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Prevalence and prognostic value of autonomic neuropathy assessed by Sudoscan® in transthyretin wild-type cardiac amyloidosis.

ESC Heart Fail

April 2021

Cardiology Department, AP-HP (Assistance Publique-Hôpitaux de Paris), Henri Mondor University Hospital, 51 Avenue du Marechal de Lattre de Tassigny, Créteil, F-94010, France.

Article Synopsis
  • The study investigated the prevalence of autonomic neuropathy (AN) in patients with transthyretin wild-type cardiac amyloidosis (ATTRwt-CA) using a device called Sudoscan® that measures skin conductance in hands and feet.
  • Results showed that nearly 50% of ATTRwt-CA patients had reduced skin conductance, indicating a significant prevalence of AN compared to healthy elderly controls.
  • The findings suggest that low skin conductance values are linked to a worse prognosis, making Sudoscan® a useful tool for screening patients at higher risk for complications.
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Background: Sudomotor dysfunction is one of the earliest pathophysiologic abnormalities in diabetes. Sudoscan™ (Impeto Medical, Paris, France) was developed as a noninvasive, rapid, and quantitative assessment of sudomotor function and has been shown to be sensitive in the detection of neuropathy. This global collaborative analysis aimed to establish reference values in healthy subjects of different ethnic groups, age, and gender, to define factors potentially affecting results, and to provide standardization of the methodology.

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