582 results match your criteria: "Uveitis Anterior Granulomatous"

Sarcoidosis is a systemic granulomatous disease with variable ocular involvement. The most common ocular manifestation is uveitis, which can have potentially sight threatening complications such as glaucoma. We present the case of a man in his 30s with sarcoidosis and recurrent anterior uveitis, necessitating surgical intervention to control intraocular pressure and prevent further glaucomatous optic neuropathy progression.

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Article Synopsis
  • The study aimed to analyze the patterns and outcomes of uveitis in children through a retrospective patient review.
  • A total of 184 pediatric patients were examined, revealing that panuveitis was the most common type, with a significant number displaying non-granulomatous and non-infectious uveitis.
  • After one year, most patients (85.4%) had improved vision, achieving at least 20/40 visual acuity, and Vogt-Koyanagi-Harada disease was identified as the most prevalent specific diagnosis.
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  • Sarcoidosis is an inflammatory disease with various symptoms, and this study focuses on the incidence and prevalence of sarcoidosis-related uveitis, particularly in South Korea, to gather important epidemiological insights.
  • Utilizing a nationwide health database from 2010 to 2019, the research analyzed cases of sarcoidosis and uveitis, examining incidence rates, gender differences, age of diagnosis, treatment patterns, and recurrence types among the patients.
  • The findings revealed that 28.8% of sarcoidosis patients experienced uveitis, mostly recurrent, with anterior uveitis being the most common; the study underscores the necessity for regular eye examinations and tailored treatments for sarcoidosis patients in Korea due to the high
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Purpose: This study aims to elucidate the clinical spectrum of trematode-induced uveitis (TIU), with a particular focus on its bilateral presentation and providing significant insights into its pathophysiology.

Methods: A prospective cross-sectional observational study was conducted at the uveitis outpatient clinic of Mansoura University Ophthalmic Center. The study involved children diagnosed with presumed TIU.

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Multiple sclerosis-associated uveitis in Persian population, a multicenter study.

Mult Scler Relat Disord

December 2024

Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, FL 32611, USA. Electronic address:

Article Synopsis
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Polymerase Chain Reaction for Detection of in Granulomatous Anterior Uveitis - An Analysis of 51 Eyes.

Ocul Immunol Inflamm

October 2024

Director of Uveitis and Ocular Pathology Department, Sankara Nethralaya, Chennai, India.

Purpose: To evaluate the role of polymerase chain reaction (PCR) in detecting in granulomatous anterior uveitis and comparing the results with those of Mantoux test, QuantiFERON-TB Gold test, and High-Resolution Computed Tomography of Chest (HRCT-chest).

Methods: Data of 51 eyes of 38 patients with clinical features of granulomatous anterior uveitis undergoing anterior chamber fluid aspiration for PCR for MTb targeting IS6110 and MPB64 were studied.

Results: Out of 38 patients, 25 (65.

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Article Synopsis
  • The case discusses an unusual instance of epithelial downgrowth (EDG) in a 33-year-old man mistaken for granulomatous uveitis after multiple eye surgeries.
  • The patient experienced symptoms like pain, light sensitivity, and vision loss, with tests ruling out infection, leading to a diagnosis via iris biopsy.
  • Treatment with injections of 5-fluorouracil (5-FU) showed promising results, marking the first documented case of significant reduction of epithelial cell presence due to this therapy.
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Prevalence and risk factors for complicated immuno-mediated uveitis: experience in a tertiary hospital.

Arch Soc Esp Oftalmol (Engl Ed)

December 2024

Unidad de Enfermedades Autoinmunes y Sistémicas, Medicina Interna, Hospital Virgen de las Nieves, Sevilla, Spain.

Article Synopsis
  • The study aimed to examine the characteristics of patients with uveitis and related ocular complications at a tertiary hospital, focusing on identifying risk factors for these complications.
  • A total of 127 patients were reviewed, revealing that a majority were women, with a median age of 51, and 74.2% had an immune-mediated form of uveitis; notable complications included vision loss and various ocular issues such as cataracts and glaucoma.
  • The findings indicated that the number of uveitis outbreaks and being non-Caucasian significantly increased the likelihood of developing ocular complications, suggesting that prompt and accurate diagnosis could improve patient outcomes.*
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Ibrutinib-Related Uveitis in Non-Hodgkin Lymphoma Patients: A Case Report and Literature Review.

Ocul Immunol Inflamm

October 2024

Ophthalmology Interest Group, Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Institute of Translational Medicine (IMT), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.

Purpose: To report two cases of ibrutinib-related uveitis and review the literature to date.

Methods: We report two cases of ibrutinib-related uveitis using CARE guidelines and review the cases reported in the literature.

Results: Case 1) A 55-year-old female with recurrent primary central nervous system lymphoma presented with bilateral decreased visual acuity, photophobia, and floaters that started one month after initiating oral treatment with ibrutinib.

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Purpose: The Hydrus microstent was approved by the FDA in August 2018 for use with cataract surgery to reduce IOP in patients with mild to moderate primary open angle glaucoma (POAG). Pivotal clinical trials demonstrated its overall safety and efficacy in lowering IOP. However, malpositioning of the implant can result in uveitis-glaucoma-hyphema (UGH) syndrome necessitating device explantation.

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Severe Intraocular Inflammation After Intravitreal Injection of Faricimab: A Single-Site Case Series of Six Patients.

Am J Ophthalmol

January 2025

From the Ophthalmology Department (I.B.G., P-H.G., M.S., L-A.S., L.A., C.C-G.), University Hospital, Dijon, France; Eye and Nutrition Research Group (P-H.G., C.C-G.), CSGA, UMR1324 INRAE, 6265 CNRS, Dijon, France.

Purpose: To describe the patient characteristics and clinical course of severe intraocular inflammation (IOI) following intravitreal injection (IVT) of faricimab.

Design: Retrospective case series.

Methods: Case series at a single French academic center (Dijon University Hospital) where 263 patients were treated with faricimab IVT between January 9, 2024 and May 7, 2024.

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Paenibacillus lautus: A new foe in endogenous endophthalmitis.

Retin Cases Brief Rep

August 2024

SNSC Clinical Laboratory Services, Medical Research Foundation, Sankara Nethralaya, 41, College Road, Chennai -600006, Tamil Nadu, India.

Purpose: To discuss the diagnosis and management of a rare case of endogenous endophthalmitis (EE) caused by Paenibacillus lautus mimicking granulomatous uveitis in a child, highlighting the use of 16S rRNA gene amplicon sequencing as an accurate method to identify rare pathogens.

Method: A retrospective chart review of the clinical presentation, microbiologic workup-including microscopy, culture, antibiotic susceptibility, and polymerase chain reaction for pathogen DNA of clinical samples-and the clinical management of the case were recorded.

Result: A 13-year-old boy presented with decreased vision in the right eye for one month.

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Management of JIA associated uveitis.

Best Pract Res Clin Rheumatol

September 2024

Department of Paediatric Rheumatology, Bristol Royal Hospital for Children, Bristol, UK; Translational Health Science, University of Bristol, Bristol, UK. Electronic address:

Article Synopsis
  • Juvenile Idiopathic Arthritis (JIA) is a common chronic childhood condition that can lead to uveitis in 20-25% of cases, requiring regular screening for early detection.
  • Uveitis is typically chronic, asymptomatic, and involves inflammation in the front part of the eye, making collaboration between paediatric rheumatologists and ophthalmologists essential for effective management.
  • Treatment usually begins with methotrexate, and if ineffective, may progress to adalimumab, with alternative options like anti-IL6 and anti-TNF agents available for persistent cases, though evidence for these is limited.
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Introduction: Zoledronate is a commonly prescribed medication to maintain bone health; however, a rare side effect includes ocular inflammation. We report a case of simultaneous anterior uveitis and orbital inflammation associated with zoledronate infusion in a patient with metastatic breast cancer. We also performed a literature search to provide an up-to-date summary of cases with zoledronate-associated ocular inflammation.

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A 35-year-old gentleman came to the ophthalmology outpatient department with complaints of bilateral ocular pain, redness and photophobia since three weeks with similar prior history. The patient was a diagnosed case of systemic sarcoidosis since two years with pulmonary, dermatological and neurological involvement for which he was already on treatment which included oral immunosuppressants, steroids, anticonvulsants and multivitamins. On examination, the best corrected visual acuity was 6/18 in the right eye and 6/12 in the left eye.

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Article Synopsis
  • The text discusses the potential risks associated with the timing of intravitreal anti-VEGF injections and COVID-19 vaccinations, particularly concerning ocular inflammation.
  • A case study is presented involving a 74-year-old man who developed acute noninfectious anterior ocular inflammation after receiving a COVID-19 vaccine and an anti-VEGF injection.
  • The patient experienced blurred vision and inflammation in his left eye, but further exams ruled out serious complications, indicating that more awareness about the interaction between these procedures is necessary.
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Aim: The aim of this study was to explore the patterns of pediatric uveitis and the types of ocular complications of uveitis and to determine the possible risk factors associated with visual impairment.

Method: This was a cross-sectional study conducted at Queen Rania Children's Hospital between June 2020 and June 2023. All children diagnosed with uveitis were enrolled in the study.

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Treatment of uveitis and scleritis patients in Malaysia.

Int J Ophthalmol

March 2024

Department of Ophthalmology, Faculty of Medicine and Defence Health, National Defence University of Malaysia, Kuala Lumpur 57000, Malaysia.

Aim: To determine the common causes and visual outcome after treatment among uveitis and scleritis patients.

Methods: This is a retrospective cohort observational study. All consecutive clinical records of patients with newly diagnosed uveitis and scleritis over a 4-year period, from Jan.

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Article Synopsis
  • Vogt-Koyanagi-Harada (VKH) disease is an autoimmune disorder that affects the eyes and can cause vision problems and skin changes like vitiligo (white patches on the skin).
  • It often happens in people with a certain genetic background, especially those from Asian or Hispanic backgrounds.
  • A case of a 40-year-old woman with VKH showed eye pain, vision loss, and vitiligo, along with other symptoms like redness in her eyes and swelling around the optic nerve.
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Autoimmune Liver Disease Associated Uveitis: An Extrahepatic Manifestation or a Polyautoimmunity Phenomenon? Case Reports.

Ocul Immunol Inflamm

November 2024

Ophthalmology Interest Group, Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Institute of Translational Medicine (IMT), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.

Purpose: To report two cases of non-granulomatous unilateral anterior uveitis in two female patients associated with autoimmune liver diseases (ALD), emphasizing the possibility of this rare coexistence as a polyautoimmunity phenomenon.

Case Descriptions: Case 1: An 18-year-old female with a history of congenital renal hypoplasia and metabolic syndrome presented with anterior uveitis in OS and a history of jaundice, blood elevated hepatic enzymes, and cholangioresonance compatible with primary sclerosing cholangitis (PSC). Laboratory work-up for additional autoimmune and infective causes were within normal limits.

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Article Synopsis
  • * The patient's uveitis included severe symptoms like decreased vision and inflammatory changes in both eyes, which did not improve with various standard treatments.
  • * Tocilizumab successfully brought the patient's uveitis into remission and was effective even one year later while on a low dose of prednisone, suggesting its potential as a valuable treatment option for uveitis related to MS.
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Rosai-Dorfman disease is a rare non-Langerhans cell histiocytosis disorder, also known as sinus histiocytosis, with massive lymphadenopathy. Rosai-Dorfman disease is classified into nodal and extranodal diseases. Ocular involvement is one of the common extranodal manifestations; however, uveitis manifestation is infrequent.

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  • * A total of 3,404 patient records were reviewed, showing a mean diagnosis age of 41.1 years, with a majority being women; the most common types of uveitis were unilateral, acute, and non-granulomatous, primarily affecting the anterior segment of the eye.
  • * Findings highlight idiopathic as the leading cause of uveitis, underlining the importance of ongoing research to adapt diagnosis and treatment strategies for these inflammatory eye conditions.
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Targeted therapies for uveitis in spondyloarthritis: A narrative review.

Joint Bone Spine

September 2024

Department of Internal Medicine, Hospices Civils de Lyon, Hôpital Universitaire de la Croix-Rousse, University Claude-Bernard Lyon 1, Lyon, France; Inserm U1290, Research on Healthcare Performance (RESHAPE), University Claude-Bernard Lyon 1, Lyon, France.

Article Synopsis
  • Spondyloarthritis (SpA) is a group of chronic inflammatory joint disorders that can cause acute uveitis, affecting vision with symptoms like pain and redness in the eye.
  • Most patients experience episodes of uveitis but maintain good vision; however, systemic treatments are advised for those with frequent flare-ups or severe complications.
  • Advances in understanding SpA have led to targeted therapies like TNF inhibitors, showing promising results, while other biologics may vary in efficacy, highlighting the need for collaboration among healthcare providers for effective management.
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We report the long-term follow-up of an immunocompetent patient who presented with slowly progressive endogenous endophthalmitis secondary to Streptococcus anginosus. A 46-year-old healthy man presented with a two-month history of right eye iritis. On examination, visual acuity was 20/60 with intraocular pressure of 6 mm Hg.

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