2,889 results match your criteria: "VA HSR&D Center for Chronic Disease Outcomes Research CCDOR[Affiliation]"

Background: A welcoming environment may influence patient care experiences, and it may be particularly relevant for underrepresented groups, such as women veterans at Veterans Health Administration (VA) facilities where they represent only 8-10% of patients. Challenges to ensuring a welcoming environment for women veterans may include unwelcome comments from male veterans and staff or volunteers and feeling unsafe inside or outside VA facilities. We assessed associations between reports of gender-related environment of care problems and patient-reported outcomes.

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Anhedonia is associated with higher functional connectivity between the nucleus accumbens and paraventricular nucleus of thalamus.

J Affect Disord

December 2024

Center for the Neurobiology of Learning and Memory, University of California, Irvine 92697, USA; Department of Neurobiology and Behavior, University of California, Irvine 92697, USA; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697, USA. Electronic address:

Background: Anhedonia stands as a life-threatening transdiagnostic feature of many mental illnesses, most notably major depression and involves neural circuits for processing reward information. The paraventricular nucleus of the thalamus (PVT) is associated with reward-seeking behavior, however, links between the PVT circuit and anhedonia have not been investigated in humans.

Methods: In a sample of adults with and without psychiatric symptoms (n = 75, 18-41 years, 55 female), we generated an anhedonia factor score for each participant using a latent factor analysis, utilizing data from depression and anxiety assessments.

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Key Points: Treatment discontinuation is common among patients with CKD prescribed sodium-glucose cotransporter-2 (SGLT2) inhibitors (discontinued in 37%) or glucagon-like peptide-1 receptor agonists (GLP-1 RA; discontinued in 47%). Discontinuation of SGLT2 inhibitors and GLP-1 RA was associated with recent hospitalizations, Black race, Hispanic ethnicity, and vascular disease. Discontinuation of both agents was associated with death and cardiovascular events.

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Collaborative care management (CoCM) is an evidenced based approach to psychiatric treatment in primary care, yet literature examining factors associated with program adherence is lacking. This study analyzed predictors of adherence to a CoCM model of psychopharmacological treatment of depression and anxiety in primary care by conducting a retrospective cohort analysis on Veterans referred to a large VA Medical Center's CoCM program over an 18-month period. Baseline characteristics, symptomatic assessments, and covariates of interest were collected.

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Article Synopsis
  • The study looked at people with and without hand osteoarthritis to find out who has marginal erosions (MEs), which are small damage spots in the bones.
  • It discovered that MEs are more common in older men who smoke and usually happen in joints that don’t have a lot of arthritis.
  • Lastly, MEs could help predict how the condition might get worse over time, since they are linked to more changes in bone damage compared to joints without MEs.
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Evolution of the Veterans Health Administration Learning Health System: 25 years of QUERI.

Health Serv Res

December 2024

Health Systems Research, Office of Research & Development, Veterans Health Administration, US Department of Veterans Affairs, Washington, DC, USA.

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Objective: To examine the relationship between the penetration (or reach) of a national program aiming to integrate mental health clinicians into all primary care clinics (PC-MHI) and rates of guideline-concordant follow-up and treatment among clinic patients newly identified with depression in the Veterans Health Administration (VA).

Data Sources/study Setting: 15,155 screen-positive patients 607,730 patients with 2-item Patient Health Questionnaire scores in 82 primary care clinics, 2015-2019.

Study Design: In this retrospective cohort study, we used established depression care quality measures to assess primary care patients who (a) newly screened positive (score ≥3) and (b) were identified with depression by clinicians via diagnosis and/or medication (n = 15,155; 15,650 patient-years).

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Background: Exercise intolerance is common among adults with heart failure (HF) and is a strong prognostic indicator. We examined maximal inspiratory pressure (MIP) as an indicator of maximal and submaximal exercise capacity in older HF patients.

Methods: Fifty-one patients age ≥ 50 years with HF underwent MIP testing via the PrO device.

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Unseen foe: The financial toxicity of liver transplantation.

Liver Transpl

September 2024

Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.

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Racial and Ethnic Disparity in Healthcare Expenditure and Resource Utilization Among Patients with Cardiovascular Diseases.

J Racial Ethn Health Disparities

August 2024

Pharmaceutical Health Outcomes and Policy Department, College of Pharmacy, University of Houston, Texas Health Building 2, 4849 Calhoun Road, Room 4050, Houston, TX, 77204-5047, USA.

Background: Despite extensive research, significant gaps remain in understanding racial disparity among individuals with cardiovascular diseases (CVD). These disparities, influenced by factors such as access to care and comorbid conditions, necessitate further investigation to develop targeted interventions.

Aim: To evaluate the factors contributing to racial and ethnic disparities in healthcare resource utilization and total healthcare expenditure among individuals with CVD.

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Article Synopsis
  • The study aimed to evaluate the impact of the iHI-FIVES caregiver training program on the number of days Veterans spend away from home and the well-being of their family caregivers.
  • Involvement included 898 Veterans from 8 medical centers, comparing data from before and after implementing the program through a randomized trial.
  • Results indicated a 42% reduction in Veteran days not at home after joining iHI-FIVES, but no significant changes were found in caregiver well-being over the same period.
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Background: Extracorporeal membrane oxygenation (ECMO) represents an important but limited treatment for patients with severe COVID-19. We assessed the effects of an educational intervention on a person's ECMO care preference and examined whether patients and providers had similar ECMO preferences.

Methods: In the Video+Survey group, patients watched an educational video about ECMO's purpose, benefits, and risks followed by an assessment of ECMO knowledge and care preferences in seven scenarios varying by hypothetical patient age, function, and comorbidities.

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Objective: Posttraumatic stress disorder (PTSD) has been linked with menopause symptoms (eg, vasomotor, urinary) and their sequelae (eg, sexual difficulties). However, PTSD is a heterogeneous disorder, and less is known about which aspects may be most associated with menopause-related health.

Methods: Using confirmatory factor analyses, we evaluated five structural models of PTSD symptoms in 208 predominately postmenopausal women veterans (aged 45-64 years).

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Objective: To determine whether mandatory participation by hospitals in bundled payments for lower extremity joint replacement (LEJR) was associated with changes in outcome disparities for patients dually eligible for Medicare and Medicaid.

Data Sources And Study Setting: We used Medicare claims data for beneficiaries undergoing LEJR in the United States between 2011 and 2017.

Study Design: We conducted a retrospective observational study using a differences-in-differences method to compare changes in outcome disparities between dual-eligible and non-dual eligible beneficiaries after hospital participation in the Comprehensive Care for Joint Replacement (CJR) program.

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Prevalence, Features, and Outcomes of Type 1 Neovascularization in Eyes with Angioid Streaks.

Ophthalmol Retina

August 2024

School of Medicine, Vita-Salute San Raffaele University, Milan, Italy; Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Article Synopsis
  • The study investigated neovascularization (NV) in patients with angioid streaks (AS) due to pseudoxanthoma elasticum (PXE), aiming to explore its characteristics and outcomes while also proposing a classification system based on various imaging techniques.
  • It analyzed data from 85 patients, noting that 76% had type 1 NV, primarily around the optic disc, with many cases remaining nonexudative over five years, yet some progressed to more severe forms, increasing the risk of vision loss.
  • The research concluded that type 1 NV is common and can lead to significant visual impairment, while a newly developed classification system for AS ranges from non-NV stages to those with advanced NV
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The Discrepancy Between Visual Acuity Decline and Foveal Involvement in Geographic Atrophy.

Ophthalmol Retina

January 2025

School of Medicine, Vita-Salute San Raffaele University, Milan, Italy; Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Purpose: To investigate the discrepancy between visual acuity (VA) decline and foveal involvement in geographic atrophy (GA) secondary to nonexudative age-related macular degeneration (AMD), and to explore how early retinal changes impact the progression of visual impairment.

Design: Retrospective, longitudinal cohort study.

Subjects: This study evaluated 80 eyes from 60 patients (mean age, 74.

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Article Synopsis
  • The study investigates the relationship between the timing of traumatic brain injury (TBI) and mortality in veterans with epilepsy, finding that TBI increases mortality risk, especially when it occurs shortly after epilepsy onset.
  • Among almost 1 million veterans, those with epilepsy had a significantly higher mortality rate compared to controls, with the most severe risk observed in those with TBI within 6 months of epilepsy diagnosis.
  • Results indicate that the timing of TBI in relation to epilepsy is crucial, highlighting a need for targeted care for veterans experiencing these conditions.
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Article Synopsis
  • The study aimed to evaluate the effectiveness of a team collaboration strategy called CONNECT in improving the implementation of a caregiver training program for veterans, known as iHI-FIVES.
  • It involved a stepped wedge cluster randomized trial across eight VA medical centers, comparing the outcomes of sites using CONNECT plus technical support (REP) against those using REP alone.
  • Findings showed high training fidelity (88%), but better reach (22% vs. 14%) and fidelity (95% vs. 80%) at non-CONNECT sites, indicating that CONNECT did not significantly enhance team functioning or program reach.
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Relationships Between Applied Mindfulness Practice, Chronic Pain, and Pain-Related Functioning in Veterans.

J Pain

November 2024

VA HSR&D Center for Care Delivery and Outcomes Research, VA Medical Center, Minneapolis, Minnesota; Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota.

Mindfulness-based interventions (MBIs) have been shown to improve chronic pain and associated conditions like depression, anxiety, and sleep disorders. However, there is limited research on how veterans with chronic pain apply mindfulness skills to manage pain in daily life. This cross-sectional study examined the association between applied mindfulness practice, pain, and several pain-related conditions among 1,737 veterans with chronic pain prior to enrollment in a trial of 2 MBIs.

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Objective: To identify organizational service features associated with positive patient ratings of primary care within primary care clinics tailored to accommodate persons with ongoing and recent experiences of homelessness (PEH).

Data Sources And Study Setting: PEH receiving primary care in 29 United States Veterans Health Administration homeless-tailored clinics were surveyed about their primary care experience using the validated Primary Care Quality-Homeless (PCQ-H) survey. Characteristics of the clinics were assessed through surveys of clinic staff using a new organizational survey developed through literature review, site visits, statistical analysis, and consensus deliberation.

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Background: Although studies are increasingly adopting online protocols, few such studies in the addiction field have comprehensively described their data review procedures and successes in detecting low-quality/fraudulent data. The current study describes data collection protocols and outcomes of a large, longitudinal study (the PAL Study 2021) that implemented online design elements to study individuals seeking peer support for an alcohol use disorder.

Methods: In 2021, the PAL Study collaborated with mutual-help group (MHG) partners and recovery-related organizations to recruit individuals attending a 12-step group, Women for Sobriety (WFS), LifeRing Secular Recovery, and/or SMART Recovery for an alcohol problem in-person and/or online in the prior 30 days.

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Objective: To examine the relationship between site-level adaptation and early adoption of Caregivers Finding Important Resources, Support, and Training (FIRST) training during national implementation across diverse Veteran Health Administration (VA) medical centers.

Data Sources And Study Setting: We enrolled and evaluated 25 VA medical centers (VAMCs). Along with administrative data on site characteristics, we examined site-reported data on adaptations and intervention adoption, defined as ≥4 training classes delivered to ≥5 caregivers at 6 months from April through October 2022.

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