First-in-human trial of atrial fibrillation ablation using real time tissue optical assessment to predict pulsed field lesion durability.

Background: Loss of bipolar electrograms immediately after pulsed field ablation (PFA) makes lesion durability assessment challenging.

Objective: The aim of this trial (NCT06700226) was to evaluate a novel ablation system that can optically predict lesion durability by detecting structural changes in the tissue during ablation.

Methods: Patients with paroxysmal atrial fibrillation underwent pulmonary vein isolation (PVI) using PFA (AblaView®, MedLumics).

Determination of zinc complexation with an immobilized reagent for the analysis of environmental objects.

Although significant progress has been made in the effective measurement of Zn(II), Аlizarin red S (ARS) was immobilized on polyethylene polyamine-modified polyacrylonitrile (PPF-1) via a new matrix. This approach allows the detection of low levels of Zn(II) ions in various water samples via preconcentrated atomic absorption spectrometry. The use of PPF-1 in a polymer matrix for zinc preconcentration presents several advantages over traditional sorbtion-spectroscopic methods, including reduced cost, high zinc recovery, increased sensitivity, and selectivity.

Unveiling the physicochemical, photocatalytic, antibacterial and antioxidant properties of MWCNT-modified AgO/CuO/ZnO nanocomposites.

Water pollution, oxidative stress and the emergence of multidrug-resistant bacterial strains are significant global threats that require urgent attention to protect human health. Nanocomposites that combine multiple metal oxides with carbon-based materials have garnered significant attention due to their synergistic physicochemical properties and versatile applications in both environmental and biomedical fields. In this context, the present study was aimed at synthesizing a ternary metal-oxide nanocomposite consisting of silver oxide, copper oxide, and zinc oxide (ACZ-NC), along with a multi-walled carbon nanotubes modified ternary metal-oxide nanocomposite (MWCNTs@ACZ-NC).

Burden of undernutrition and its associated factors among children aged 6-59 months: findings from 2016 Ethiopian demographic health survey (EDHS) data.

Background: Despite numerous government nutrition-specific and sensitive interventions, undernutrition (e.g., underweight) remains the major public health concern among under-five-year-old children in Ethiopia.

Lumbar total disk replacement versus microsurgical lumbar discectomy in treatment of radicular and back pain in railway workers: a prospective randomized controlled trial.

Background: Currently, there remains a high percentage of complications after lumbar discectomy, while there is no uniform tactic to prevent their development. Purpose of the study was to compare the clinical efficacy and return to work rate (RWR) after total disk replacement (TDR) and microsurgical lumbar discectomy (MLD) in railway workers with lumbar disk herniation (LDH).

Methods: We randomly assigned 75 patients out of a total of 81 patients, between 25 and 35 years of age who had one level LDH to undergo single-level TDR surgery (group I, n=37) or MLD surgery (group II, n=38) in the L4-L5 or L5-S1 segments.

The Role of Sustainable Social Work in Pro-Environmental Behaviors: A Mediation and Moderation Model.

Purpose: This study seeks to investigate the effectiveness of psychological interventions in promoting pro-environmental behaviors by fostering resilience and self-efficacy in Iranian youth. Additionally, based on social cognitive theory, the research examines the role of sustainable youth social work in moderating these relationships.

Materials And Methods: A cross-sectional design was employed to collect data via a survey from 384 Iranian participants, using validated scales.

A comprehensive dataset and neural network approach for named entity recognition in the Uzbek language.

In this study, the authors presented a dataset for named entity recognition in the Uzbek language. The dataset consists of 2000 sentences and 25,865 words, and the sources were legal documents and hand-crafted sentences annotated using the BIOES scheme. The study is complemented by the fact that the authors demonstrated the applications of the created dataset by training a language model using the CNN + LSTM architecture, which achieves high accuracy in NER tasks, with an F1 score of 90.

Green hydrothermal synthesis of nickel and zinc-doped nickel ferrite nanoparticles using extracts and their biological studies.

Convectional drugs have failed to tackle the increasing public health challenge of Cancer and diabetes. Phytochemical conjugated nanoparticles are providing safer therapeutic alternatives to address this global challenge. Nanoparticles of nickel, iron and zinc are especially useful because of their magnetic properties, abilities to prevent the onset or slow the progression of these diseases.

Removal of cyanobacterial harmful algal blooms (HABs) from contaminated local park lake using mycelial pellets.

Eutrophication and hypereutrophication in lakes foster harmful blue-green algal blooms, which pose a significant threat to the ecological health of freshwater reservoirs. This study investigated the effectiveness of the bio-flocculation approach using the fungus strain BGF4A1 to remove these harmful blooms, specifically targeting cyanobacterial species like PCC-7914. Key flocculation parameters, cyanobacterial concentrations, adsorption kinetics, and pellet morphology were explored in this research.

In Silico design and molecular dynamics analysis of imidazole derivatives as selective cyclooxygenase-2 inhibitors.

Cyclooxygenase-2 (COX-2), a key enzyme in the inflammatory pathway, is the target for various nonsteroidal anti-inflammatory drugs (NSAIDs) and selective inhibitors known as coxibs. This study focuses on the development of novel imidazole derivatives as COX-2 inhibitors, utilizing a Structure-Activity Relationship (SAR) approach to enhance binding affinity and selectivity. Molecular docking was performed using Autodock Vina, revealing binding energies of -6.

Dynamically Cyclic Fe/Fe Active Sites as Electron and Proton-Feeding Centers Boosting CO Photoreduction Powered by Benzyl Alcohol Oxidation.

Solar-driven CO photoreduction holds promise for sustainable fuel and chemical productions, but the complex proton-coupled multi-electron transfer processes and sluggish oxidation half-reaction kinetics substantially hinder its efficiency. Here, we devised a rational catalyst design to address these challenges by fabricating ferrocene carboxylic acid-functionalized CsSbBr nanocrystals (CSB-Fc NCs), which facilitate simultaneous benzyl alcohol oxidation and CO reduction reactions under visible-light irradiation. The synchronized proton-coupled electron transfer processes between the reduction and oxidation half-reactions on CSB-Fc NCs resulted in a 5-fold increase in the CO reduction rate (45.

Overweight, obesity, and cardiovascular disease in heterozygous familial hypercholesterolaemia: the EAS FH Studies Collaboration registry.

Background And Aims: Overweight and obesity are modifiable risk factors for atherosclerotic cardiovascular disease (ASCVD) in the general population, but their prevalence in individuals with heterozygous familial hypercholesterolaemia (HeFH) and whether they confer additional risk of ASCVD independent of LDL cholesterol (LDL-C) remains unclear.

Methods: Cross-sectional analysis was conducted in 35 540 patients with HeFH across 50 countries, in the EAS FH Studies Collaboration registry. Prevalence of World Health Organization-defined body mass index categories was investigated in adults (n = 29 265) and children/adolescents (n = 6275); and their association with prevalent ASCVD.

Insights from DNA Barcodes-Based Phylogenetic Analysis of Medicinal Plants and Estimation of Their Conservation Status: A Case Study in the Tianshan Wild Forest, China.

The Tianshan wild fruit forest region is a vital repository of plant biodiversity, particularly rich in the unique genetic resources of endemic medicinal plants in this ecological niche. However, human activities such as unregulated mining and excessive grazing have led to a significant reduction in the diversity of these medicinal plants. This study represents the first application of DNA barcoding to 101 medicinal plants found in the Tianshan wild fruit forests, using three genetic loci along with morphological identification methods.

Assessing cropping system dynamics over three decades: remote sensing and GIS insights in Murshidabad-Jiaganj Block.

Agriculture is a significant contributor to the country's economic development. We used multiple Landsat images from 1990 to 2021 in the Murshidabad-Jiaganj Block to assess changes in the agricultural system and their underlying causes. The Rabi season saw a 10.

Current status and trend of global research on the pharmacological effects of emodin family: bibliometric study and visual analysis.

Emodin, as a natural active ingredient, has shown great application potential in the fields of medicine, food and cosmetics due to its unique pharmacological effects, such as anti-inflammatory, antioxidant, anti-cancer, etc. In recent years, with the development of science and technology and the increase of people's demand for natural medicine, emodin research has been paid more and more attention by the global scientific research community. The bibliometric analysis of emodin and the construction of knowledge map are still blank.

Realizing an Energy-Dense Potassium Metal Battery at -40 °C via an Integrated Anode-Free and Dual-Ion Strategy.

Potassium (K)-based batteries hold great promise for cryogenic applications owing to the small Stokes radius and weak Lewis acidity of K. Nevertheless, energy-dense (>200 W h kg) K batteries under subzero conditions have seldom been reported. Here, an over 400 W h kg K battery is realized at -40 °C via an anode-free and dual-ion strategy, surpassing these state-of-the-art K batteries and even most Li/Na batteries at low temperatures (LTs).

Structural Similarity in Natural Products Leading to Sample Misidentification: A Case Study of the Bisbenzylisoquinoline Alkaloids Oxyacanthine and Berbamine.

The similar structures of natural compounds and the absence of NMR data for commercial products raise the risk of misidentification. This work reports a case in which purchased samples labeled as "berbamine" from 14 suppliers are oxyacanthine (). The NMR data of all purchased samples were consistent.

Deciphering risk elements: exploring precursors to recoarctation in individuals with aortic coarctation.

Introduction: Coarctation of the aorta (CoA) patients often experience recoarctation, the reoccurrence of aortic narrowing, presenting a considerable clinical challenge.

Aim: This study aims to investigate the triggers or contributing factors associated with the development of recoarctation (reCoA) following the initial repair of CoA.

Material And Methods: The retrospective cohort study includes information about 120 patients, who underwent 4 different types of surgical repairs of coarctation of the aorta through left thoracotomy in the period 2012-2022.

Synthesis, structure, Hirshfeld surface analysis, and molecular docking studies of the cocrystal between the Cu(II) complex of salicylic acid and uncoordinated piracetam.

The cocrystal (or supramolecular complex) between the Cu(II) complex of salicylic acid and uncoordinated piracetam has been synthesized. Its structure is characterized by elemental analysis, FT-IR, UV-Vis spectroscopy, and X-ray crystallography. Spectroscopic methods confirm the formation of the metal complex, while X-ray crystallography establishes the molecular and crystal structure of the obtained compound.

One-quarter of freshwater fauna threatened with extinction.

Freshwater ecosystems are highly biodiverse and important for livelihoods and economic development, but are under substantial stress. To date, comprehensive global assessments of extinction risk have not included any speciose groups primarily living in freshwaters. Consequently, data from predominantly terrestrial tetrapods are used to guide environmental policy and conservation prioritization, whereas recent proposals for target setting in freshwaters use abiotic factors.

First record of the genus Tshernyshev, 2009 (Coleoptera, Malachiidae) from China.

Background: Tshernyshev, 2009 is a small genus belonging to the tribe Malachiini in the family Malachiidae of the order Coleoptera, with six currently known species: (Erichson, 1840) from Central, Eastern and Southern Europe and North Africa; (Abeille de Perrin, 1885) from Central Europe to Central Asia; Ezzatpanah, 2011 from Iran; (Tshernyshev, 2000) from Uzbekistan and Kyrgyzstan; (Medvedev, 1964) from Kazakstan, Russia and Mongolia; (Medvedev, 1964) from Kazakhstan and Turkey.

New Information: In this study, Tshernyshev, 2009 is newly recorded from China upon the discovery of (Medvedev, 1964) from Xinjiang Autonomous Region. The adult morphological characters are re-described in detail with illustrations of external appearance and relevant characters.

Synthesis, crystal structure and Hirshfeld surface analysis of bis-(acetyl-acetonato-κ ,')(2-amino-1-methyl-1-benzimidazole-κ )copper(II).

The title compound, [Cu(CHO)(CHN)], crystallizes in the ortho-rhom-bic space group . In the crystal structure, the Cu ion is coordinated by two acetyl-acetonate ligands and one 2-amino-1-methyl-1-benzimidazole ligand. The crystal structure features intra-molecular N-H⋯O and inter-molecular N-H⋯O hydrogen bonds, which contribute to the overall cohesion of the crystal.

Synthesis, crystal structure, Hirshfeld surface analysis and DFT calculations of the coordination compound tetra-aqua-bis-{2-[(5-methyl-1,3,4-thia-diazol-2-yl)sulfan-yl]acetato-κ}cobalt(II).

A novel coordination compound, [Co()(HO)], was synthesized from aqueous solutions of Co(NO) and the ligand 2-[(5-methyl-1,3,4-thia-diazol-2-yl)sulfan-yl]acetic acid (H, CHNOS). In the monoclinic crystals (space group 2/), the cobalt(II) ion is located about a centre of symmetry and is octa-hedrally coordinated by two anions in a monodentate fashion through carboxyl O atoms and by four water mol-ecules. A relatively strong hydrogen bond between one of the water mol-ecules and the non-coordinating carboxyl-ate O atom consolidates the conformation.