3 results match your criteria: "V.M. Bekhterev National Medical Research Center Psychiatry and Neurology[Affiliation]"
Altered Sphingolipid Hydrolase Activities and Alpha-Synuclein Level in Late-Onset Schizophrenia.
Metabolites
December 2023
Department of Molecular Genetic and Nanobiological Technologies Research Center, Pavlov First Saint-Petersburg State Medical University, 197022 Saint Petersburg, Russia.
Article Synopsis
- Recent studies suggest that there may be a connection between lysosomal storage disorders (LSDs) and symptoms of schizophrenia (SCZ), indicating that lysosomal dysfunction could play a role in SCZ development.
- The research involved analyzing lysosomal enzyme activities and alpha-synuclein levels in blood samples from patients with late-onset SCZ and comparing them to patients with Parkinson's disease and healthy controls.
- Significant differences were found, including decreased enzyme activity, higher concentrations of certain lysosphingolipids, and genetic variants linked to LSDs in early-onset SCZ patients, which may contribute to understanding the overlap between these conditions.
Aberrant alternative splicing of exon II in peripheral blood lymphocytes of drug-naïve schizophrenic patients.
Heliyon
December 2020
Laboratory of Molecular Human Genetics, Petersburg Nuclear Physics Institute Named by B.P.Konstantinov of National Research Centre "Kurchatov Institute", 1 Microdistrict Orlova roshcha, Leningradskaya Oblast, Gatchina, 188300, Russia.
The aim of the study was to characterize the pattern of transcript isoforms of exon II in lymphocytes of the blood as peripheral biomarkers of schizophrenia development and the effectiveness of antipsychotic therapy. We primarily observed an increase in mRNA levels and elevation of alternative variants in a sample of drug-naïve schizophrenic patients compared to the control group. There was no association of the expression level of transcript isoforms with the effectiveness of the antipsychotic therapy.
View Article and Find Full Text PDFPotential diagnostic markers of olanzapine efficiency for acute psychosis: a focus on peripheral biogenic amines.
BMC Psychiatry
December 2017
Department of Addictions, Department of personalized psychiatry and neurology, V.M. Bekhterev National Medical Research Center Psychiatry and Neurology, ul. Bekhterev, d. 3, Saint-Petersburg, 192019, Russia.
Background: Biomarkers are now widely used in many fields of medicine, and the identification of biomarkers that predict antipsychotic efficacy and adverse reactions is a growing area of psychiatric research. Monoamine molecules of the peripheral bloodstream are possible prospective biomarkers based on a growing body of evidence indicating that they may reflect specific changes in neurotransmitters in the brain. The aim of this study was to detect peripheral biogenic amine indicators of patients with acute psychosis and to test the correlations between the biological measures studied and the psychopathological status of the patients.
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