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Nicotine inhibits cardiac apoptosis induced by lipopolysaccharide in rats.

J Am Coll Cardiol

February 2003

Cardiology Section, Department of Medicine, V.A. San Diego Healthcare System and University of California, 3350 La Jolla Village Drive, San Diego, CA 92161, USA.

Objectives: Apoptosis develops in several heart diseases, but the therapeutic options are limited. It was hypothesized that nicotine, which inhibits apoptosis in several cells, inhibits cardiac apoptosis induced by lipopolysaccharide (LPS).

Background: Over-the-counter nicotine produces sustained levels (10 to 25 ng/ml) that may be antiapoptotic.

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