A new furanochromone from the leaves of .

Phytochemical study on the EtOAc-soluble extract of the leaves of led to the isolation of a new furanochromone, 6,8-dihydroxy-2-methyl-9-furo[3,2-]chromen-9-one (), along with four known compounds (-). Their structures were elucidated based on the basis of the spectral interpretation. The plausible biosynthesis pathway for the formation of the new furanochromone was proposed.

A computational study of thiol-containing cysteine amino acid binding to Au and Au gold clusters.

Density functional theory (DFT) calculations are employed to examine the adsorption behaviors of cysteine on the gold surface using Au and Au species as model reactants. Computed results show that cysteine molecules prefer to bind with gold clusters via the S-atom of the thiol group in vacuum and thiolate group in water. The gas-phase adsorption energies are around 20.

Allogeneic umbilical cord-derived mesenchymal stem cell transplantation for treating chronic obstructive pulmonary disease: a pilot clinical study.

Introduction: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. COPD results from chronic inflammation of the lungs. Current treatments, including physical and chemical therapies, provide limited results.

Structural and functional characteristics of clustered amylopectin produced by glycogen branching enzymes having different branching properties.

Three bacterial glycogen branching enzymes (GBEs) having different branching characteristics were used to produce clustered amylopectin (CAP), and structure and functional properties of CAPs were intensively analyzed. Branch distributions of three CAPs varied from very short (DP = 6.65) to medium (DP = 14.

Two new meroterpenoids from the aerial parts of (Vitaceae).

From EtOAc-soluble fraction of the aerial parts of (Vitaceae), two new meroterpenoids named ampechromonol A () and ampechromonol B (), together with five known compounds (-), were isolated. Their structures were elucidated based on NMR spectroscopic analysis. The plausible biosynthesis pathway for the formation of two new meroterpenoids was proposed.

Calculating equivalent dose received from a patient undergoing nuclear medicine procedure by merge phantoms tool and GAMOS/Geant4 6.0.0 software.

Purpose: This report introduces a tool for merging two voxel phantoms to calculate the deposited dose that a person receives from a patient undergoing Nuclear medicine procedures.

Materials And Methods: The phantoms must be converted to the text format used by GEANT4 to treat DICOM images via the GAMOS utilities. The Merge Phantoms Tool can merge two phantoms in two different cases: standing either side by side or opposite.

A new phenolic acid from the wood of .

From the methanol extract of the wood of (Anacardiaceae), we had isolated a new secondary metabolite named gedebic acid () and six known compounds (). Their chemical structures were determined by spectroscopic methods as well as comparing with data in the literature. All compounds were tested for -glucosidase inhibitory activity.

Using the IPTG-Inducible Pgrac212 Promoter for Overexpression of Human Rhinovirus 3C Protease Fusions in the Cytoplasm of Bacillus subtilis Cells.

Expression and secretion of recombinant proteins in the endotoxin-free bacterium, Bacillus subtilis, has been thoroughly studied, but overexpression in the cytoplasm has been limited to only a few proteins. Here, we used the robust IPTG-inducible promoter, Pgrac212, to overexpress human rhinovirus 3C protease (HRV3C) in the cytoplasm of B. subtilis cells.

A new lignan from the flowers of L. (Malvaceae).

From MeOH-soluble fraction of the flowers of (Malvaceae), one new lignan, (+)-4--methyl-5'-methoxy-secoisolariciresinol (), together with four known compounds (-) were isolated. The structures were elucidated based on NMR spectroscopic analysis. The absolute configuration of was determined based on the Cotton effects in the CD spectrum.

Robustness evaluation of Intensity Modulated Proton Therapy plans using Dose Volume Population Histogram.

Purpose: Under geometrical uncertainties, different plan evaluation methods have been suggested but the dose distribution at a specified confidence level being highly desirable is lacking. In this work, we used the DVPH (Dose Volume Population Histogram) tool to evaluate the dose distribution of CTVs and OARs (Organs at Risk) and validate the PTV concept at a certain confidence level.

Methods: The plans were evaluated using PTV DVH and the DVPH approach.

Insight into the adsorption mechanisms of methylene blue and chromium(iii) from aqueous solution onto pomelo fruit peel.

In this study, the biosorption mechanisms of methylene blue (MB) and Cr(iii) onto pomelo peel collected from our local fruits are investigated by combining experimental analysis with simulations. Factors that affect the adsorption such as pH, adsorption time, adsorbent dosage and initial adsorbate concentration, are fully considered. Five isotherm models-Langmuir, Freundlich, Sips, Temkin, and Dubinin-Radushkevich-are employed to estimate the capacity of pomelo peel adsorption, whereas four kinetic models-pseudo-first-order, pseudo-second-order, Elovich and intra-diffusion models-are also used to investigate the mechanisms of the uptake of MB and Cr(iii) onto the pomelo fruit peel.

Large-Scale Coarse-to-Fine Object Retrieval Ontology and Deep Local Multitask Learning.

Object retrieval plays an increasingly important role in video surveillance, digital marketing, e-commerce, etc. It is facing challenges such as large-scale datasets, imbalanced data, viewpoint, cluster background, and fine-grained details (attributes). This paper has proposed a model to integrate object ontology, a local multitask deep neural network (local MDNN), and an imbalanced data solver to take advantages and overcome the shortcomings of deep learning network models to improve the performance of the large-scale object retrieval system from the coarse-grained level (categories) to the fine-grained level (attributes).

G37V mutation of Aβ42 induces a nontoxic ellipse-like aggregate: An in vitro and in silico study.

The glycine zipper motif at the C-terminus of the β-amyloid (Aβ) peptide have been shown to strongly influence the formation of neurotoxic aggregates. A previous study showed that the G37L mutation dramatically reduces the Aβ toxicity in vivo and in vitro. However, the primary cause and mechanism of the glycine zipper motif on Aβ properties remain unknown.

A new cardenolide glycoside from the roots of (lour.) merr. (Asclepiadaceae).

From remaining aqueous fraction of the roots of , one new cardiac glycoside named periplogenin 3---gentiobioside () together with six known ones () were isolated. Their relative structures were elucidated based on NMR spectroscopic analysis. Compound showed moderate cytotoxicity against non-small cell lung carcinoma NCI-H460 and ovarian cancer HeLa cells.

Presence of Hypertrophic Cardiomyopathy Related Gene Mutations and Clinical Manifestations in Vietnamese Patients With Hypertrophic Cardiomyopathy.

Background: Hypertrophic cardiomyopathy (HCM) is associated primarily with pathogenic mutations in sarcomeric genes. The aim of this study was to identify the prevalence and distribution of disease-causing mutations in HCM-associated genes and the genotype-phenotype relationship in Vietnamese patients with HCM.

Methods and results: Genetic testing was performed by next-generation sequencing in 104 unrelated probands for 23 HCM-related genes and in 57 family members for the mutation(s) detected.

Semi-empirical method for determining the density of liquids using a NaI(Tl) scintillation detector.

In this study, we developed a new method for determining the density of liquids using the Compton backscattering technique. The principle of this method is based on the change in the area under a single scattering peak versus the liquid density. The linear calibration curve of the ratio R versus the density is required to determine the density of an unknown liquid (R is the ratio of the area under a single scattering peak for a liquid relative to that for water).

Erythromycin, Cethromycin and Solithromycin display similar binding affinities to the E. coli's ribosome: A molecular simulation study.

Macrolide antibiotics bind to the exit tunnel of the ribosome and inhibit protein synthesis blocking its translocation. Thus, antibiotics including the known macrolide Erythromycin (ERY) are active against bacteria. However, at present, some bacteria show resistance to drugs, which requires the development of new powerful antibacterial agents.

A plastid phylogeny of the Old World fern genus Leptochilus (Polypodiaceae): Implications for cryptic speciation and progressive colonization from lower to higher latitudes.

The newly defined fern genus Leptochilus contains about 50 species occurring in subtropical to tropical Asia and adjacent Pacific islands. The circumscription and phylogeny of the genus have been ambiguous and its species had been included in various genera such as Colysis, Dendroglossa, Kontumia, Microsorum, and Paraleptochilus. Previous molecular studies sampled only 2-4 molecular markers and 2-16 accessions of Leptochilus.

Dosimetric and Monte Carlo verification of jaws-only IMRT plans calculated by the Collapsed Cone Convolution algorithm for head and neck cancers.

Aim: The aim of this study is to verify the Prowess Panther jaws-only intensity modulated radiation therapy (JO-IMRT) treatment planning (TP) by comparing the TP dose distributions for head-and-neck (H&N) cancer with the ones simulated by Monte Carlo (MC).

Background: To date, dose distributions planned using JO-IMRT for H&N patients were found superior to the corresponding three-dimensional conformal radiotherapy (3D-CRT) plans. Dosimetry of the JO-IMRT plans were also experimentally verified using an ionization chamber, MapCHECK 2, and Octavius 4D and good agreements were shown.

Modelling the mitigation speeds of Cs, Sr and I in the topsoils and assessment of the radiological hazards.

Fate modelling of artificial radionuclides (ARs) in top soils are necessary to assess the radiological effects to population. Among ARs, Cs, Sr and I are very important since the large abundances in the environment. In this study, the fates of Cs, Sr and I in the surface soil layers were simulated by the soil model which was developed by the Canadian Centre for Environmental Modelling and Chemistry (CEMC).

A new dimeric alkylresorcinol from the stem barks of (Anacardiaceae).

From an EtOAc-soluble fraction of the stem barks of (Anacardiaceae), one new dimeric alkylresorcinol named integracin E (), together with 4 known compounds (-) were isolated. Their chemical structures were elucidated based on the spectroscopic data interpretation. The absolute configuration of was determined by the specific rotation analysis of its acid-catalyzed hydrolysis product.

Characterization of Senescence of Human Adipose-Derived Stem Cells After Long-Term Expansion.

Introduction: Since the 1980s, adipose-derived stem cells (ASCs) have become a powerful and potential source for stem cell-based therapy, regenerative medicine, and even drug delivery in cancer treatment. The development of off-the-shelf mesenchymal stem cells (MSCs), including ASCs, has rapidly advanced in recent years with several clinical trials and approved products. In this technology, ASCs should be expanded long term in order to harvest higher cell number.

Soil radon gas in some soil types in the rainy season in Ho Chi Minh City, Vietnam.

Field experiments on soil radon and radium concentrations were carried out in eighteen locations in Ho Chi Minh City, Vietnam. Soil radon depth profiles (10-100 cm) of loam, sand and clay soil samples in the rainy season were measured using RAD7 radon detector. Mean concentrations of Rn and Ra were found to be 28.

Nimbandiolactone-21 and nimbandioloxyfuran, two new 28-norlimonoids from the leaves of (Meliaceae).

From an EtOAc-soluble fraction of the leaves of , two new 28-norlimonoids named nimbandiolactone-21 () and nimbandioloxyfuran (), together with nimbandiolactone-23 (), were isolated. Their relative structures were elucidated based on NMR spectroscopic interpretation and biosynthetic consideration. Nimbandioloxyfuran () and nimbandiolactone-23 () showed potent -glucosidase inhibitory activity, with the IC values of 46.