STUDY OF BONE TISSUE REPARATION AFTER A FEMUR FRACTURE DEPENDING ON THE CORRECTION OF ARTERIAL HYPERTENSION IN MODEL OBJECT RATTUS NORVEGICUS (RAT GRAY).

The processes of bone remodeling and regulation of blood pressure are caused by common genetic determinants underlying the development of these diseases. To solve practical medical problems, it seems relevant to carry out the correction and treatment of syntropic diseases at the same time with the aim of achieving the maximum positive effect. The most serious complication of osteoporosis is bone fractures, especially fractures of the proximal femur, which are a serious medical and social problem.

About the Aromaticity of symm-Triaminotrinitrobenzene.

Aromaticity and structural features of the isolated symm-triaminotrinitrobenzene (TATB) were examined using the nonempirical ab initio quantum chemical method and molecular dynamics at the Car-Parrinello level. Different criteria of the aromaticity were combined with the study of conformational flexibility of molecule and analysis of the electron density distribution. It was found that the cooperative effect of the resonance-assisted hydrogen bonds results in the ultimate decreasing aromaticity of the benzene ring in TATB.

[Effect of experimental acute postnatal and mixed hypoxia on the morphological state of the rats liver stromal component].

Objective: Introduction: In children population of Ukraine the diseases of the gastrointestinal tract are quite common, among which a significant number of cases occur in liver diseases. The complexity of the liver functions formation in antenatal and intranatal periods, its morphofunctional immaturity lead to the high sensitivity of this organ to the influence of various factors from the mother organism. Actual issues are the detection of the mother's pathology influence on the formation of diseases «cargo» in children remote stages of ontogenesis.

[FINANCIAL AND LEGAL GUARANTEEING OF MEDICAL INSURANCE IN UKRAINE].

The objective of the research is to study the main financial and legal problems of medical insurance in Ukraine and the search for the ways of its improvement. The authors have used general scientific, special and legal methods in the process of writing the scientific article. Thus, the system method was used to study medical insurance as a type of social insurance; the structural - for studying the types of medical services provided by medical insurance; functional - to establish the subject of compensation for damage according to the results of insurance claims and to reveal its powers; comparative and legal - for the analysis of international and national theories that define the basis for organizing medical insurance and the sources of funding medical services.

LEGAL REGULATION OF PROCUREMENT OF NARCOTIC DRUGS IN UKRAINE WITH INVOLVEMENT OF INTERNATIONAL SPECIALIZED ORGANIZATIONS.

The purpose of the study is to analyze specific problems of legal regulation of the procurement of narcotic drugs in Ukraine with the involvement of international specialized organizations. To achieve this goal, statistics have been analyzed concerning the number of people who receive narcotic drugs for the SMT program, the number of their treatment applications, the quantity of drugs purchased for them from the state budget. It is proposed to divide the regulatory legal acts regulating the purchase of narcotic drugs, general and special, and analyze them.

The role of smart technology in promoting the right to health of older persons.

Objective: Introduction: The right to health is one of the fundamental human rights. Due to the fact that older persons are requiring special treatment in medical care international law pays particular attention to the issue of securing their specified right. Nowadays new forms of health-care are being established, in particular, by using the latest technologies that facilitate access to healthcare services.

General cardiovascular risk and functional indicators of the permanent atrial fibrillation.

Objective: Introduction: No doubt today that atrial fibrillation (AF) is associated with an increased risk of thromboembolic events. Simultaneously we did not find any investigation about the links between general cardiovascular risk (GCVR) and the frequency forms and functional parameters of the heart in patients with AF. The aim: To study the frequency forms and functional indices of the heart in patients with permanent AF in GCVR groups.

Hartman effect for spin waves in exchange regime.

Hartman effect for spin waves tunnelling through a barrier in a thin magnetic film is considered theoretically. The barrier is assumed to be created by a locally increased magnetic anisotropy field. The considerations are focused on a nanoscale system operating in the exchange-dominated regime.

Microwave emission from superconducting vortices in Mo/Si superlattices.

Most of superconductors in a magnetic field are penetrated by a lattice of quantized flux vortices. In the presence of a transport current causing the vortices to cross sample edges, emission of electromagnetic waves is expected due to the continuity of tangential components of the fields at the surface. Yet, such a radiation has not been observed so far due to low radiated power levels and lacking coherence in the vortex motion.

Trichologist, Dermatotrichologist, or Trichiatrist? A Global Perspective on a Strictly Medical Discipline.

Few dermatologic problems carry as much emotional overtones as the complaint of hair loss. The best way to alleviate the distress related to hair loss is to effectively treat it. In fact, one of the oldest medical professions is the Egyptian physician who specialized on diseases of the head.

Low-dimensional compounds containing cyanido groups. Part XXXV. Structure, spectral, thermal and magnetic properties of a binuclear Cu-biquinoline complex with bridging and terminal dicyanamide ligands.

From the system CuCl-biq-NaN(CN) (biq is 2,2'-biquinoline), the binuclear molecular complex bis(μ-dicyanamido-κN:N)bis[(2,2'-biquinoline-κN,N')(dicyanamido-κN)copper(II)], [Cu(CN)(CHN)] or [Cu(biq)(dca)(μ-dca)] (1) [dca is dicyanamide, N(CN)] was isolated and characterized by crystal structure analysis, and spectral, thermal and magnetic measurements. IR spectroscopy confirmed the presence of the biq and dca ligands in 1. Its solid-state structure consists of discrete centrosymmetric binuclear copper(II) units with double end-to-end dca bridges.

Mol-ecular and crystal structure of methyl 4-methyl-2,2-dioxo-1-2λ,1-benzo-thia-zine-3-carboxyl-ate.

The title compound, CHNOS, possesses weak analgesic properties and is a source compound for the synthesis of highly active analgesic and anti-inflammatory compounds. The benzo-thia-zine ring adopts a conformation intermediate between twist-boat and sofa. The ester substituent is turned towards the endocyclic double bond because of steric repulsion.

New Antarctic deep-sea weird leech (Hirudinida: Piscicolidae): morphological features and phylogenetic relationships.

A new fish leech Ambulobdella shandikovi n. g., n.

PHARMACOGENETIC EFFECTS OF METHOTREXATE (MTX) IN UKRAINIAN PATIENTS DEPENDING ON THE MTHFR GENOTYPES (CLINICAL CASES).

The aim of the study is an evaluation the influence of MTHFR gene polymorphisms in the response to MTX in Ukrainian patients. The study group included unrelated Ukrainian patients with dermatoses - psoriasis vulgaris, psoriasis arthritis, psoriasis erythrodermic, atopic dermatitis, scleroderma, eczema, flat lichen and ectopic pregnancy. The materials for this study are based on the accumulated data from clinical observations of different reactions of patients with dermatoses and ectopic pregnancies when using methotrexate as the basic therapy according protocols.

[FUNCTIONAL PARAMETERS OF BLOOD CIRCULATION IN FIRST THREE MONTHS AFTER RADIOFREQUENCY ABLATION OF ATRIAL FIBRILLATION AND FLUTTER].

The purpose of the study was to evaluate functional parameters of blood circulation in first 3 months after radiofrequency ablation of atrial fibrillation and atrial flutter. The study included 113 patients aged 59.3±10.

Lipid Bilayer Interactions of Amyloidogenic N-Terminal Fragment of Apolipoprotein A-I Probed by Förster Resonance Energy Transfer and Molecular Dynamics Simulations.

The effects of one of the amyloidogenic mutations of apolipoprotein A-I (apoA-I), G26R, on the thermal stability, structural dynamics and lipid-associating properties of the 1-83 N-terminal fragment of apoA-I (A83) have been investigated using the Förster resonance energy transfer (FRET) and molecular dynamics (MD) simulation. The measurements of FRET between the tryptophan residues of the single Trp variants of A83 as donors and the membrane-incorporated fluorescent probe 4-dimethylaminochalcone as an acceptor provided evidence for a less depth of A83/G26R penetration into phosphatidylcholine (PC) bilayer compared to WT counterpart. The unfolding MD simulations showed that G26R mutation destabilizes the overall structure of A83, with individual alpha-helices differing in their thermal stability.

New and Interesting Fungi. 1.

This study introduces two new families, one new genus, 22 new species, 10 new combinations, four epitypes, and 16 interesting new host and / or geographical records. (based on ) is introduced as new family, with three new combinations. (based on ) is introduced to accommodate gen.

Crystal structure of ethyl 2-methyl-5,10-dioxo-4-phenyl-5,10-di-hydro-4-11-thia-1,4a-di-aza-benzo[]fluorene-3-carb-oxy-late.

The title compound, CHNOS, crystallizes in the ortho-rhom-bic 222 space group, indicating the existence of only one enanti-omer with an configuration of the chiral center in the crystal phase. The di-hydro-pyrimidine ring adopts a twist-boat conformation while the quinone ring is slightly non-planar. In the crystal, mol-ecules are linked by weak C-H⋯O and C-H⋯S hydrogen bonds and C-H⋯π inter-actions.

Synthesis, Crystal Structure, and Biological Activity of Ethyl 4-Methyl-2,2-dioxo-1-2λ⁶,1-benzothiazine-3-carboxylate Polymorphic Forms.

Continuing the search for new potential analgesics among the derivatives of 4-methyl-2,2-dioxo-1-2λ⁶,1-benzothiazine-3-carboxylic acid, the possibility of obtaining its esters by the alkylation of the corresponding sodium salt with iodoethane in dimethyl sulfoxide (DMSO) at room temperature was studied. It was found that under such conditions, together with the oxygen atom of the carboxyl group, a heteroatom of nitrogen is also alkylated. Therefore, the product of the reaction studied is a mixture of ethyl 4-methyl-2,2-dioxo-1-2λ⁶,1-benzothiazine-3-carboxylate (major) and its 1-ethyl-substituted analog (minor).

Dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-4-ones as a new class of CK2 inhibitors.

Identification of new small molecules inhibiting protein kinase CK2 is highly required for the study of this protein's functions in cell and for the further development of novel pharmaceuticals against a variety of disorders associated with CK2 activity. In this article, a virtual screening of a random small-molecule library was performed and 12 compounds were initially selected for biochemical tests toward CK2. Among them, the most active compound 1 ([Formula: see text]) belonged to dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-4-ones.

Descriptive Modeling of the Dynamical Systems and Determination of Feedback Homeostasis at Different Levels of Life Organization.

The state-of-art research in the field of life's organization confronts the need to investigate a number of interacting components, their properties and conditions of sustainable behaviour within a natural system. In biology, ecology and life sciences, the performance of such stable system is usually related to homeostasis, a property of the system to actively regulate its state within a certain allowable limits. In our previous work, we proposed a deterministic model for systems' homeostasis.

A study of enterocyte membranes during activation of apoptotic processes in chronic carrageenan-induced gastroenterocolitis.

Aim To investigate the lipid membranes of rat enterocytes in chronic carrageenan-induced gastroenterocolitis accompanied by the activation of apoptotic processes. Methods Steady-state fluorescence spectroscopy: a study by fluorescent probes - by ortho-hydroxy derivatives of 2,5-diaryl-1,3- oxazole. Activity of apoptosis signal-regulating kinase 1 and poly (ADP-ribose) polymerase in small intestinal homogenates, blood serum levels of matrix metalloproteinase-2 and caspase-3 and the level of DNA fragmentation in small intestinal homogenates were determined.

[Morphological characteristics of kidneys connective tissue of mature fetuses and newborns from mothers, whose pregnancy was complicated by preeclampsia of varying degrees of severity].

Objective: Introduction: The kidneys connective tissue condition in the antenatal period affects the formation of tissues and it changes with the development of various general pathological processes in this organ. The aim of the study was to identify the morphological features of kidneys connective tissue of fetuses and newborns from mothers whose pregnancy was complicated by preeclampsia of varying degrees of severity.

Patients And Methods: Materials and methods: The material of the study was the tissue of kidneys of mature fetuses and newborns from mothers with physiological pregnancy (28 cases), as well as from mothers whose pregnancy was complicated by preeclampsia of varying degrees of severity (78 cases).

A Cu complex with an carbamoylcyanonitrosomethanide ligand formed in situ by the nucleophilic addition of water to dicyanonitrosomethanide: structure, spectral and magnetic properties.

The complex (2,2'-biquinoline-κN,N')(carbamoylcyanonitrosomethanide-κN,O)chloridocopper(II) acetonitrile monosolvate, [Cu(CHNO)Cl(CHN)]·CHCN or [Cu(ccnm)Cl(biq)]·acn (acn is acetonitrile, biq is 2,2'-biquinoline and ccnm is carbamoylcyanonitrosomethanide), (I), was prepared as a result of nucleophilic addition of water to the dicyanonitrosomethanide ion in the presence of Cu and biq. IR spectroscopy confirmed the presence of ccnm, biq and acn in (I). The solid-state structure consists of the neutral complex containing ccnm and biq ligands, coordinated to the Cu atom in a bidendate chelating manner, and a chloride ligand, resulting in a distorted tetragonal pyramidal coordination of Cu.