Salicylidene-based dual-responsive 'turn on' fluorometric chemosensors for the selective detection of Zn, Al and F ions: theoretical investigation and applications in the live cell imaging of zebrafish larvae and molecular logic gate operation.

Four salicylidene-based dual-responsive chemosensors 1,5-bis(5-bromosalicylaldehyde)carbohydrazone (R1), 1,5-bis(5-bromosalicylaldehyde)thiocarbohydrazone (R2), 1,5-bis(3-ethoxysalicylaldehyde)carbohydrazone (R3) and 1,5-bis(3-ethoxysalicylaldehyde)thiocarbohydrazone (R4) were synthesized and characterized. The molecular structures of R1 and R3 were confirmed by single crystal X-ray diffraction technique, which crystallized in the orthorhombic and monoclinic 2/ space groups, respectively. The chemosensor molecules were investigated for their recognition properties against the selected cations (K, Ca, Mn, Co, Ni, Cu, Zn, Fe and Al) and anions (F, Cl, Br, I, HSO, HPO, ClO, N and NO) by colorimetry, absorption spectroscopy, fluorescence spectroscopy, H NMR spectroscopy and theoretical studies.

Theoretical and experimental investigation of mixed-ligand metal(II) Schiff base complexes using maleic acid as the auxiliary ligand.

This work is focused on the synthesis of several transition metal complexes [ML(MA)], where M = Copper (II), Zinc (II), Cobalt (II) and Nickel (II), MA = maleic acid and L = Schiff base generated from benzene-1,2-diamine [phenylenediamine] and 4-chlorobenzaldehyde. The characterization using Fourier-Transform Infrared, Nuclear Magnetic Resonance spectroscopy, Ultraviolet-Visible spectra, Mass, Electro Paramagnetic Resonance and elemental analysis confirm the square planar geometry of the complexes. The antimicrobial potential of the complexes has been tested by the broth dilution method and the antioxidant method has been done by free radical scavenging analysis.

Theoretical screening and electrochemical sensor for determination of norepinephrine using a molecularly imprinted poly (3-amiophenylboronic acid).

Norepinephrine (NE) is the primary catecholamine (CA) of interest in the medical field, as it plays a key role in regulating the hormonal and neurological systems. Some NE concentration dysfunction can lead to a number of serious physical conditions. As a result, quick and sensitive NE detection is most critical in medical technology.

Pharmaceutical manifestation of Knoevenagel condensed metal (II) complexes through virtual, and assessments.

Sulphur containing compounds possess a great deal of interest due to wide range of beneficial activities towards biotic species. This work also deals with the study of biological examination of newly synthesized sulphur containing Cu(II) and Zn(II) complexes derived from (E)-4-(phenylimino)-3-((E)-1-(phenylimino)ethyl)pent-2-ene-1-thiol Schiff bases. Moreover, the DNA nuclease efficiency of the synthesized metal complexes is studied by UV absorption studies, Fluorescence studies, Viscosity and CV titrations which confirm the intercalative mode of binding.

Sustainable architecting of CoSnO/CE-BN-based electrochemical platform for highly selective and ultrasensitive detection of 2-nitroaniline in life samples.

A novel binary heterogeneous electrocatalyst, CoSnO, decorated on chemically exfoliated boron nitride sheets (CE-BN) with an exceptional capacity to detect electrochemical properties has been prepared by the simple hydrothermal method. The structural, surface morphology and electrochemical characteristics of CoSnO/CE-BN were characterized using a range of physicochemical and electrochemical techniques. Various voltammetric approaches were used to observe the analytical behaviour and applications of CoSnO/CE-BN/GCE for the determination of 2-nitroaniline (2-NA).

Synthesis, characterization, , and investigations and biological assessment of Knoevenagel condensate β-diketone Schiff base transition metal complexes.

A novel Schiff base ligand was synthesized by the Knoevenagel condensation of β-diketone (obtained from substituted Curcumin and Cuminaldehyde) and 4-amino antipyrine. Metal complexes were made from this Schiff base by reacting with metal salts such as Cu(II), Ni(II), Ru(III), VO(IV), and Ce(IV). Physicochemical approaches such as UV-Vis, FT-IR, NMR, EPR, and Mass spectroscopy were used to determine the geometry of the complexes.

Partially purified lead molecules from Dodonaea viscosa and their antimicrobial efficacy against infectious human pathogens.

Background: The utilization of medicinal plants and their drugs have the advantage of reducing side effects compared with manufactured antimicrobials. Artificial drugs have unpleasant side effects, further, the number of drug resistant pathogens is increasing, thus huge challenge for control of resistant pathogens. Therefore, the current research explores the potential of partially purified bioactive compounds from Dodonaea viscosa against certain human pathogens.

Bio-prospective potential of Pleurotus djamor and Pleurotus florida mycelial extracts towards Gram positive and Gram negative microbial pathogens causing infectious disease.

Background: The emergence of resistance to commonly used antibiotics by human infections occurred mostly due to their overuse, that prompted individuals to pursue novel and innovative treatments. The phytochemical characteristics, antibacterial activity, and cytotoxicity of MCF7 cells were evaluated in two Pleurotus spp. mycelial extracts in this work.

Synthesis, characterization, ADMET and o studies of mixed ligand metal complexes from a curcumin Schiff base and lawsone.

Complexes are currently synthesized from plant origin because of their therapeutic effect against certain diseases with toxicity. Hence, in this work, four new transition metal(II) mixed ligand complexes have been synthesized using a curcumin Schiff base (primary ligand) and lawsone (as co-ligand). The geometry of these complexes was explored by elemental analyses, molar conductance, thermal analysis, magnetic moment values, IR, NMR, Mass, electronic and EPR spectral studies.

Spectroscopic, SOD, anticancer, antimicrobial, molecular docking and DNA binding properties of bioactive VO(IV), Cu(II), Zn(II), Co(II), Mn(II) and Ni(II) complexes obtained from 3-(2-hydroxy-3-methoxybenzylidene)pentane-2,4-dione.

Novel macrocyclic Schiff base complexes [[ML]X; where M = Cu(II), Co(II), Ni(II), Zn(II), Mn(II) and VO(IV) L = macrocyclic ligand; X = Cl and SO] have been synthesized and characterized by microanalytical, H, C NMR, IR, Mass, UV-Vis, EPR spectral studies, as well as conductivity data. All the complexes exhibit square-planar geometry except vanadium complex. Magnetic susceptibility measurements and high conductance data reveal the monomeric and electrolytic nature of the complexes.

Biologically active Co (II), Cu (II), Zn (II) centered water soluble novel isoniazid grafted O-carboxymethyl chitosan Schiff base ligand metal complexes: Synthesis, spectral characterisation and DNA nuclease activity.

In this study, the new N, N, O tridentate donor water soluble isoniazid based biopolymer Schiff base ligand and their Co (II), Cu (II), Zn (II) metal complexes were prepared. The compounds were designed for potential biological application such as antibacterial, antifungal, anti-inflammatory, total antioxidant, antidiabetic and DNA binding studies. The synthesized compounds were illuminated in different light sources of various spectra were used to explore the functional groups of Biopolymer derivatives.

Ultrasonication and hydrothermal assisted synthesis of cloud-like zinc molybdate nanospheres for enhanced detection of flutamide.

Ultrasonication is one of the emerging probes for nanoparticles synthesis as well as promoting the material property by treasuring the precious time during a chemical reaction. In this present work, we successfully designed a cloud-like α-ZnMoO nanospheres (ZMNS) using ultrasound assistance (bath sonication with the power of 60 W and frequency of 37/80 kHz) hydrothermal method for catalyzing the effective electrochemical determination of anti-androgen drug candidate flutamide (FLT). The crystallinity and phase purity were investigated using powder X-ray diffractometric analysis.

In Situ Synthesis, Characterization, and Catalytic Performance of Polypyrrole Polymer-Incorporated AgMoO Nanocomposite for Detection and Degradation of Environmental Pollutants and Pharmaceutical Drugs.

Material combinations of semiconductor with conducting polymer are gaining growing interest due to their enhanced activities in photocatalysis as well as electrochemical sensing. In this present work, we report a facile in situ synthesis of polypyrrole (PPy) polymer-incorporated silver molybdate (AgMoO) nanocomposite that is utilized as a photocatalyst and electrocatalyst for the degradation of pollutant heavy metals, namely, methylene blue (MB) and heavy metal (Cr(VI)), and ciprofloxacin (CIP) and for detection of the drug, azomycin. The synthesized nanocomposite was characterized by various theoretical, spectral, and microscopic studies.

Synthesis, characterization and catalytic performance of nanostructured dysprosium molybdate catalyst for selective biomolecule detection in biological and pharmaceutical samples.

The current study reports a new, simple and fast method using a flake-like dysprosium molybdate (Dy2MoO6; FL-DyM) nanostructured material to detect the antibiotic drug metronidazole (METZ). This nanocomposite material was employed on the surface of a glassy carbon electrode (GCE) to develop the electrode (FL-DyM/GCE). Further, the synthesized FL-DyM was systematically characterized by powder X-ray diffraction (XRD), Raman spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray diffraction (EDS), elemental mapping, X-ray photoelectron spectroscopy (XPS), and Brunauer-Emmett-Teller (BET) analyses.

Quantum chemical studies and spectroscopic investigations on 22-amino-3-methyl-5-nitropyridine by density functional theory.

Quantum chemical calculations on energy and molecular structure of 2-amino-3-methyl-5-nitropyridine (2A3M5NP) have been attempted by implementing DFT/B3LYP method using 6-311G (d,p), 6-311G++ (d,p) and cc-pVTZ basis sets. The optimized geometry and the vibrational analysis for energetically most stable configuration, are carried out theoretically by using B3LYP/cc-pVTZ basis set. The computed vibrational frequencies were scaled by using scaling factors and compared with the experimental Fourier Transform Infra-Red (FTIR) solid phase spectrum in the region 4000-400 cm and FT-Raman spectrum in the region 4000-100 cm.

Rational design and facile synthesis of binary metal sulfides VS-SnS hybrid with functionalized multiwalled carbon nanotube for the selective detection of neurotransmitter dopamine.

In this work, we report a sensitive and selective electrochemical sensor for the detection of dopamine (DA) neurotransmitter based on VS-SnS/f-MWCNT hybrids. Herein, the binary metal sulfide (VS-SnS) was synthesized via single step hydrothermal route and hybrids with f-MWCNT via the ultrasonication process. The as-prepared VS-SnS/f-MWCNT hybrids were characterized through the FESEM, EDX and elemental mapping, TEM, XPS, Raman and XRD techniques.

Indole-derived water-soluble N, O bi-dentate ligand-based mononuclear transition metal complexes: and biological screening, molecular docking and macromolecule interaction studies.

A novel tryptophan-derived Schiff base ligand (potassium (E)-2-((4-chloro-3-nitrobenzylidene)amino)-3-(1H-indol-3-yl)propanoate) and a series of its transition metal complexes of the types [ML] and [ML(1,10-phen)]Cl where M = Cu(II), Co(II), Ni(II) and Zn(II) were prepared. They were analyzed by various spectral and physicochemical studies. The XRD data were also used to determine the average lattice parameters and crystalline size of the compounds.

Biological evaluation, molecular docking and DNA interaction studies of coordination compounds gleaned from a pyrazolone incorporated ligand.

In this work, we have synthesized a few novel mononuclear complexes of Cu(II), Co(II), Ni(II) and Zn(II) using a pyrazolone-derived Schiff base ligand. They were characterized by spectroscopic and analytical methods. The elemental analyses, UV-Vis, magnetic moment values and molar conductance of the complexes reveal that the complexes adopt an octahedral arrangement around the central metal ions.

and studies of transition metal complexes derived from curcumin-isoniazid Schiff base.

A series of transition metal complexes have been synthesized from biologically active curcumin and isoniazid Schiff base. They are characterized by various spectral techniques like UV-Vis, Fourier transform infrared (FT-IR), nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR) and mass spectroscopies. Moreover, elemental analysis, magnetic susceptibility and molar conductivity measurements are also carried out.

Ultrasonication-assisted synthesis of sphere-like strontium cerate nanoparticles (SrCeO NPs) for the selective electrochemical detection of calcium channel antagonists nifedipine.

In this work, strontium cerate nanoparticles (SrCeO NPs, SC NPs) were developed through facile synthetic techniques (Ultrasound-Assisted (UA) and Stirring-Assisted (SA) synthesis) and utilized as an electrocatalyst for the selective and sensitive electrochemical detection of calcium channel blocker nifedipine (NDF). The as-prepared UASC NPs and SASC NPs were characterized using XRD, Raman, TEM, EDS, mapping, XPS and BET analysis which exposed the formation of SC NPs in the form of spherical in shape and well crystalline in nature. BET studies reveal that UASC NPs have maximum surface area than that of SASC NPs.

Exploring the DNA interactions, FGF growth receptor interaction and biological screening of metal(II) complexes of NNN donor ligand derived from 2‑(aminomethyl)benzimidazole.

This work deals with a series of biologically important novel transition metal(II) Schiff base chelates containing terpyridine. Benzimidazole, a moiety found in broad spectrum of drugs is espoused in a Schiff base ligand system. Eight such metal(II) complexes are designed, synthesized and characterized.

Simple sonochemical synthesis of novel grass-like vanadium disulfide: A viable non-enzymatic electrochemical sensor for the detection of hydrogen peroxide.

Design and fabrication of novel inorganic nanomaterials for the low-level detection of food preservative chemicals significant is of interest to the researchers. In the present work, we have developed a novel grass-like vanadium disulfide (GL-VS) through a simple sonochemical method without surfactants or templates. As-prepared VS was used as an electrocatalyst for reduction of hydrogen peroxide (HO).

Recent trends in electrochemical biosensors of superoxide dismutases.

Superoxide dismutases (SODs), a family of ubiquitous enzymes, provide essential protection to biological systems against uncontrolled reactions with oxygen- and nitrogen- based radical species. We review first the role of SODs in oxidative stress and the other biological functions such as peroxidase, nitrite oxidase, thiol oxidase activities etc., implicating its role in neurodegenerative, cardiovascular diseases, and ageing.

Probing the potency of triazole tethered Schiff base complexes and the effect of substituents on their biological attributes.

Two triazole-derived Schiff base ligands and their eight octahedral metal(II) complexes were designed and synthesized. They were characterized by elemental analysis and various spectroscopic techniques. The compounds were evaluated for their DNA binding tendencies with Calf thymus DNA.

One-step sonochemical synthesis of 1D β-stannous tungstate nanorods: An efficient and excellent electrocatalyst for the selective electrochemical detection of antipsychotic drug chlorpromazine.

In the modern world, the contamination of ecosystem by human and veterinary pharmaceutical drugs through the metabolic excretion, improper disposal/industrial waste has been subjected to a hot issue. Therefore, exploitation of exclusive structured material and reliable technique is a necessary task to the precise detection of drugs. With this regards, we made an effort for the fabrication of novel one-dimensional (1D) stannous tungstate nanorods (β-SnW NRs) via simple sonochemical approach and used as an electrochemical sensor for the detection of antipsychotic drug chlorpromazine (CPZ) for the first time.