17 results match your criteria: "Utsunomiya Social Insurance Hospital[Affiliation]"

Article Synopsis
  • Renal fibrosis is a condition that leads to reduced kidney function, and currently, there are no established therapies to prevent it.
  • The study investigated the impact of knocking down a specific protein (Smad4) using targeted small interfering RNAs (siRNAs) in mice with renal fibrosis induced by folic acid.
  • Results showed that Smad4-siRNAs effectively reduced the expression of Smad4 and inhibited the progression of renal fibrosis, suggesting that targeting Smad4 could be a potential therapeutic strategy.
View Article and Find Full Text PDF

Background: A new Japanese histologic classification (JHC) of immunoglobulin A nephropathy (IgAN) for prediction of long-term prognosis was proposed in 2013. The goal of this study was to validate the JHC system in a Japanese single-center cohort.

Methods: A retrospective study was conducted in 198 Japanese adult patients with IgAN.

View Article and Find Full Text PDF

Background: We investigated the practice of exercise counseling of primary care physicians in metabolic syndromes and cardiovascular diseases and its association with their age class, specialty, work place, and their own exercise habits.

Subjects And Methods: The subjects were 3,310 medical doctors who had graduated from Jichi Medical University in Japan. The study instrument was a self-administered questionnaire to investigate their age class, specialty, workplace, exercise habits, and exercise counseling for their patients.

View Article and Find Full Text PDF

The renin-angiotensin-aldosterone system (RAAS) blockers have been widely used in chronic kidney disease patients undergoing hemodialysis; however, whether RAAS blockers have beneficial effects for cardiovascular disease in those patients has not been fully defined. This review focuses on the effects of RAAS blockers in chronic kidney disease undergoing hemodialysis for cardiovascular disease.

View Article and Find Full Text PDF

The prevalence rate for Fabry disease is conventionally considered to be 1 case in 40,000; however, due to increased screening accuracy, reports now suggest that prevalence is 1 case in 1,500 among male children, and it is likely that the clinical importance of the condition will increase in the future. In dialysis patients to date, prevalence rates are between 0.16 and 1.

View Article and Find Full Text PDF

We evaluated the validity of the SOFT COAG electrosurgical output system for the treatment of spontaneous pneumothorax. From April 2008 to May 2010, we compared 64 patients who had undergone bullae resection using endoscopic linear staplers, to 20 patients subjected to electroablation of the bullae using the SOFT COAG output system. There was no significant difference between the 2 groups in terms of operation time, bleeding, and mean duration of postoperative chest tube drainage.

View Article and Find Full Text PDF

To date, there are very few clinical reports that have compared the effects of ezetimibe on lipid parameters between hypercholesterolemic patients with and without type 2 diabetes mellitus (T2DM). In this study, we recruited patients for hypercholesterolemic groups with T2DM (n = 42; men/women = 24/18; HbA1c = 6.7 ± 5.

View Article and Find Full Text PDF

Unsuspected tracheal web inhibits endotracheal intubation: report of a case.

J Anesth

February 2010

Department of General Thoracic Surgery, Utsunomiya Social Insurance Hospital, 11-17 Minamitakasagotyo, Utsunomiya, Tochigi, 321-0143, Japan.

A 66-year-old woman was scheduled for resection of a recurrent brain astrocytoma. During anesthesia induction, endotracheal intubation became impossible. Urgent bronchoscopy under laryngeal mask ventilation visualized a subglottic web 1 cm below the vocal cords.

View Article and Find Full Text PDF

Stroke is sometimes seen in patients with congestive heart failure (CHF). The factors that best predict incident stroke in hospitalized CHF patients are not well known. We performed this pilot study to explore the clinical markers of incident stroke in CHF patients.

View Article and Find Full Text PDF

A 26-year-old woman presented with high fever, marked supraclavicular lymphadenopathy, and morbilliform eruptions and was diagnosed with Kikuchi's disease (KD) based on pathologic findings from biopsied lymph nodes. All her manifestations of KD improved, however, without any specific treatment. The picture of transient morbilliform eruptions typified in KD here is seldom shown in the literature.

View Article and Find Full Text PDF

Cardiac toxicity of 5-fluorouracil (5-FU) has been rarely reported. We encountered a case of angina attack caused by 5-FU. A 58-year-old Japanese woman underwent sigmoidectomy for a sigmoid colon carcinoma with multiple liver metastases.

View Article and Find Full Text PDF

Pleural gas gangrene secondary to esophageal injury by an ingested fish bone.

Jpn J Thorac Cardiovasc Surg

April 2002

Department of Thoracic Surgery and Pulmonary Medicine, Jichi Medical School, Utsunomiya Social Insurance Hospital, Tochigi, Japan.

We report a 73-year-old woman with right pleural gas gangrene, treated successfully by thoracoscopic debridement. The clinical course and chest computed radiography and thoracoscopy findings suggested that her condition resulted from a relatively rare esophageal injury after she accidentally ingested a fish bone. Video-assisted thoracoscopic intervention has proved useful in cases involving pleural gas gangrene.

View Article and Find Full Text PDF

A 74-year-old man developed Cushing's syndrome and hypokalemia due to ACTH-independent bilateral macronodular adrenocortical hyperplasia (AIMAH) with excessive secretion of mineralocorticoid hormones. Plasma concentrations of weak mineralocorticoids were high. The increase in plasma cortisol did not have a diurnal rhythm, and was not suppressed by a high dose of dexamethasone.

View Article and Find Full Text PDF