4,938 results match your criteria: "Uzbekistan; University of Tashkent for Applied Sciences[Affiliation]"

Diagnostic accuracy of hepatitis E virus antibody tests: A comprehensive meta-analysis.

Hepatol Res

November 2024

Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Article Synopsis
  • Hepatitis E virus (HEV) causes around 20 million infections each year, and while PCR is the best diagnostic method, it's costly and complex compared to antibody tests that are more affordable but vary in accuracy based on several factors.
  • A thorough review of literature compared immunoglobulin M (IgM) and immunoglobulin G (IgG) antibody tests to PCR, analyzing data from 8054 blood samples across 21 studies.
  • The study found IgM antibody tests to have 83% sensitivity and 98% specificity, while IgG tests had 74% sensitivity and 89% specificity, indicating that antibody assays can effectively detect HEV when PCR isn't an option, making them useful diagnostic alternatives.
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Fuel cells are recognized as promising alternatives to existing conventional energy systems for a sustainable future. However, the synthesis of efficient and robust platinum (Pt) based catalysts remains a challenge for practical fuel cell applications. Herein, the PtCo/C nanoparticles with about 4.

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Mathematical modeling of infectious diseases and the impact of vaccination strategies.

Math Biosci Eng

September 2024

Department of Mathematics, School of Sciences and Humanities, Nazarbayev University, Qabanbay Batyr Ave 53, Astana 010000, Kazakhstan.

Mathematical modeling plays a crucial role in understanding and combating infectious diseases, offering predictive insights into disease spread and the impact of vaccination strategies. This paper explored the significance of mathematical modeling in epidemic control efforts, focusing on the interplay between vaccination strategies, disease transmission rates, and population immunity. To facilitate meaningful comparisons of vaccination strategies, we maintained a consistent framework by fixing the vaccination capacity to vary from 10 to 100% of the total population.

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A new methacrylate-chitosan based blend and its ZnO containing nanocomposites: Investigation of thermal and biological properties.

Int J Biol Macromol

November 2024

Samarkand State University, Institute of Biochemistry, Department of Organic Synthesis and Bioorganic Chemistry, University blvd-15, Samarkand, Uzbekistan.

Biobased materials are an important step towards a sustainable future. The need for these materials, which stand out in terms of their environmental and economic benefits, is increasing daily. This study includes the production of new bio based nanocomposites containing a blend of biopolymer chitosan (CS) and synthetic polymethacrylate derivative poly(2-oxo-2-(3,4,5-trifluoroanilino)ethyl-2-methylprop-2-enoate)(POTFAMA) and biosynthesized zinc oxide nanoparticles (ZnO NPs) by hydrothermal method.

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Rationale: The objective of the present study is to investigate desorption of low-volatility analytes in Leidenfrost phenomenon-assisted thermal desorption (LPTD).

Methods: LPTD was investigated for 5 μL solutions of 0.03 ppm cocaine or morphine in methanol (sample weight: 0.

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Article Synopsis
  • This study focuses on using a new type of low-carbon binder, called PCG, to stabilize hazardous waste from municipal solid waste incineration (MSWI FA) by enhancing the immobilization of toxic elements like lead and chromium.
  • Experimental findings indicate that the unique properties of PCG improve the structure and effectiveness of the binders, leading to better containment of potentially toxic elements (PTEs) and satisfactory mechanical and leachability properties.
  • The use of PCG binders results in a significant 60% reduction in carbon emissions compared to traditional methods, showcasing both environmental benefits and advancements in hazardous waste treatment techniques.
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Exosomal microRNAs in cancer metastasis: A bridge between tumor micro and macroenvironment.

Pathol Res Pract

November 2024

College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia; School of Pharmacy, Ibn Sina National College for Medical Studies, Jeddah, Saudi Arabia. Electronic address:

Malignant tumors are complicated structures of cancer cells that are constantly in communication with their local and distant environment. Exosomes are released by tumor cells and can facilitate the cell-cell interaction within the local microenvironment and the primary tumor. In fact, exosomes are secreted by both tumor and non-tumor cells, to provide a mutual communication network between cells and their micro- and/or macro-environments.

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Article Synopsis
  • Global childhood cancer survival rates vary based on regional factors, and understanding treatment decisions for advanced cancer in low- and middle-income countries (LMICs) is essential.
  • A study involving pediatric oncologists in LMICs identified multiple contextual factors that influence decisions regarding treatment, including when non-curative options might be considered and how "poor prognosis" is defined.
  • Findings reveal that decision-making practices in LMICs are inconsistent and complicated, highlighting the need for clearer frameworks and further research on the preferences and challenges faced by healthcare professionals in these regions.
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  • - Over the last 30 years, miniaturized percutaneous nephrolithotomy (mPCNL) has gained popularity due to its potential to reduce complications compared to standard procedures, but there's still debate over best practices and management strategies that hinders wider use.
  • - An international panel of urology experts developed a consensus document on mPCNL to provide a comprehensive framework for practice, which included reviewing literature, identifying research gaps, and conducting surveys to gather expert opinions.
  • - The study revealed 58 key questions on mPCNL practices, and consensus was achieved on 30 questions, affirming mPCNL as an effective technique for treating upper urinary tract stones in both adults and children.
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A 50-year-old female from Uzbekistan presented to our emergency department with severe right hip pain and loss of ambulation. Her history included multiple hepatic echinococcal cyst resections. After a fall, she underwent a proximal femur open reduction and internal fixation (ORIF) and revision in Uzbekistan, which revealed broken screws and cystic lesions.

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Introduction: Uzbekistan is one of the 30 countries with the highest tuberculosis (TB) morbidity, accounting for 87% of all cases globally. The incidence of TB in the Republic of Karakalpakstan (RK) remains consistently high in comparison with other regions of Uzbekistan. The incidence rates of TB strongly differ even among the regions within RK.

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Purpose: This study aims to identify clinical similarities and differences between males and females presenting with orbital fracture.

Methods: Patient charts of adult orbital fracture cases diagnosed via computed tomography and referred by a level 1 trauma center to the McGill University Health Centre between August 2015 to January 2018 were examined and analyzed. Clinical parameters included age, sex, mechanism of injury, morphology of orbital fracture, symptoms and examination features, and rates of ocular pathology.

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Article Synopsis
  • Pneumonia is a serious lung infection with symptoms that are hard to quickly differentiate between viral and bacterial types, complicating rapid diagnosis.* -
  • The study introduced a Concatenated CNN model for diagnosing pneumonia that uses fuzzy logic for image enhancement, resulting in improved image quality and better feature extraction for analysis.* -
  • The enhanced CCNN showed impressive classification results, achieving 98.9% accuracy and outperforming traditional methods, highlighting the effectiveness of combining deep learning with advanced image enhancement techniques.*
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Chemical and Biological Characterization of Metabolites from Using Mass Spectrometric and Cell-Based Assays.

Biomolecules

October 2024

Translational Research Center in Oncohaematology, Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.

Article Synopsis
  • A detailed metabolite profiling of a medicinal plant using UHPLC-ESI-MS/MS was performed for the first time, identifying 71 compounds, mostly flavonoids, triterpene glycosides, and ecdysteroids.
  • The compounds schaftoside, 26-hydroxyecdysone, and silviridoside were highlighted as important markers for evaluating preparation quality.
  • The methanol extract demonstrated cytotoxic and Wnt pathway-inhibiting effects against triple-negative breast cancer, identifying 2-Deoxy-20-hydroxyecdysone as potent, while the presence of a hydroxyl group at C-2 in ecdysteroids was linked to reduced cytotoxicity against cancer cells.
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A comparative study of extraction free detection of HBV DNA using sodium dodecyl sulfate, N-lauroylsarcosine sodium salt, and sodium dodecyl benzene sulfonate.

Sci Rep

October 2024

Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami, Hiroshima, 734-8551, Japan.

This study aimed to develop an extraction-free method for quantitative and qualitative detection of HBV DNA compared to traditional nucleic acid extraction. Paired serum and dried blood spot (DBS) samples from 67 HBsAg-positive and 67 HBsAg-negative individuals were included. Two samples with known HBV DNA titers (~ 10 copies/mL) were examined by extraction-free detection using three surfactants (0.

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Article Synopsis
  • The study compares the effectiveness of targeted biopsy plus regional biopsy (TBx + RBx) against the standard approach of targeted biopsy plus systematic biopsy (TBx + SBx) in detecting clinically significant prostate cancer.
  • A meta-analysis of 21 studies showed that TBx + RBx had a similar detection yield of significant prostate cancer compared to TBx + SBx, suggesting that RBx can replace some systematic biopsies.
  • The study identifies limitations such as the retrospective nature of the included studies and variability in how regional biopsy was defined, but overall supports using TBx + RBx for prostate cancer detection.
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The agricultural industry produces a substantial volume of rice straw (RS) annually, highlighting the importance of recycling RS for sustainable materials. However, the poor interfacial compatibility between RS and polymers often leads to drawbacks in their composites, such as water-swelling and limited tensile strength. Here, we propose a novel approach using Ca(OH) that offers several distinct advantages: enhancement of interfacial compatibility, elimination of the need for water washing, and formation of calcified hybrid particles on fiber surfaces by capturing CO from the atmosphere.

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Cell Type-Specific Anti- and Pro-Oxidative Effects of L. Ellagitannins.

Membranes (Basel)

October 2024

Laboratory of Molecular Biophysics, Department of Microbiology and Biotechnology, Faculty of Biology, University of Bialystok, 15-245 Bialystok, Poland.

Pomegranate and its by-products contain a broad spectrum of phytochemicals, such as flavonoids, phenolic acids and tannins, having pleiotropic preventive and prophylactic properties in health disorders related to oxidative stress and microbial contamination. Here, we examined the biological effects of a pomegranate peel ellagitannins-enriched (>90%) extract, PETE. In vitro studies revealed that PETE has a strong antiradical action towards synthetic radicals and biologically relevant ROS surpassing or comparable to that of Trolox.

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Article Synopsis
  • The apple jewel beetle (AJB) is a severe pest threatening apple orchards and wild apple forests in China, particularly in the Xinjiang Uygur Autonomous Region.
  • Global warming is expected to expand the geographical range of the AJB, with forecasts showing suitable regions in China could increase by 1.11-1.34 times by the 2050s and 2070s.
  • Key climatic factors influencing the AJB's distribution include November maximum temperatures and precipitation in January, highlighting the need for urgent monitoring and management to safeguard apple production.
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Aerial light detection and ranging (lidar) has emerged as a powerful technology for mapping urban archaeological landscapes, especially where dense vegetation obscures site visibility. More recently, uncrewed aerial vehicle/drone lidar scanning has markedly improved the resolution of three-dimensional point clouds, allowing for the detection of slight traces of structural features at centimetres of detail across large archaeological sites, a method particularly useful in areas such as mountains, where rapid deposition and erosion irregularly bury and expose archaeological remains. Here we present the results of uncrewed aerial vehicle-lidar surveys in Central Asia, conducted at two recently discovered archaeological sites in southeastern Uzbekistan: Tashbulak and Tugunbulak.

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Objective: To perform a retrospective analysis of the commission forensic medical examinations' data of pediatric profile with identification of defects in health care delivery and establishment of their connection with unfavorable outcome.

Material And Methods: The data of 3854 commission forensic medical examinations performed in the period from 2012 to 2021 regarding the evaluation of quality of health care delivery for children with the establishment of nature and type of defects in health care delivery, determination of disease (injury) outcome, identification of cause-effect relationship between the defect in health care delivery and negative disease (injury) outcome.

Results And Conclusions: Defects in health care delivery were equal 9% in the studied commission forensic medical examinations.

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Tuberculosis (TB) is a highly contagious disease that remains a global concern affecting numerous countries. Kazakhstan has been facing considerable challenges in TB prevention and treatment for decades. This study aims to understand TB transmission dynamics by developing and comparing statistical and deterministic models: Seasonal Autoregressive Integrated Moving Average (SARIMA) and the basic Susceptible-Infected-Recovered (SIR).

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Objective: Evaluation of the effectiveness of Cytoflavin as a neuroprotective therapy for neurological complications in premature newborns with hypoxic-ischemic encephalopathy.

Material And Methods: 56 premature newborns with low body weight were examined. Newborn children, depending on the therapy, were divided into 2 groups: Group I - 32 premature newborns with hypoxic-ischemic encephalopathy; received basic therapy and Cytoflavin; Group II - 24 premature newborns with hypoxic-ischemic encephalopathy; received only basic therapy.

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Objective This study assessed the accuracy of detecting Human Papillomavirus (HPV) DNA in urine samples compared to cervical samples and identified factors associated with HPV DNA positivity in Uzbekistan. Methods A total of 218 paired urine and cervical samples were collected from women in Uzbekistan. HPV DNA was detected using polymerase chain reaction (PCR) with genotyping.

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In this study, we suggested an innovative approach by introducing an Adaptive Exponential Weighted Moving Average (AEWMA) control chart utilizing Variable Sample Size (VSS) under Bayesian methodology. The proposed methodology utilized an integer linear function to dynamically adjust sample sizes according to the AEWMA statistic. Another appealing feature of our adaptive framework is the integration of the smoothing constant of an EWMA chart, which enhances monitoring responsiveness.

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