57 results match your criteria: "VA Health Services Research and Development Center of Innovation[Affiliation]"
medRxiv
October 2024
VA Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Health Care System.
Epigenetic measures of aging derived from DNA methylation are promising biomarkers associated with prospective morbidity and mortality, but require validation in real-world medical settings. Using data from 2,216 post-9/11 veterans, we examined whether accelerated DunedinPACE aging scores were associated with chronic disease morbidity, predicted healthcare costs, and mortality assessed over an average of 13.1 years of follow up in VA electronic health records.
View Article and Find Full Text PDFJ Psychiatr Res
June 2024
VA Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Health Care System, USA; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, USA.
Exposure to toxins-such as heavy metals and air pollution-can result in poor health and wellbeing. Recent scientific and media attention has highlighted negative health outcomes associated with toxic exposures for U.S.
View Article and Find Full Text PDFPsychiatry Res
June 2024
VA Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Health Care System; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine; VA Health Services Research and Development Center of Innovation to Accelerate Discovery and Practice Transformation, Durham VA Health Care System.
Measures of epigenetic aging derived from DNA methylation (DNAm) have enabled the assessment of biological aging in new populations and cohorts. In the present study, we used an epigenetic measure of aging, DunedinPACE, to examine rates of aging across demographic groups in a sample of 2,309 United States military veterans from the VISN 6 MIRECC's Post-Deployment Mental Health Study. As assessed by DunedinPACE, female veterans were aging faster than male veterans (β = 0.
View Article and Find Full Text PDFJ Subst Use Addict Treat
May 2024
Durham VA Health Care System, Durham, NC, USA; VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center, Durham, NC, USA; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA; VA Health Services Research and Development Center of Innovation to Accelerate Discovery and Practice Transformation, Durham, NC, USA.
Introduction: Alcohol use disorder (AUD) is prevalent among veterans, and excessive alcohol use is associated with significant mental and physical health consequences. Currently, the largest cohort of veterans seeking services at the VA are those from the 1990s Gulf War Era. This cohort of veterans is unique due to the nature of their deployment resulting in a myriad of unexplained symptoms collectively known as "Gulf War Illness" and higher rates of mental health problems.
View Article and Find Full Text PDFTransl Psychiatry
January 2024
VA Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Health Care System, Durham, USA.
People who experience trauma and develop posttraumatic stress disorder (PTSD) are at increased risk for poor health. One mechanism that could explain this risk is accelerated biological aging, which is associated with the accumulation of chronic diseases, disability, and premature mortality. Using data from 2309 post-9/11 United States military veterans who participated in the VISN 6 MIRECC's Post-Deployment Mental Health Study, we tested whether PTSD and trauma exposure were associated with accelerated rate of biological aging, assessed using a validated DNA methylation (DNAm) measure of epigenetic aging-DunedinPACE.
View Article and Find Full Text PDFBehav Sleep Med
June 2024
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.
Drug Alcohol Depend Rep
September 2023
Durham VA Health Care System, Durham NC, USA.
Background: Shame and guilt are key emotions known to amplify trauma-related symptoms in veterans. Maintenance of symptoms is facilitated by avoidance behaviors, such as substance use. However, limited research has examined the associations between shame, guilt, and substance use in daily life.
View Article and Find Full Text PDFJ Affect Disord
November 2023
Trauma Research Consortium at Baylor Scott & White Health, Waco, TX, USA; Texas A&M University Health Science Center, College of Medicine, College Station, TX, USA.
Psychosom Med
June 2023
From the Geriatric Research, Education, and Clinical Center (Bourassa, Hall, Taylor), Durham VA Healthcare System; Department of Psychology and Neuroscience (Caspi, Brennan, Harrington, Houts, Moffitt), Duke University, Durham, North Carolina; Institute of Psychiatry, Psychology and Neuroscience (Caspi, Moffitt), King's College London, London, United Kingdom; Center for the Study of Population Health & Aging (Caspi, Moffitt), Duke University Population Research Institute; Center for the Study of Aging and Human Development (Caspi, Brennan, Hall, Taylor, Moffitt), and Department of Medicine, Division of Geriatrics (Hall, Taylor), Duke University; VA Mid-Atlantic Mental Illness Research, Education and Clinical Center (Kimbrel), and VA Health Services Research and Development Center of Innovation to Accelerate Discovery and Practice Transformation (Kimbrel), Durham VA Healthcare System; Department of Psychiatry and Behavioral Sciences (Kimbrel), Duke University School of Medicine, Durham, North Carolina; Department of Psychology (Poulton, Ramrakha), University of Otago, Otago, New Zealand; and Department of Immunology (Taylor), Duke University Medical Center, Durham, North Carolina.
Objective: Stress and stressful events are associated with poorer health; however, there are multiple ways to conceptualize and measure stress and stress responses. One physiological mechanism through which stress could result in poorer health is accelerated biological aging. This study tested which types of stress were associated with accelerated biological aging in adulthood.
View Article and Find Full Text PDFJ Trauma Stress
June 2023
VA Puget Sound Health Care System, Seattle Division, Seattle, Washington, USA.
Posttraumatic stress disorder (PTSD) is linked to negative relationship outcomes, but the relational processes that link specific PTSD symptoms to these outcomes over granular periods are not well understood. The current study used a daily diary methodology to investigate the associations between specific PTSD symptoms (i.e.
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