Steep Glacier Bed Knickpoints Mitigate Inland Thinning in Greenland.

Greenland's outlet glaciers have been a leading source of mass loss and accompanying sea-level rise from the Greenland Ice Sheet (GrIS) over the last 25 years. The dynamic component of outlet glacier mass loss depends on both the ice flux through the terminus and the inland extent of glacier thinning, initiated at the ice-ocean interface. Here, we find limits to the inland spread of thinning that initiates at glacier termini for 141 ocean-terminating outlet glaciers around the GrIS.

Flow-to-Friction Transition in Simulated Calcite Gouge: Experiments and Microphysical Modeling.

A (micro)physical understanding of the transition from frictional sliding to plastic or viscous flow has long been a challenge for earthquake cycle modeling. We have conducted ring-shear deformation experiments on layers of simulated calcite fault gouge under conditions close to the frictional-to-viscous transition previously established in this material. Constant velocity () and -stepping tests were performed, at 550°C, employing slip rates covering almost 6 orders of magnitude (0.

Recovery from multi-millennial natural coastal hypoxia in the Stockholm Archipelago, Baltic Sea, terminated by modern human activity.

Enhanced nutrient input and warming have led to the development of low oxygen (hypoxia) in coastal waters globally. For many coastal areas, insight into redox conditions prior to human impact is lacking. Here, we reconstructed bottom water redox conditions and sea surface temperatures (SSTs) for the coastal Stockholm Archipelago over the past 3000 yr.

Spatial Effects of Livestock Farming on Human Infections With Shiga Toxin-Producing O157 in Small but Densely Populated Regions: The Case of the Netherlands.

The role of environmental transmission of typically foodborne pathogens like Shiga toxin-producing (STEC) O157 is increasingly recognized. To gain more insights into spatially restricted risk factors that play a role in this transmission, we assessed the spatial association between sporadic STEC O157 human infections and the exposure to livestock (i.e.

Neonatal carnitine concentrations in relation to gestational age and weight.

Background: Free carnitine has been measured in the Dutch newborn screening (NBS) program since 2007 with a referral threshold of ≤5 μmol/L, regardless of gestational age or birthweight. However, several studies suggest that carnitine concentrations may depend on gestational age and birthweight. We evaluated differences in postnatal day-to-day carnitine concentrations in newborns based on gestational age (GA) and/or weight for GA (WfGA).

An Assessment of Earth's Climate Sensitivity Using Multiple Lines of Evidence.

We assess evidence relevant to Earth's equilibrium climate sensitivity per doubling of atmospheric CO, characterized by an effective sensitivity . This evidence includes feedback process understanding, the historical climate record, and the paleoclimate record. An value lower than 2 K is difficult to reconcile with any of the three lines of evidence.

Fast and furious: Early differences in growth rate drive short-term plant dominance and exclusion under eutrophication.

The reduction of plant diversity following eutrophication threatens many ecosystems worldwide. Yet, the mechanisms by which species are lost following nutrient enrichment are still not completely understood, nor are the details of when such mechanisms act during the growing season, which hampers understanding and the development of mitigation strategies.Using a common garden competition experiment, we found that early-season differences in growth rates among five perennial grass species measured in monoculture predicted short-term competitive dominance in pairwise combinations and that the proportion of variance explained was particularly greater under a fertilization treatment.

A landscape-scale assessment of the relationship between grassland functioning, community diversity, and functional traits.

Livestock farmers rely on a high and stable grassland productivity for fodder production to sustain their livelihoods. Future drought events related to climate change, however, threaten grassland functionality in many regions across the globe. The introduction of sustainable grassland management could buffer these negative effects.

Nucleation of Stick-Slip Instability Within a Large-Scale Experimental Fault: Effects of Stress Heterogeneities Due to Loading and Gouge Layer Compaction.

Geodetic observations and large-scale laboratory experiments show that seismic instability is preceded by slow slip within a finite nucleation zone. In laboratory experiments rupture nucleation is studied mostly using bare (rock) interfaces, whereas upper crustal faults are typically filled with gouge. To investigate effects of gouge on rupture nucleation, we performed a biaxial shearing experiment on a 350 mm long saw-cut fault filled with gypsum gouge, at room temperature and a minimum horizontal stress  = 0.

Community-level interactions between plants and soil biota during range expansion.

Plant species that expand their range in response to current climate change will encounter soil communities that may hinder, allow or even facilitate plant performance. It has been shown repeatedly for plant species originating from other continents that these plants are less hampered by soil communities from the new than from the original range. However, information about the interactions between intra-continental range expanders and soil communities is sparse, especially at community level.

Ocean Alkalinity, Buffering and Biogeochemical Processes.

Alkalinity, the excess of proton acceptors over donors, plays a major role in ocean chemistry, in buffering and in calcium carbonate precipitation and dissolution. Understanding alkalinity dynamics is pivotal to quantify ocean carbon dioxide uptake during times of global change. Here we review ocean alkalinity and its role in ocean buffering as well as the biogeochemical processes governing alkalinity and pH in the ocean.

Accepting Muslim minority practices: A case of discriminatory or normative intolerance?

West European societies have seen strong debates about the acceptance of Muslim minority practices. In the current research we sought to better understand intolerance by examining whether people use a double standard in which the same practices are tolerated of Christians but not of Muslims (discriminatory intolerance), or rather reject the practices independently of the religious minority group because these are considered to contradict society's normative ways of life (normative intolerance). The results of two survey-embedded experiments among native Dutch were most in agreement with an interpretation in terms of normative intolerance rather than discriminatory intolerance.

Future Transboundary Water Stress and Its Drivers Under Climate Change: A Global Study.

Various transboundary river basins are facing increased pressure on water resources in near future. However, little is known ab out the future drivers globally, namely, changes in natural local runoff and natural inflows from upstream parts of a basin, as well as local and upstream water consumption. Here we use an ensemble of four global hydrological models forced by five global climate models and the latest greenhouse-gas concentration (RCP) and socioeconomic pathway (SSP) scenarios to assess the impact of these drivers on transboundary water stress in the past and future.

Healing Behavior of Simulated Fault Gouges From the Groningen Gas Field and Implications for Induced Fault Reactivation.

We investigated the frictional strength recovery (healing) and subsequent reactivation and slip-weakening behavior of simulated fault gouges derived from key stratigraphic units in the seismogenic Groningen gas field (N. E. Netherlands).

Microphysical Model Predictions of Fault Restrengthening Under Room-Humidity and Hydrothermal Conditions: From Logarithmic to Power-Law Healing.

The maximum fault strength and rate of interseismic fault strengthening ("healing") are of great interest to earthquake hazard assessment studies, as they directly relate to event magnitude and recurrence time. Previous laboratory studies have revealed two distinct frictional healing behaviors, referred to as Dieterich-type and non-Dieterich-type healing. These are characterized by, respectively, log-linear and power-law increase in the strength change with time.

Influence of Barotropic Tidal Currents on Transport and Accumulation of Floating Microplastics in the Global Open Ocean.

Floating plastic debris is an increasing source of pollution in the world's oceans. Numerical simulations using models of ocean currents give insight into the transport and distribution of microplastics in the oceans, but most simulations do not account for the oscillating flow caused by global barotropic tides. Here, we investigate the influence of barotropic tidal currents on the transport and accumulation of floating microplastics, by numerically simulating the advection of virtual plastic particles released all over the world's oceans and tracking these for 13 years.

Small vessel disease lesion type and brain atrophy: The role of co-occurring amyloid.

Introduction: It is unknown whether different types of small vessel disease (SVD), differentially relate to brain atrophy and if co-occurring Alzheimer's disease pathology affects this relation.

Methods: In 725 memory clinic patients with SVD (mean age 67 ± 8 years, 48% female) we compared brain volumes of those with moderate/severe white matter hyperintensities (WMHs; n = 326), lacunes (n = 132) and cerebral microbleeds (n = 321) to a reference group with mild WMHs (n = 197), also considering cerebrospinal fluid (CSF) amyloid status in a subset of patients (n = 488).

Results: WMHs and lacunes, but not cerebral microbleeds, were associated with smaller gray matter (GM) volumes.

Sex differences in flow cytometry-based platelet reactivity in stable outpatients suspected of myocardial ischemia.

Background: Antiplatelet therapy is the mainstay of secondary prevention of cardiovascular events. Studies suggest that women do not obtain equal therapeutic benefit from antiplatelet therapy compared with men. The link between sex differences in platelet biology and response to antiplatelet therapies is unclear.

Learning health care systems: Highly needed but challenging.

Background: Learning health care systems (LHSs) have the potential to transform health care. However, this transformation process faces significant challenges.

Materials And Methods: Based on proposals and early examples of LHSs in the literature and conceptual analysis of the LHS mission, we provide four models with distinct organizational and ethical implications that may facilitate the transformation.

Inpatient prescribing of dual antiplatelet therapy according to the guidelines: a prospective intervention study.

Background: In dual antiplatelet therapy (DAPT), low-dose acetylsalicylic acid is combined with a P2Y12 inhibitor. However, combining antithrombotic agents increases the risk of bleeding. Guidelines on DAPT recommend using this combination for a limited period of between three weeks and 30 months.

Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma.

Targeted inhibition of the c-Jun N-terminal kinases (JNKs) has shown therapeutic potential in intrahepatic cholangiocarcinoma (CCA)-related tumorigenesis. However, the cell-type-specific role and mechanisms triggered by JNK in liver parenchymal cells during CCA remain largely unknown. Here, we aimed to investigate the relevance of JNK1 and JNK2 function in hepatocytes in two different models of experimental carcinogenesis, the dethylnitrosamine (DEN) model and in nuclear factor kappa B essential modulator (NEMO) mice, focusing on liver damage, cell death, compensatory proliferation, fibrogenesis, and tumor development.

Sex Differences in Cardiovascular Medication Prescription in Primary Care: A Systematic Review and Meta-Analysis.

Background Sex differences in the management of cardiovascular disease have been reported in secondary care. We conducted a systematic review with meta-analysis of systematically investigated sex differences in cardiovascular medication prescription among patients at high risk or with established cardiovascular disease in primary care. Methods and Results PubMed and Embase were searched between 2000 and 2019 for observational studies reporting on the sex-specific prevalence of aspirin, statins, and antihypertensive medication prescription, including beta blockers, calcium channel blockers, angiotensin-converting enzyme inhibitors, and diuretics, in primary care.