Dynamics of balance indicators, activities of daily living, and quality of life of elderly suffering from Parkinson's disease and frailty after proximal humerus fracture following physiotherapeutic functional training.

Balance dysfunction in elderly patients with Parkinson's disease (PD) is a high-risk fall precaution, along with sarcopenia and senile asthenia, which leads to traumas, including fractures of the proximal humerus fractures (PHF). The objective of the study was to determine the effectiveness of a functional training as part of a physical therapy program on balance, upper limb (UL) function, daily living activities, and quality of life in elderly patients with PD and frailty, following proximal humerus fractures. We examined 33 elderly patients with PD and frailty in the recovery period after PHF.

SUGGESTIONS AND PRESCRIPTIONS FOR MAINTAINING GOOD HEALTH IN «REGIMEN SANITATIS SALERNI» BY ARNOLD OF VILLANOVA.

Objective: The aim: The aim of the study is collection, systematization and comprehensive analysis of suggestions and prescriptions for maintaining good health set forth by Arnold of Villanova in "Regimen Sanitatis Salerni".

Patients And Methods: Materials and methods: The research is based on the first edition of "The Salernitan Rule of Health" (1479) by Arnold of Villanova that comprises 364 poems (103 chapters). In this investigation we consciously leave some later editions of the "Rule" unattended since they contain insertions that do not belong to the author.

DEVELOPMENT OF MEDICAL STUDENTS CREATIVITY AS A PRIORITY OF MODERN HIGHER EDUCATION.

Objective: The aim: To present an overview of the problem of creative skills development at the level of higher education, analyse the notions "creativity" and "creative skills", investigate the main conditions of the creative skills development in medical students of higher educational establishments in Ukraine and abroad.

Patients And Methods: Materials and methods: Experimental verification of the conditions of the medical students creativity development was conducted in the period from 2017 to 2019 academic years within two groups of students: Ukrainian students and foreign students. In the process of the study, the peculiarities of the students' creativity development were established through surveys and questionnaires.

Eco-friendly synthesis of cobalt-zinc ferrites using quince extract for adsorption and catalytic applications: An approach towards environmental remediation.

Cobalt-zinc ferrite nanoparticles were synthesized using environmentally friendly approach with quince extract as a reducing agent. Crystal structure and morphology of the obtained materials were studied by XRD, SEM-EDS, Mössbauer and IR spectroscopy. The synthesized nanoparticles have a cubic spinel structure and crystallite size ranging from 5 to 9 nm.

Two-Step Spin Crossover in Hofmann-Type Coordination Polymers [Fe(2-phenylpyrazine){M(CN)}] (M = Ag, Au).

Two 2D Hofmann-type complexes of the composition [Fe(Phpz){M(CN)}] (where Phpz = 2-phenylpyrazine; M = Ag, Au) have been synthesized, and their spin-crossover (SCO) behavior has been thoroughly characterized. Single-crystal X-ray analysis reveals that these complexes contain a crystallographically unique Fe(II) center surrounded by two axial Phpz ligands and four equatorial cyanide [M(CN)] bridges. It is shown that, using of a ligand with two aromatic rings, an advanced system of weak supramolecular interactions (metal-metal, C-H···M, and π···π stacking contacts) is realized.

Prenatal famine exposure and adult health outcomes: an epigenetic link.

Numerous human chronic pathological conditions depend on epigenetic modifications induced by environmental triggers throughout sensitive stages early in development. Developmental malnutrition is regarded as one of the most important risk factors in these processes. We present an overview of studies that the initiation and progression of many diseases are largely dependent on persisting epigenetic dysregulation caused by environmental insults early in life.

Structurally Dependent Electrochemical Properties of Ultrafine Superparamagnetic 'Core/Shell' γ-FeO/Defective α-FeO Composites in Hybrid Supercapacitors.

The paper presents a method for obtaining electrochemically active ultrafine composites of iron oxides, superparamagnetic 'core/shell' γ-FeO/defective α-FeO, which involved modifying sol-gel citrate synthesis, hydrothermal treatment of the formed sol, and subsequent annealing of materials in the air. The synthesized materials' phase composition, magnetic microstructure, and structural, morphological characteristics have been determined via X-ray analysis, Mossbauer spectroscopy, scanning electron microscopy (SEM), and adsorption porometry. The mechanisms of phase stability were analyzed, and the model was suggested as FeOOH → γ-FeO → α-FeO.

Oxidative Stress and Energy Metabolism in the Brain: Midlife as a Turning Point.

Neural tissue is one of the main oxygen consumers in the mammalian body, and a plentitude of metabolic as well as signaling processes within the brain is accompanied by the generation of reactive oxygen (ROS) and nitrogen (RNS) species. Besides the important signaling roles, both ROS and RNS can damage/modify the self-derived cellular components thus promoting neuroinflammation and oxidative stress. While previously, the latter processes were thought to progress linearly with age, newer data point to midlife as a critical turning point.

Accelerated charge transfer in well-designed S-scheme Fe@TiO/Boron carbon nitride heterostructures for high performance tetracycline removal and selective photo-reduction of CO greenhouse gas into CH fuel.

Designing and fabrication of smart hybrid multifunctional materials for energy/fuel production and environmental detoxification is indeed of great significance for sustainable development. Herein, we synthesized a new well-structured S-scheme heterostructure Fe@TiO/Boron Carbon nitride (FT/BCN) with high performance tetracycline degradation and selective CO photo-reduction to CH. Under visible light irradiation, 96.

Natural sweetener : Functionalities, health benefits and potential risks.

is a South American plant, the cultivation of which is increasing worldwide due to its high content of sweet compounds. sweetness is mainly due to steviol glycosides, that are ~250-300 times sweeter than sucrose. Many studies have suggested the benefits of extract over sugar and artificial sweeteners, but it is still not a very popular sugar substitute.

Acute Exposure to the Penconazole-Containing Fungicide Topas Induces Metabolic Stress in Goldfish.

Triazole fungicides are widely used in agriculture that leads to pollution of freshwater ecosystems. The mechanisms of toxicity to fish by the triazole fungicide Topas that contains penconazole (1-[2-(2,4-dichlorophenyl)pentyl]-1-1,2,4-triazole) have not been studied. The present study aimed to evaluate the effect of goldfish exposure for 96 h to the fungicide Topas at concentrations of 1.

SANITARY AND HYGIENIC EDUCATION OF CHILDREN AND ADULTS UNDER THE CONDITIONS OF THE COVID-19 PANDEMIC IN MEASUREMENT OF THE ACHIEVEMENTS OF PUBLIC MEDICINE OF GALICIA (END OF THE XIX - 30S OF THE XX CENTURY).

Objective: The aim: To analyze the leading trends in sanitary and hygienic education of children and adults in Galicia during the late XIX - the 30s of the XX century and define opportunities to use this historical experience in the current context of the spread of COVID-19 virus in Ukraine.

Patients And Methods: Materials and methods: Chronological, historical, specific search, content-analysis- provide selection and analysis of the source base, allow to determine general trends, directions of development, achievements and gaps of sanitary and hygienic education of children and adults in Galicia in the late XIX - 30sof the XX century; extrapolation and actualization - focus on creative thinking, adaptation and use of this historical experience in today's conditions.

Conclusion: Conclusions: Under the current conditions of the COVID-19 spread, analysis of this retro experience projects to develop a scientific concept of health education, which would outline theoretical approaches to studying this problem, creating a comprehensive state program aimed at preventing infectious diseases, restoration of gene elaboration of clear recommendations on observance of sanitary and hygienic norms and conditions established by quarantine zones, carrying out anti-epidemic measures at educational institutions and among the adult population, informing about prevention and peculiarities of the COVID-19 disease spread, etc.

FRET-based assay for intracellular evaluation of α-synuclein aggregation inhibitors.

Aggregation of small neuronal protein α-synuclein (αSyn) in amyloid fibrils is considered to be one of the main causes of Parkinson's disease. Inhibition of this aggregation is a promising approach for disease treatment. Dozens of compounds able to inhibit αSyn fibrillization in solution were developed during the last decade.

DNA methylation changes induced by prenatal toxic metal exposure: An overview of epidemiological evidence.

Accumulating evidence suggests that exposure to unfavorable conditions early in life can substantially contribute to the risk of chronic disorders later in life ('developmental programming' phenomenon). The mechanistic basis for this phenomenon remains poorly understood so far, although epigenetic mechanisms such as DNA methylation, histone modifications and microRNA-mediated gene regulation apparently play a crucial role. The key role of epigenetic modifications triggered by unfavorable environmental cues during sensitive developmental periods in linking adverse early-life events to later-life health outcomes is evident from a large body of studies, including methylome-wide association studies and research of candidate genes.

Metformin to decrease COVID-19 severity and mortality: Molecular mechanisms and therapeutic potential.

The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 has become a serious challenge for medicine and science. Analysis of the molecular mechanisms associated with the clinical manifestations and severity of COVID-19 has identified several key points of immune dysregulation observed in SARS-CoV-2 infection. For diabetic patients, factors including higher binding affinity and virus penetration, decreased virus clearance and decreased T cell function, increased susceptibility to hyperinflammation, and cytokine storm may make these patients susceptible to a more severe course of COVID-19 disease.

Interplay between reactive oxygen and nitrogen species in living organisms.

In living organisms most oxygen consumed is reduced to water via four-electron reduction. However, few percentages of oxygen are reduced by consecutive one electron mechanisms giving rise to superoxide anion radical, (O), hydrogen peroxide (HO) and hydroxyl radical (HO) and their derivatives collectively called reactive oxygen species (ROS). Nitric oxide (NO) is produced at oxidation of arginine by nitric oxide synthase (NOS) or at reduction of nitrites by diverse reductases.

Chamomile as a potential remedy for obesity and metabolic syndrome.

Obesity is an increasing health concern related to many metabolic disorders, including metabolic syndrome, diabetes type 2 and cardiovascular diseases. Many studies suggest that herbal products can be useful dietary supplements for weight management due to the presence of numerous biologically active compounds, including antioxidant polyphenols that can counteract obesity-related oxidative stress. In this review we focus on , commonly known as chamomile, and one of the most popular medicinal plants in the world.

Optimization of TiO-P25 photocatalyst dose and HO concentration for advanced photo-oxidation using smartphone-based colorimetry.

Color images taken by a smartphone camera were used to estimate the rate of advanced photo-oxidation reaction of Direct Red 23 (DR23) azo dye as a model organic pollutant. The red, green, blue color coordinates were tested to quantify the dye. Images of the reaction mixture were taken at specified intervals to obtain kinetic lines and reaction rate constants.

Difference in Performance of EPI Pigs Fed Either Lipase-Predigested or Creon®-Supplemented Semielemental Diet.

Pancreatic enzyme replacement therapy (PERT) and fat predigestion are key in ensuring the optimal growth of patients with cystic fibrosis. Our study attempted to highlight differences between fat predigestion and conventional PERT on body composition of young pigs with exocrine pancreatic insufficiency (EPI). EPI and healthy pigs were fed with high-fat diet for six weeks.

Oxidative stress concept updated: Definitions, classifications, and regulatory pathways implicated.

Reactive oxygen species were discovered in living organisms in the early 1950's and their action has been implicated in diverse biological processes. First formulated by H. Sies in 1985[57], the oxidative stress concept stimulated substantial interest in reactive oxygen species and it is now common that fundamental research in various biomedical fields includes mention of research on the involvement of oxidative stress.

Factors that regulate expression patterns of insulin-like peptides and their association with physiological and metabolic traits in Drosophila.

Insulin-like peptides (ILPs) and components of the insulin signaling pathway are conserved across different animal phyla. Eight ILPs (called DILPs) and two receptors, dInR and Lgr3, have been described in Drosophila. DILPs regulate varied physiological traits including lifespan, reproduction, development, feeding behavior, stress resistance and metabolism.

Spin crossover in iron(II) Hofmann clathrates analogues with 1,2,3-triazole.

Hofmann-like cyanometallic complexes represent one of the biggest and well-known classes of FeII spin-crossover compounds. In this paper, we report on the first FeII Hofmann clathrate analogues with unsubstituted 1,2,3-triazole, which exhibit temperature induced spin transition. Two new coordination polymers with the general formula [FeII(1,2,3-triazole)2MII(CN)4] (M = Pt, Pd) undergo abrupt hysteretic spin crossover in the range of 190-225 K as revealed by magnetic susceptibility measurements.

Sex differences in the phylum-level human gut microbiota composition.

Background: Evidence was previously provided for sex-related differences in the human gut microbiota composition, and sex-specific discrepancy in hormonal profiles was proposed as a main determinant of these differences. On the basis of these findings, the assumption was made on the role of microbiota in the sexual dimorphism of human diseases. To date, sex differences in fecal microbiota were demonstrated primarily at lower taxonomic levels, whereas phylum-level differences between sexes were reported in few studies only.