies, there is a risk of perpetuating existing health inequalities at scale. One major source of bias is the data that underpins such technologies. The STANDING Together recommendations aim to encourage transparency regarding limitations of health datasets and proactive evaluation of their effect across population groups.
View Article and Find Full Text PDFJ Affect Disord
December 2024
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK. Electronic address:
Background: Early diagnosis and treatment of mental illnesses is hampered by the lack of reliable markers. This study used machine learning models to uncover diagnostic and risk prediction markers for eating disorders (EDs), major depressive disorder (MDD), and alcohol use disorder (AUD).
Methods: Case-control samples (aged 18-25 years), including participants with Anorexia Nervosa (AN), Bulimia Nervosa (BN), MDD, AUD, and matched controls, were used for diagnostic classification.
Adv Drug Deliv Rev
December 2024
Department of Biological Systems Engineering, Virginia Tech, 1230 Washington Street, Blacksburg 24061, USA; Macromolecular Innovation Institute, Virginia Tech, 240 W Campus Dr, Blacksburg 24060, USA. Electronic address:
In recent years, the field of 3D bioprinting has witnessed the intriguing development of a new type of bioink known as microbial inks. Bioinks, typically associated with mammalian cells, have been reimagined to involve microbes, enabling many new applications beyond tissue engineering and regenerative medicine. This review presents the latest advancements in microbial inks, including their definition, types, composition, salient characteristics, and biomedical applications.
View Article and Find Full Text PDFCan J Cardiol
December 2024
Department of Medicine, University of Toronto, Toronto, Canada; Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, Toronto, Canada. Electronic address:
Patients on veno-arterial extracorporeal membrane oxygenation (VA-ECMO) are at high risk for ventricular arrhythmias due to derangements in myocardial perfusion, hemodynamics, and heightened catecholamine states. Existing data on the management and outcomes of patients with electrical storm or refractory ventricular tachycardia/fibrillation (VT/VF) treated with VA-ECMO are primarily derived from retrospective observational studies. Typical survival rates are in the range of 40-50%, with 15-20% of patients undergoing VT ablation and 30-40% of patients requiring advanced heart failure therapies (cardiac transplant or durable left ventricular assist device).
View Article and Find Full Text PDFCommunity Ment Health J
December 2024
University of Vermont Larner College of Medicine, Burlington, VT, 05405, USA.
Med Phys
December 2024
Department of Physics, The Verspeeten Family Cancer Centre, London, Ontario, Canada.
Background: Stereotactic arrythmia radioablation (STAR) is a noninvasive technique to treat ventricular tachycardia (VT). Management of cardiorespiratory motion plays an essential role in VT-STAR treatments to improve treatment outcomes by reducing positional uncertainties and increasing dose conformality. Use of an electrocardiogram (ECG) signal, acquired in real-time, as a surrogate to gate the beam has the potential to fulfil that intent.
View Article and Find Full Text PDFERJ Open Res
November 2024
Ludwig Boltzmann Institute for Lung Health, Vienna, Austria.
Background: Oscillometry devices allow quantification of respiratory function at tidal breathing but device-specific reference equations are scarce: the present study aims to create sex-specific oscillometric reference values for children and adolescents using the Resmon PRO FULL device.
Methods: Healthy participants (n=981) aged 6 to 17 years of the Austrian LEAD general population cohort were included. Subjects had normal weight (body mass index ≤99th percentile) and normal lung volumes (total lung capacity (TLC) ≥ lower limit of normal).
Front Clin Diabetes Healthc
December 2024
Medical Affairs, Digicare Health Solutions Private Limited, Ahmedabad, India.
Background: The integration of digital health applications into type 2 diabetes mellitus (T2DM) management presents promising opportunities for optimizing glycemic control, enhancing adherence, and improving health outcomes. MyTatva's Glycemic Lifestyle Intervention in Diabetes Empowerment (GLIDE) program, which integrates dietary and exercise regimens, cognitive behavioral therapy (CBT), and Internet of Things (IoT) devices, potentiates this approach. This study aimed to evaluate the effectiveness of the GLIDE program's personalized, comprehensive approach in improving glycemic control over 90 days among T2DM patients.
View Article and Find Full Text PDFTransl Cancer Res
November 2024
Section of Urologic Oncology, Rutgers Cancer Institute, New Brunswick, NJ, USA.
Background And Objective: A standard of care for muscle-invasive bladder cancer (MIBC) is cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC). Given recent improvements in NAC and the morbidity associated with RC, bladder-sparing therapy has been investigated as a promising treatment for patients with MIBC who experience a complete clinical response (CCR) to systemic therapy. However, clinical staging is unreliable, making it challenging to determine ideal candidates for bladder-sparing therapy.
View Article and Find Full Text PDFFront Microbiol
November 2024
Department of Animal Science, University of Nebraska-Lincoln, Lincoln, NE, United States.
Introduction: The full extent of interactions between human immunodeficiency virus (HIV) infection, injection drug use, and the human microbiome is unclear. In this study, we examined the microbiomes of HIV-positive and HIV-negative individuals, both drug-injecting and non-injecting, to identify bacterial community changes in response to HIV and drug use. We utilized a well-established cohort of people who inject drugs in Puerto Rico, a region with historically high levels of injection drug use and an HIV incidence rate disproportionately associated with drug use.
View Article and Find Full Text PDFJ Mol Cell Cardiol Plus
December 2024
Key Laboratory of Medical Electrophysiology of the Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan 646000, China.
Unlabelled: Abnormal regional variations in electrical and calcium homeostasis properties have been implicated in catecholaminergic polymorphic ventricular tachycardias (CPVT) attributable to abnormal RyR2-mediated store Ca release, but their underlying mechanism have not been well explored in intact hearts.
Methods: We performed in vivo and ex vivo studies including high throughput mapping of Ca transients (CaT) and transmembrane voltage (V) in murine wild-type (WT) and heterozygous -R2474S/+ hearts, before and during isoprenaline (ISO) challenge.
Results: ISO-challenged -R2474S/+ showed increased incidence of arrhythmia accompanied by abnormal Ca transients compared to WT.
Catheter Cardiovasc Interv
December 2024
Leon H. Charney Division of Cardiology, New York University Langone Health, New York, New York, USA.
Ventricular arrhythmias (VA) are a major cause of morbidity and mortality in patients with coronary artery disease (CAD). Current guidelines recommend revascularization of significant CAD to improve survival in patients with ventricular fibrillation (VF), polymorphic ventricular tachycardia (VT), or those who are post-cardiac arrest. However, revascularization is not recommended for CAD patients with suspected scar-mediated monomorphic VT.
View Article and Find Full Text PDFTrials
December 2024
Division of Cardiothoracic Surgery, Washington University in St. Louis, St. Louis, MO, USA.
Background: The American College of Cardiology, American Heart Association, and Centers for Medicare and Medicaid Services recommend shared decision-making (SDM) for patients with severe aortic stenosis choosing between transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR). Although tools such as patient decision aids (DAs) and training in SDM have been shown to improve SDM, implementation of SDM and DAs is limited. The IMproving treatment decisions for Patients with AortiC stenosis Through Shared Decision Making (IMPACT SDM) study aims to (1) determine the effectiveness of the interventions (a DA and clinician SDM training) in achieving SDM (primary outcome) and improving the quality of decisions about aortic valve replacement, (2) determine the reach of the DAs and adoption of training, and (3) explore potential mechanisms of effectiveness and implementation at the patient-, clinician-, and clinic-level.
View Article and Find Full Text PDF