4,938 results match your criteria: "Uzbekistan; University of Tashkent for Applied Sciences[Affiliation]"

Metabolic and Pharmacokinetic Profiling Studies of N, N-Dimethylaniline-Heliamine in Rats by UHPLC-Q-Orbitrap MS/MS.

Molecules

September 2024

State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, CAS Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China.

Article Synopsis
  • Cardiovascular disease is the leading cause of death globally, and DH, a synthetic compound, shows promise as an antiarrhythmic agent despite limited research on its metabolic behavior in rats.
  • This study identifies 16 metabolites of DH and establishes a reliable method for measuring DH levels in rat plasma, focusing on different metabolic processes such as demethylation and glucuronidation.
  • The findings indicate that DH is well-absorbed with significant tissue distribution, having low toxicity and various excretion pathways.
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Researchers have studied instances of power line technical failures, the significant rise in the energy loss index in the line connecting the distribution transformer and consumer meters, and the inability to control unauthorized line connections. New, innovative, and scientific approaches are required to address these issues while enhancing the reliability and efficiency of electricity supply. This study evaluates the reliability of Internet of Things (IoT)-aided remote monitoring systems specifically designed for a low-voltage overhead transmission line.

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The Anti-Vitiligo Effects of Feshurin In Vitro from and the Mechanism of Action.

Pharmaceuticals (Basel)

September 2024

State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China.

Background: Vitiligo is a complex disorder characterized by skin depigmentation; the canonical Wnt signaling pathway that involves -catenin plays a crucial role in promoting the melanin production in melanocytes. Targeted inhibition of the Janus kinase JAK-STAT pathway can effectively diminish the secretion of the chemokine C-X-C motif ligand CXCL10, thereby safeguarding melanocytes. has been applied as a treatment regimen for a long period; however, its use for the treatment of vitiligo has not been previously documented.

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In order to explore the effect of alloying on the microstructures and mechanical properties of AlCoCrFeNi eutectic high-entropy alloys (EHEAs), 0.1, 0.2, and 0.

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Alzheimer's disease (AD) is a prevalent neurodegenerative disorder, impacting millions of individuals worldwide. Among its defining characteristics is the accumulation of senile plaques within the brain's gray matter, formed through the self-assembly of misfolded proteins contributing to the progressive symptoms of AD. This study investigates a polymorphic Aβ fibril under static and oscillating electric fields using molecular dynamics simulation.

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A three-dimensional printable conductive composite dressing for accelerating wound healing under electrical stimulation.

Colloids Surf B Biointerfaces

January 2025

School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China; International Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers of Zhejiang Province, Hangzhou 310018, China. Electronic address:

In this study, a bioink based on poly(vinyl alcohol) (PVA) and κ-carrageenan network was prepared using conductive polymer (PEDOT:PSS) as conducting medium, and (+)-Catechin-loaded mesoporous ZnO (CmZnO) as antibacterial and anti-inflammatory active medium. 3D conductive composite dressing was further fabricated by an extrusion 3D printing technology. Our results showed that the as-obtained composite dressing had suitable conductivity, efficient blood clotting capacity, and good adhesiveness.

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The van der Waals (vdW) heterostructures based on two-dimensional (2D) semiconducting materials have been thoroughly investigated with regard to practical applications. Recent studies on 2D materials have reignited attraction in the p-n junction, with promising potential for applications in both electronics and optoelectronics. 2D materials provide exceptional band structural diversity in p-n junction devices, which is rare in regular bulk semiconductors.

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Structural dyeing has attracted much attention due to its advantages such as environmental friendliness, vivid color, and resistance to fading. Herein, we propose an alternative strategy for fabric coloring based on CuO microspheres. The strong Mie scattering effect of CuO microspheres enables the creation of vibrant structural colors on fabric surfaces.

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A number of new deoxyvasicinone (2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one) and mackinazolinone (6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazolin-11-one) derivatives with aryl substituents at C7/C8 and at C5 are reported. These compounds are rare representatives of their kind and were prepared in high yields by Suzuki-Miyaura cross-coupling reactions between 7-bromo-2,3-dihydro[2,1-b]quinazoline-9-(1H)-one, 5,7-dibromo-2,3-dihydro[2,1-b]quinazoline-9-(1H)-one or 8-bromomackinazolinone and respective arylboronic acids with palladium acetate as the catalyst. The products were characterized spectroscopically and, in addition, by X-ray crystal structure analyses in six cases.

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Article Synopsis
  • Certain species, including strain Chen 4, play key roles as pathogens affecting plants and animals.
  • A comprehensive genome sequencing of strain Chen 4 was performed using advanced sequencing technology, resulting in a genome size of 41.25 Mb and an assembly into 150 contigs.
  • The study identified over 14,000 protein-encoding genes, with a significant number being putative effectors, enhancing resources for research on evolution and plant-host interactions.
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Background: Invasive pulmonary aspergillosis (IPA) typically occurs in immunocompromised individuals. Severe fever with thrombocytopenia syndrome (SFTS) patients are typically characterized by fever, thrombocytopenia, and leukopenia. These patients typically present with dysregulation of cellular and humoral immunity, which may predispose them to IPA.

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Introduction: Amongst low- to middle income countries (LMIC), outdated and poorly documented orthopedic interventions may pose patients at risk for complications, serious adverse events (SAE) and unsatisfactory results, contradicting the World Health Organization's (WHO) Safe Surgery mandates. Use cases of conditions managed inadequately in LMIC environments are necessary to increase awareness of stakeholders and overcome deficiencies in collaboration with high-income countries (HIC).

Materials And Methods: Methodological and clinical experts from the BG Kliniken and the Charité, Berlin, Germany, were invited to investigate established processes for musculoskeletal disorders and injuries in Tashkent, Uzbekistan.

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Modification of natural compounds through biotransformation process by microorganisms and their pharmacological properties.

Fitoterapia

December 2024

State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China. Electronic address:

The biotransformation of natural compounds by fungal microorganisms is a complex biochemical process. Tandem whole-cell biotransformation offers a promising, alternative, and cost-effective method for modifying of bioactive novel compounds. This approach is particularly beneficial for structurally complex natural products that are difficult to be synthesized through traditional synthetic methods.

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The Professional And Linguistic Assessments Board (PLAB) examination and the International English Language Teaching System (IELTS) represent pivotal evaluations for International Medical Graduates (IMGs) aspiring to pursue medical vocations within the United Kingdom. The United Kingdom's National Health Service (NHS) leans significantly upon the expertise of medically trained professionals hailing from abroad, a fact further underscored by the substantial composition of IMGs within its workforce. The prevailing aftermath of the persistent pandemic has magnified the preexisting deficit of medical practitioners in the nation, thereby compounding the existing challenges.

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Financial inclusion is a crucial element of financial development that transmits cheap financial services to provide advantages to entire segments of society and stimulates economic growth. Our investigation evaluates the asymmetric financial inclusion-economic growth nexus in the top 10 financially inclusive Middle East nations (Israel, Oman, Iran, Qatar, Turkey, Saudi Arabia, Bahrain, Egypt, United Arab Emirates, and Kuwait). Earlier studies adopted panel data tools, which yielded typical outcomes on the association between financial inclusion and economic growth despite few economies did not indicate such a link individually.

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Context: The intermolecular interactions of ethyl acetate (EtOAc)-water (HO)/ethanol (EtOH) mixtures were investigated using a combination of Raman spectroscopy and quantum chemical calculations. The computational approach was used to analyze the structure of hydrogen-bonded complexes of ethyl acetate with water/ethanol molecules, based on density functional theory (DFT). The calculated frequencies closely matched the experimental Raman values, with differences being under 4%.

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Article Synopsis
  • * Data was collected from 16 centers, involving 142 patients, where 96.5% were stone-free 24 hours post-surgery, with a significant number achieving grade A (no fragments).
  • * The findings suggest that using FANS-UAS results in excellent safety and efficacy within 24 hours of surgery, with the only notable complication being transient fever in 7% of patients.
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The geometry, electronic structure, and adsorption properties of halogen molecule X(X = F, Cl) on arsenene were investigated using first-principles calculations. The adsorption of molecules was considered at various sites and in various orientations on the pristine arsenene (p-As) surface. Both molecules show chemisorption and the crystal orbital Hamiltonian population (COHP) analysis reveals the formation of strong X-As bonds.

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Article Synopsis
  • * Despite HCV being a risk factor for liver complications in TB patients, current WHO guidelines do not recommend routine HCV testing during MDR-TB treatment, prompting a study within the TB-PRACTECAL trial to explore co-treatment.
  • * Among 552 participants, 4.3% tested positive for HCV, with those on joint treatment showing favorable outcomes, indicating potential benefits in integrating HCV care with MDR-TB management.
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Exosomes are widely recognized for their roles in numerous biological processes and as intercellular communication mediators. Human cancerous and normal cells can both produce massive amounts of exosomes. They are extensively dispersed in tumor-modeling animals' pleural effusions, ascites, and plasma from people with cancer.

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Article Synopsis
  • The EGF receptor (EGFR) signaling pathway is vital for tumor growth and cancer progression, and miRNAs play a key regulatory role in this process.
  • MiRNAs can directly inhibit EGF ligands and target various components involved in EGF signaling, leading to disturbances that promote cancer cell survival and spread.
  • By understanding how miRNAs interact with EGF signaling, there's potential to develop targeted therapies that could enhance cancer treatment outcomes and tackle issues like therapeutic resistance.
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The current work is the first ever report on the functionalization of CoO nanoparticles (NPs) using the bio active constituents of Abies pindrow Royle (A.pindrow) leaves. An efficient phytochemical extraction method was determined by comparing different extraction strategies for extracting the biologically active compounds of A.

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Anti-thymocyte globulin (ATG) forms an essential component of conditioning in hematopoietic stem cell transplantation (HSCT). Due to the shift of donor preference to alternate donors, reliance on rabbit-ATG (rATG) has increased. Two different forms of rATG (Thymoglobuline and Grafalon) are available for clinical use but data to support the use of one over the other is sparse.

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This study aimed to explore the relationships between study variables that directly and indirectly affect students' beliefs and academic adaptation. A measurement tool model was used to assess participants' 'academic adjustment' (academic motivation, academic lifestyle, academic achievement), basic psychological needs factors (autonomy, competence, relatedness), beliefs about assessment factors (benefit for learning, fairness), classroom participation, and students' FLP anxiety. Explanatory factor analysis (EFA) and confirmatory factor analysis (CFA) were employed to validate the questionnaires.

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A study was conducted to examine the effects of two-step fuel injection on a modified four-cylinder engine that was converted from port to direct injection. The primary fuel source utilized was hydrogen-enriched compressed natural gas (HCNG), which replaced the conventional gasoline. In the initial phase of the procedure, compressed natural gas (CNG) was introduced into the intake manifold at a concentration of 10 % by mass, relative to the total fuel mixture.

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