Association Between Multiple Single Nucleotide Polymorphisms in Folate Metabolism Pathway and Breast Cancer Risk in Georgian Women: A Case-Control Study.

Background: The folate metabolism pathway plays an integral part in DNA synthesis, methylation, and repair. Methylenetetrahydrofolate reductase (MTHFR) and methylenetetrahydrofolate dehydrogenase (MTHFD1) are both enzymes that are involved in this pathway, and the single nucleotide polymorphisms (SNPs) in genes coding for them have modulatory effects on DNA expression. This study aimed to investigate the relationship between MTHFR C677T (rs1801133) and MTHFD1 G1958A (rs2236225) polymorphisms and the risk of developing breast cancer in Georgian women.

A case of improved quality of life in a patient with inoperable pancreatic cancer after repeated RFA.

Radiofrequency ablation (RFA) has widespread popularity due to its immune-modulation effects in many cancers. Optimal settings to apply RFA in pancreatic cancer, in which the advanced stage of the tumor at the diagnosis makes various therapeutic approaches fail, are still demanding. We report the case of a patient with unresectable pancreatic cancer in which 3 repetitive RFA has been applied over a period of 3 months.

[EFFECT OF PROPRANOLOL ON CYTOKINE PROFILE IN AN EXPERIMENTAL MODEL OF HUMAN T LYMPHOCYTES (JURKAT CELLS) IN VITRO].

In this research, in order to establish the role of neuroendocrine mechanisms in the processes of immunomodulation, the effect of propranolol on the cytokine profile in an experimental model of human T lymphocytes (Jurkat cells) in vitro was investigated. Jurkat cells were incubated under standard conditions. Stimulation of the Jurkat cells was performed by incubation with Phytohemagglutinin (PHA) (50 μg/ml) in the presence of propanonol (10-4 M) and without it at 370 for 24 hours.

[STUDY OF ANTIVIRAL AND IMMUNECORRECTIVE EFFECTS OF LAZOLEX IN PATIENTS WITH RECURRENT HERPETIC STOMATITIS].

At present, our country continues intensive research to find and introduce into practice new natural medicinal preparations made from ecologically clean endemic plants of Georgia. An example of such studies in the Iveria-Pharma company is the domestic drug Lazolex (extract of the pericarpium of an unripe walnut), which has passed the necessary preclinical tests and began to be used in the clinic as an antiherpetic agent. On healthy volunteers, we found positive immunotropic effects of Lazolex.

[SELECTIVE EFFICACY OF GEORGIAN LEGUME EXTRACTS ON JURKAT AND MDCK CELLS].

The goal of our study was to establish the anti- proapoptotic activity of the common in Georgia crops on the Jurkat and MDCK cells. Extracts of various varieties of beans (Tirkmela, Batumi meadow, Shulavera, Udelebi, as well as green peas, Lens Culinaris lentils, soy beans) were added to the intact or incubated under oxidative stress conditions Jurkat and MDCK cells. Cell viability (apoptosis intensity) was determined by a cell proliferative activity test (MTT test).

HIPEC IN THE MANAGEMENT OF PERITONEAL CARCINOMATOSIS AND POTENTIAL MARKERS OF TREATMENT EFFICIENCY.

Gastric cancer is a major health burden worldwide and is one of the leading causes of cancer deaths. The average 5-year survival rate is less than 20% and prognosis is very dramatic. It remains difficult to cure, primarily because most patients present with advanced.

BIOLOGICAL ACTIVITY OF GREEN TEA EXTRACTS.

The purpose of our study was to determine effects of green tea extracts on the Jurkat cells incubated under oxidative stress conditions. The research was conducted on leukemic human mature T cells (Jurkat cells). For the modelling of oxidative stress 30% hydrogen peroxide (H2O2) (Sigma) (10 μl, 25 μl 50 μl and 100 μl) was added to Jurkat cell suspension with subsequent incubation for 4, 6, 8 and 24 h.

[Treatment for acute respiratory viral infection and influenza in daily clinical practice: Results of the multicenter international observational FLU-EE study].

Purpose: To study the clinical aspects of influenza and acute respiratory viral infection (ARVI) in routine clinical practice, with efficacy and safety of the antiviral therapy evaluation.

Subjects And Methods: In the large multicenter prospective observational study were enrolled 18,946 patients aged 18 to 93 years with previously determined diagnosis of influenza or ARVI from 262 outpatient sites in Russia, Armenia, Moldova and Georgia. According to study design, 3 visits were evaluated.