2 results match your criteria: "V. Ya. Danilevskii Institute of Problems of Endocrine Pathology[Affiliation]"

Morphofunctional changes in the pineal gland during dynamic adaptation to hypothermia.

Neurosci Behav Physiol

May 2003

Chronoendocrinology Laboratory, V. Ya. Danilevskii Institute of Problems of Endocrine Pathology, Ukrainian Academy of Medical Sciences, 10 Artem Street, 61002 Khar'kov-2, Ukraine.

The effects of stress induced by hypothermia (+4 degrees C for 3 h) on the pathways of serotonin metabolism in the pineal gland and on its structure were studied in adult male Wistar rats. These experiments showed that the melatonin-forming function of the epiphysis undergoes phasic changes during adaptation: there was a significant increase during the first 15 min, which was followed by gradual inhibition (to initial by 30 min) and then sharp suppression (at 3 h). Suppression of the functional activity of the pineal gland occurred because of exclusion of a proportion of pinealocytes from the process of active functioning.

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Melatonin in low doses of (0.05 and 0.5 mg/kg) administered to senescent rats in winter and summer inhibited free radical oxidation and LPO.

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