MEDICAL ASPECTS OF VIOLATION OF THE RIGHT TO LIFE IN THE CONTEXT OF THE EUROPEN COURT OF HUMAN RIGHTS CASE LAW.

Objective: The aim: The purpose of the paper is to raise awareness of the medical services subjects in the issues of establishment of the relationship between their activities and harm to patients, analysis of the case law of the ECHR and provision of practical recommendations for the prevention of violations of Art. 2 of the Convention with subsequent compensation for non-pecuniary and pecuniary damage.

Patients And Methods: Materials and methods: The authors used the judgements of the European Court of Human Rights (ECHR) on medical research, international regulatory acts, publications of scholars in the field of medical law and legal doctrine in terms of liability of medical services providers for the violation of Art.

ELECTROENCEPHALOGRAPHIC MONITORING OF THE BRAIN FUNCTIONAL CONDITION IN MODERN UKRANIAN SCHOOLCHILDREN.

Objective: The aim: To monitor the brain functional state of generally healthy Ukrainian schoolchildren according to computer electroencephalography (EEG).

Patients And Methods: Materials and methods: EEG examination of 125 practically healthy (according to medical records) schoolchildren of both sexes, which were divided into 3 age groups: 1) 8-12 years old (n = 49); 2) 13-16 years old (n = 42); 3) 17-18 years old (n = 34). EEG was recorded at rest with eyes closed and during functional tests (eye opening, hyperventilation).

Human Health Risk Assessment on the Consumption of Apples Growing in Urbanized Areas: Case of Kharkiv, Ukraine.

This study aims to determine the safety of consumption of plant products grown in Kharkiv, Ukraine. Kharkiv, as well as many other post-Soviet cities, is environmentally characterized by the widespread growing of edible plants-from industrial areas to school gardens-as well as the presence of a significant number of nature management conflicts, the location of heavy industry, the prevalence of obsolete environmentally unfriendly transport, etc. The article presents the results of the study of apple samples taken in different functional zones of Kharkiv city, Ukraine.

Synthesis and Adsorption Properties of Gadolinium-Imprinted Divinylbenzene-Based Copolymers.

Ion-imprinted divinylbenzene and methacrylic acid copolymers for rare-earth element adsorption with crosslink ratios 60 and 40% have been synthesized. Ion imprinting has been carried out via the trapping approach. Alizarin red S has been incorporated in the polymers as a nonvinylated ligand.

Usage of Quantum Chemical Methods to Understand the Formation of Concomitant Polymorphs of Acetyl 2-(-(2-Fluorophenyl)imino)coumarin-3-carboxamide.

Crystallization of concomitant polymorphs is a very intriguing process that is difficult to be studied experimentally. A comprehensive study of two polymorphic modifications of acetyl 2-(-(2-fluorophenyl)imino)coumarin-3-carboxamide using quantum chemical methods has revealed molecular and crystal structure dependence on crystallization conditions. Fast crystallization associated with a kinetically controlled process results in the formation of a columnar structure with a nonequilibrium molecular conformation and more isotropic topology of interaction energies between molecules.

Phytochemical and Psychotropic Research of Motherwort ( L.) Modified Dry Extracts.

The prospect of creating a new medicine with psychotropic activity is shown as a result of studying the chemical composition and pharmacological activity of modified dry extracts of motherwort ( L.) tincture. The most promising substances were the dry extracts, modified by adding small amounts of arginine, valine, phenylalanine, glycine, lysine, and alanine.

Probing the interactions of novel europium coordination complexes with serum albumin.

Molecular interactions between novel europium coordination complexes (EC) possessing superior cytotoxic activity and bovine serum albumin (BSA), the most prominent representative of plasma proteins, were assessed using fluorescence spectroscopy and molecular docking techniques. Cumulative results from fluorescent probe binding, fluorescence quenching and Förster resonance energy transfer studies revealed that the europium complexes V4 and V8 do not perturb the BSA structure, while V3, V5, and V7 induce partial unfolding of the polypeptide chain. Molecular docking studies coupled with analysis of the three-dimensional structure of the BSA-EC complexes showed that V4 and V8 reside in the vicinity of the protein IIA subdomain (Sudlow's site I), while V3, V5 and V5 were localized predominantly in the BSA IIIA subdomain (Sudlow's site II).

Polymorphism of methyl 4-amino-3-phenylisothiazole-5-carboxylate: an experimental and theoretical study.

Being a close analogue of amflutizole, methyl 4-amino-3-phenylisothiazole-5-carboxylate (CHNOS) was assumed to be capable of forming polymorphic structures. Noncentrosymmetric and centrosymmetric polymorphs have been obtained by crystallization from a series of more volatile solvents and from denser tetrachloromethane, respectively. Identical conformations of the molecule are found in both structures.

Conformational polymorphs of 3-cyclopropyl-5-(3-methyl-[1,2,4]triazolo[4,3-a]pyridin-7-yl)-1,2,4-oxadiazole.

The dipharmacophore compound 3-cyclopropyl-5-(3-methyl-[1,2,4]triazolo[4,3-a]pyridin-7-yl)-1,2,4-oxadiazole, CHNO, was studied on the assumption of its potential biological activity. Two polymorphic forms differ in both their molecular and crystal structures. The monoclinic polymorphic form was crystallized from more volatile solvents and contains a conformer with a higher relative energy.

Novel Microwave-Assisted Method of Y2Ti2O7 Powder Synthesis.

In the paper, a novel technique for highly dispersed pyrochlore YTiO is proposed. The experimental results proved that the application of microwave irradiation at a certain stage of calcination allowed synthesizing of YTiO in much shorter time, which ensured substantial energy savings. An increase up to 98 wt.

WAYS TO IMPROVE THE SYSTEM OF MEDICAL PROVIDING OF PUPILS IN UKRAINE.

Objective: The aim: Of this article was analysis of the existing health care system for school-age children in Ukraine and the identification of ways to improve and develop the school health care system like a topical issue of pediatrics.

Patients And Methods: Materials and methods: The analysis of the state of health of children in Ukraine, the questionnaire of the participants of the educational process regarding the expedient and expected types of medical care, the WHO publications on the medical provision of schoolchildren were analyzed.

Conclusion: Conclusions: The analysis of the legal framework in Ukraine in the period of reforming the medical sector has allowed to identify the problematic issues, the solution of which will contribute to ensuring the quality of the medical aid system for school-age children, improving the level of health, shaping the health behavior of health behavior.

"You're nobody without a piece of paper:" visibility, the state, and access to services among women who use drugs in Ukraine.

In Ukraine, women constitute a third of all new HIV infections, and injection drug use accounts for nearly half of HIV infections among women. Women who use drugs (WWUD) often have diminished access to drug use treatment, HIV care, and other health and social services or underutilize women-specific services such as maternal health services. While interpersonal and contextual factors diminish access to and utilization of services among WWUD, rules, processes, and bureaucratic structures also systematically exclude women from accessing services and resources.

MoonProt 3.0: an update of the moonlighting proteins database.

MoonProt 3.0 (http://moonlightingproteins.org) is an updated open-access database storing expert-curated annotations for moonlighting proteins.

Structure of the Diphtheria Toxin at Acidic pH: Implications for the Conformational Switching of the Translocation Domain.

Diphtheria toxin, an exotoxin secreted by that causes disease in humans by inhibiting protein synthesis, enters the cell via receptor-mediated endocytosis. The subsequent endosomal acidification triggers a series of conformational changes, resulting in the refolding and membrane insertion of the translocation (T-)domain and ultimately leading to the translocation of the catalytic domain into the cytoplasm. Here, we use X-ray crystallography along with circular dichroism and fluorescence spectroscopy to gain insight into the mechanism of the early stages of pH-dependent conformational transition.

Studies of eosin Y - DNA interaction using a competitive binding assay.

The interaction between xanthene dye eosin Y and double stranded DNA has been studied by spectrophotometry. The conventional titration study does not show the interaction in the eosin Y - DNA system. Therefore, the competitive binding assay was carried out.

Voronoi Polyhedra as a Tool for the Characterization of Inhomogeneous Distribution in 1-Butyl-3-methylimidazolium Cation-Based Ionic Liquids.

The inhomogeneity distribution in four imidazolium-based ionic liquids (ILs) containing the 1-butyl-3-methylimidazolium (Cmim) cation, coupled with tetrafluoroborate (BF), hexafluorophosphate (PF), bis(trifluoromethanesulfonyl)amide (TFSA), and trifluoromethanesulfonate (TfO) anions, was characterized using Voronoi polyhedra. For this purpose, molecular dynamic simulations have been performed on the isothermal-isobaric () ensemble. We checked the ability of the potential models to reproduce the experimental density, heat of vaporization, and transport properties (diffusion and viscosity) of these ionic liquids.

, , ENSURING THE RIGHT TO HEALTH OF STAFF OF THE UNITED NATIONS.

Objective: The aim: Of the study is to characterize the internal acts of the United Nations on the regulation of the right to health of its staff.

Patients And Methods: Materials and methods: Achieving the purpose of the study is ensured due to the analysis of internal acts of the United Nations, doctrinal sources on the issue selected. The methodological basis is a number of special and general methods.

Role of Lifestyle in Neuroplasticity and Neurogenesis in an Aging Brain.

Neuroplasticity is the brain's ability to transform its shape, adapt, and develop a new neuronal connection provided with a new stimulus. The stronger the electrical stimulation, the robust is the transformation. Neurogenesis is a complex process when the new neuronal blast cells present in the dentate gyrus divide in the hippocampus.

Analog of a Quantum Heat Engine Using a Single-Spin Qubit.

A quantum two-level system with periodically modulated energy splitting could provide a minimal universal quantum heat machine. We present the experimental realization and the theoretical description of such a two-level system as an impurity electron spin in a silicon tunnel field-effect transistor. In the incoherent regime, the system can behave analogously to either an Otto heat engine or a refrigerator.

Methyl 5-chloro-4-hy-droxy-2,2-dioxo-1-2λ,1-benzo-thia-zine-3-carboxyl-ate: structure and Hirshfeld surface analysis.

The title compound, CHClNOS, which has potential analgesic activity, crystallizes in space group 2/. The benzo-thia-zine ring system adopts an inter-mediate form between sofa and twist-boat conformations. The coplanarity of the ester substituent to the bicyclic fragment is stabilized by an O-H⋯O intra-molecular hydrogen bond.

Fungal Planet description sheets: 1042-1111.

Novel species of fungi described in this study include those from various countries as follows: , from marine sediment sand. , (incl. gen.

Semi-refined carrageenan promotes generation of reactive oxygen species in leukocytes of rats upon oral exposure but not in vitro.

Aim: To assess the ability of the common food additive E407a (semi-refined carrageenan) to enter leukocytes in vitro and generate reactive oxygen species (ROS) in leukocytes as a whole and granulocytes in particular, both during incubation and in experimental animals.

Methods: ROS production was assessed in leukocytes incubated with E407a for 2 h at the final concentrations of 5 and 10 g/L using the dye 2',7'-dichlorodihydrofluorescein diacetate (HDCFDA), as well as in cells isolated from rats orally exposed to E407a (140 mg/kg of weight) during 2 weeks (n = 8) and control rats (n = 8), by flow cytometry. Carrageenan uptake by leukocytes was estimated by confocal microscopy using incubation of rhodamine B isothiocyanate-labelled carrageenan with leukocyte suspensions.

Effects of semi-refined carrageenan (food additive E407a) on cell membranes of leukocytes assessed in vivo and in vitro.

Aim To assess the impact of semi-refined carrageenan (E407a) on hydrophobic regions of phosphololipid bilayer in cell membranes of leukocytes collected from rats orally administered this food additive and white blood cells incubated with E407a. Methods Fluorescent probes (ortho-hydroxy derivatives of 2,5-diaryl-1,3-oxazole) were used to estimate the state of lipid bilayer in leukocytes obtained from rats orally exposed to the food additive E407a and in white blood cells incubated with E407a. Results No noticeable changes in the physico-chemical properties were observed in the lipid membranes of leukocytes in the region where the probes locate in response to oral intake of semi-refined carrageenan.

Spin-wave spectroscopy of individual ferromagnetic nanodisks.

The increasing demand for nanoscale magnetic devices requires development of 3D magnetic nanostructures. In this regard, focused electron beam induced deposition (FEBID) is a technique of choice for direct-writing of complex nano-architectures with applications in nanomagnetism, magnon spintronics, and superconducting electronics. However, intrinsic properties of nanomagnets are often poorly known and can hardly be assessed by local optical probe techniques.