A Comparison of Intrathecal Dexmedetomidine and Fentanyl as Adjuvants to 0.5% Hyperbaric Levobupivacaine for Lower Abdominal Surgeries: A Prospective, Double-Blinded, Randomized Controlled Trial.

Background Due to its affordability and ease of application, the subarachnoid block is the most frequently used method for lower abdominal procedures. Levobupivacaine has an onset of sensory and motor blockade comparable to that of bupivacaine and prolongs the duration of analgesia while facilitating quick recovery from motor block. Fentanyl and dexmedetomidine, when used as additives to intrathecal local anesthetic, can extend the duration of sensory and motor blockade and enhance postoperative analgesia.

Ileocolic Enteroenteric Fistula in Small Bowel Obstruction With Cecum Perforation in the Pediatric Age Group: A Case Report of a Rare Complication.

Enteroenteric fistula in the pediatric age group is an unusual presentation. It can create a diagnostic dilemma for the physician, particularly in the absence of any previous surgery, prolonged abdominal symptoms, or inflammatory bowel disease. The patient is a 10-year-old girl who presented with mild-grade fever, abdominal distension, scanty stool passage, and foul-smelling vomiting for the past 10 days.

A Comparative Study of Nalbuphine, Clonidine, and Dexmedetomidine as Adjuvants to Ropivacaine in Epidural Anesthesia for Lower Limb Surgery.

Background: In epidural anaesthesia, the addition of an adjuvant to local anaesthetics enhances the efficacy, thereby providing increased duration and intensity of blockade in lower limb surgeries. The aim was to compare the efficacy, onset, and duration of sensory and motor blockade; haemodynamic changes; and sedative and analgesic effects of nalbuphine, clonidine, and dexmedetomidine as an adjuvant to ropivacaine in epidural anaesthesia.

Methodology: A prospective, randomised, double-blind study among 90 patients after taking consent was divided into three groups (30 patients each; Group D received 15 ml of 0.

A Comparison of the Efficacy of High-Dose Vitamin C Infusion and Thiamine (Vitamin B1) Infusion in Patients With Sepsis: A Prospective Randomized Controlled Trial.

Background and objective Vitamin C and thiamine possess properties that may mitigate the harmful effects of sepsis. However, there is a dearth of studies in the literature comparing these two vitamins with each other and with a placebo regarding their efficacy against sepsis. This study aimed to investigate the outcomes associated with high-dose infusions of vitamin C and thiamine in septic patients, thereby seeking to contribute valuable insights into the optimal management of sepsis.

as an emerging rare cause of septicemia among neonates and children in Western Uttar Pradesh: A case series.

Background And Purpose: is a recently emerging nosocomial fungal pathogen. Candidemia is the fourth most prevalent cause of bloodstream Infections with mortality rates varying from 5-71%.

Materials And Methods: This was a retrospective study conducted at Uttar Pradesh University of Medical Sciences, Etawah, India, from September 2023 to February 2024.

Comparison of Direct Laryngoscopy With McCoy Blade and BPL Video Laryngoscopy for Intubation in Patients Undergoing Elective Cervical Spine Surgery.

Background: For patients having cervical spine instability, stabilization of the neck is crucial to prevent further damage to the spinal cord, which can make laryngoscopy challenging. Specialized tools like McCoy blade direct laryngoscope (Surgitech, India) and BPL video laryngoscope (BPL Medical Technologies Pvt. Ltd.

A Randomized Study to Compare the Efficacy Between Intranasal and Intravenous Dexmedetomidine for the Removal of Foreign Bodies in the Esophagus at the Cricopharynx Level in Pediatric Patients.

Background: Foreign body (coins, magnets, button batteries, and metallic foreign bodies) ingestion is common and causes significant morbidity and mortality in children aged six months to three years. Endoscopic removal of swallowed foreign substances is widely accepted, but sedation and general anesthesia may be required to alleviate pain and anxiety during the procedure. Dexmedetomidine is used as a sedative, hypnotic, anxiolytic, and analgesic.

Effect of Music Therapy on Anxiety, Stress and Sedative Requirements in Patients Undergoing Lower Limb Orthopedic Surgery Under Spinal Anesthesia: A Randomized Controlled Study.

Background Music therapy is a safe, non-pharmacological way to help reduce anxiety, especially before surgery. It helps to calm the nervous system, promotes relaxation, and offers comfort by blocking outside noise and distracting from pain. This can be helpful in managing preoperative anxiety and symptoms like hypertension and tachycardia.

A Comparative Study of Intrathecal Hyperbaric Bupivacaine With Fentanyl Versus Intrathecal Hyperbaric Bupivacaine With Dexmedetomidine Administered Sequentially for Lower Limb Orthopaedic Surgeries: A Prospective Randomised Double-Blind Study.

Background:  The subarachnoid block is the predominant and relatively safe approach during lower limb orthopaedic operations. When used as an additive to intrathecal local anaesthetic, both fentanyl and dexmedetomidine can extend the duration of sensory and motor blockade and improve postoperative analgesia.

Objectives:  The objective of this study is to assess and compare the efficacy of sequential administration of fentanyl and dexmedetomidine alongside 0.

Bilateral Traumatic Rupture of the Quadriceps Tendon - A Case Report.

Introduction: Quadriceps tendon rupture is a traumatic injury where the quadriceps detaches from the patella, disrupting the knee's extensor mechanism. Bilateral ruptures, first documented in 1949, are rare, with an incidence of 0.17-2.

Brachytherapy With Modified Rotte-y Applicator for Inoperable Endometrial Cancer: A Case Report.

The preferred treatment for medically inoperable early-stage endometrial cancer (EC) is definitive radiation therapy (RT), either in the form of brachytherapy (BT) alone or in combination with external beam radiotherapy (EBRT). This case report details a modified brachytherapy approach for a 59-year-old female patient who was known to have multiple comorbidities, poor performance status, and progressive slowness in activities of daily living. She presented with a complaint of post-menopausal bleeding per vaginum, for which she underwent investigations and was diagnosed with a case of endometrial adenocarcinoma, International Federation of Gynecology and Obstetrics (FIGO) stage IA and grade I.

Obesity Awareness and Sensitization in Schools for Improving Weight Control and Reducing Obesity Stigma in Students: A Pilot Study.

Introduction: The prevalence of obesity is increasing rapidly in the world, including India. Since obesity is a risk factor for many diseases, the prevalence of obesity-related diseases is also increasing, resulting in decreased productivity and increased disease-related expenses, causing economic loss at the individual, family, and national levels. Government funds that could be utilized for national growth are channeled into the treatment of non-communicable diseases (NCDs).

Role of Genetically Modified Microorganisms for Effective Elimination of Heavy Metals.

Heavy metals are lethal and hazardous pollutants for the ecosystem owing to their virtues including acute toxicity, prolonged persistence, and bioaccumulation. These contaminants are not only a threat to aquatic/terrestrial biota but also pose serious health issues to humans. Natural and anthropologic processes consistently upsurge heavy metal concentration beyond acceptable limits and mobilization and hence disturb biogeochemical cycles and the food chain, although several conventional strategies including adsorption, chemical precipitation, ion exchange, and membrane separation methods are being employed for the removal of these lethal heavy metals from the ecosystem but failed due to lower efficiency rates and high application charges.

Transforming cancer treatment: The potential of nanonutraceuticals.

Chemotherapy in the management of cancer is constrained by limitations like off-target effects, poor bioavailability, and dose-dependent toxicity. Nutraceuticals have been explored as an innovative strategy to overcome chemotherapy drawbacks.However, the clinical utility of nutraceuticals is restricted due to their complex structures, less water solubility, reduced stability, decreased bioavailability and more obstacles in the gastrointestinal tract.

Pathogen-Directed Antimicrobial Stewardship Audit Rounds: Evaluation of an Objectively Planned, Clinical Microbiology-Driven Antimicrobial Stewardship Approach to Influence Antimicrobial Prescriptions of Prescribers.

Introduction: Correct and prompt antimicrobial prescription modifications by the treating team based on the culture and antimicrobial susceptibility test (AST) reports are crucial. Pathogen-directed antimicrobial stewardship (PD-AMS) audit rounds are a clinical microbiology-driven approach to combine prompt appropriate patient management goals with goals of preventing irrational and improper use of antimicrobials.

Methods: The study was a prospective before-after interventional study to evaluate the effectiveness of PD-AMS audit rounds in modifying antimicrobial usage by prescribers on an individual patient basis.

AI in Clinical Trials and Drug Development: Challenges and Potential Advancements.

Artificial intelligence (AI) is one of the fastest-growing fields in various industries, including engineering, architecture, medical and clinical research, aerospace, and others. AI, which is a combination of machine learning (ML), deep learning (DL), and human intelligence (HI), is revolutionizing drug discovery and development by making it more cost-effective and efficient. It is also being used in fields such as medicinal chemistry, molecular and cell biology, pharmacology, pharmacokinetics, formulation development, and toxicology.

"Revolutionizing auricular seroma treatment: exploring diverse surgical strategies with a comprehensive case study".

Auricular seromas present a significant therapeutic challenge due to their propensity for recurrence and potential for cosmetic deformity. This case series illustrates the effective management of post-traumatic auricular seromas through diverse surgical approaches in two patients. Each case highlights the use of different splinting materials post-surgery, detailing the clinical presentations, surgical interventions, and follow-up outcomes.