Papova viruses and recurrent laryngeal papillomatosis.

The pathogenesis of larynx papillomas has been a challenge of medical science for a long time. Both clinical observations and electronmicroscopical examinations have made it possible to establish the viral origin. Final evidence, however, has been achieved only by complicated immunohistochemical investigations.

Investigation of premalignant lesions of larynx epithelium with histoautoradiography and HPV-assay.

The histological evaluation of precancerous alterations of larynx epithelium is, in transitional cases, very difficult. The differentiation of harmless metaplasia, hyperplasia and keratosis from abnormal proliferation depends on the pathologist's training and experience. Fine diagnostic lines separate the different grades of dysplastic epithelial alterations.

Relationship between "dynamic histology" and metastases of laryngeal tumors.

The clinical characteristics of laryngeal cancer, its site and extent, determine the incidence of regional metastases. However, data have also shown that lymph node involvement is influenced by the degree of malignancy of the tumor. In the course of histoautoradiographic processing of 79 laryngeal tumors and a 5-8-year follow-up study of the patients, a correlation between proliferative activity and incidence of metastasis was found.