Safety and biodegradability of a synthetic dural sealant patch (Liqoseal) in a porcine cranial model.

Background: Liqoseal consists of a watertight layer of poly(ester)ether urethane and an adhesive layer containing polyethylene glycol--hydroxysuccinimide (PEG-NHS). It is designed to prevent cerebrospinal fluid (CSF) leakage after intradural surgery. This study assessed the safety and biodegradability of Liqoseal in a porcine craniotomy model.

Is Blood Pressure Lowering in the Very Elderly With Previous Stroke Associated With a Higher Risk of Adverse Events?

Background We investigated whether blood pressure lowering for secondary prevention is associated with a reduction in recurrent stroke risk and/or a higher risk of adverse events in very elderly compared with younger trial participants. Methods and Results This is a random effects meta-analysis of randomized controlled trials of blood pressure lowering for secondary stroke prevention to evaluate age-stratified (<80, ≥80 years) risk of adverse events. Ovid-MEDLINE was searched for trials between 1970 and 2020.

Hepatitis C virus in hemophilia: Health-related quality of life after successful treatment in the sixth Hemophilia in the Netherlands study.

Introduction: Persons with hemophilia and hepatitis C virus (HCV) infection have a lower health-related quality of life (HRQoL) than those never HCV infected. However, it is unknown whether HRQoL after HCV eradication is comparable to individuals never HCV infected. We aimed to compare HRQoL between HCV-cured and never chronically HCV-infected persons with hemophilia.

Generic PROMIS item banks in adults with hemophilia for patient-reported outcome assessment: Feasibility, measurement properties, and relevance.

Background: Legacy hemophilia-specific questionnaires are considered too long, show floor-/ceiling effects, and/or include irrelevant questions. Patient Reported Outcomes Measurement Information System (PROMIS) item banks, including Computer Adaptive Tests (CATs) and short forms, were designed for more efficient outcome assessment.

Objectives: Evaluate the feasibility, measurement properties, and relevance of seven PROMIS CATs and two short forms in patients with hemophilia.

To what extent do home care nurses feel free to assess the care that is needed for their patients? A nationwide survey in the Netherlands.

Background And Aims: Patients receiving nursing care at home require a needs assessment. There are indications that practice variation exists in needs assessments performed by Dutch home care nurses. One possible cause is that nurses are differentially influenced by others when performing needs assessments.

Decline of unique Pontocaspian biodiversity in the Black Sea Basin: A review.

The unique aquatic Pontocaspian (PC) biota of the Black Sea Basin (BSB) is in decline. The lack of detailed knowledge on the status and trends of species, populations, and communities hampers a thorough risk assessment and precludes effective conservation. This paper reviews PC biodiversity trends in the BSB (Bulgaria, Romania, Moldova, Ukraine, and Russia) using endemic mollusks as a model group.

The impact of emotional signals on credibility assessment.

Fake news is considered one of the main threats of our society. The aim of fake news is usually to confuse readers and trigger intense emotions to them in an attempt to be spread through social networks. Even though recent studies have explored the effectiveness of different linguistic patterns for fake news detection, the role of emotional signals has not yet been explored.

Comparing the space-time patterns of high-risk areas in different waves of COVID-19 in Hong Kong.

This study compares the space-time patterns and characteristics of high-risk areas of COVID-19 transmission in Hong Kong between January 23 and April 14 (the first and second waves) and between July 6 and August 29 (the third wave). Using space-time scan statistics and the contact tracing data of individual confirmed cases, we detect the clusters of residences of, and places visited by, both imported and local cases. We also identify the built-environment and demographic characteristics of the high-risk areas during different waves of COVID-19.

Coupled dynamics of iron, manganese, and phosphorus in brackish coastal sediments populated by cable bacteria.

Coastal waters worldwide suffer from increased eutrophication and seasonal bottom water hypoxia. Here, we assess the dynamics of iron (Fe), manganese (Mn), and phosphorus (P) in sediments of the eutrophic, brackish Gulf of Finland populated by cable bacteria. At sites where bottom waters are oxic in spring, surface enrichments of Fe and Mn oxides and high abundances of cable bacteria were observed in sediments upon sampling in early summer.

A perspective on the initiative to develop a multi-species histopathology series.

This perspective summarizes the genesis, development, and potential future directions of the multispecies histopathology series.

A comprehensive tool box for large animal studies of intervertebral disc degeneration.

Preclinical studies involving large animal models aim to recapitulate the clinical situation as much as possible and bridge the gap from benchtop to bedside. To date, studies investigating intervertebral disc (IVD) degeneration and regeneration in large animal models have utilized a wide spectrum of methodologies for outcome evaluation. This paper aims to consolidate available knowledge, expertise, and experience in large animal preclinical models of IVD degeneration to create a comprehensive tool box of anatomical and functional outcomes.

Multi-year observations of the high mountain water cycle in the Langtang catchment, Central Himalaya.

The Langtang catchment is a high mountain, third order catchment in the Gandaki basin in the Central Himalaya (28.2°N, 85.5°E), that eventually drains into the Ganges.

Single Particle Multipole Expansions From Micromagnetic Tomography.

Micromagnetic tomography aims at reconstructing large numbers of individual magnetizations of magnetic particles from combining high-resolution magnetic scanning techniques with micro X-ray computed tomography (microCT). Previous work demonstrated that dipole moments can be robustly inferred, and mathematical analysis showed that the potential field of each particle is uniquely determined. Here, we describe a mathematical procedure to recover higher orders of the magnetic potential of the individual magnetic particles in terms of their spherical harmonic expansions (SHE).

Seismic Slip-Pulse Experiments Simulate Induced Earthquake Rupture in the Groningen Gas Field.

Rock materials show dramatic dynamic weakening in large-displacement (m), high-velocity (∼1 m/s) friction experiments, providing a mechanism for the generation of large, natural earthquakes. However, whether such weakening occurs during induced M3-4 earthquakes (dm displacements) is unknown. We performed rotary-shear experiments on simulated fault gouges prepared from the source-, reservoir- and caprock formations present in the seismogenic Groningen gas field (Netherlands).

Density dependence of daily activity in three ungulate species.

Daily activity in herbivores reflects a balance between finding food and safety. The safety-in-numbers theory predicts that living in higher population densities increases safety, which should affect this balance. High-density populations are thus expected to show a more even distribution of activity-that is, spread-and higher activity levels across the day.

A β-hairpin epitope as novel structural requirement for protein arginine rhamnosylation.

For canonical asparagine glycosylation, the primary amino acid sequence that directs glycosylation at specific asparagine residues is well-established. Here we reveal that a recently discovered bacterial enzyme EarP, that transfers rhamnose to a specific arginine residue in its acceptor protein EF-P, specifically recognizes a β-hairpin loop. Notably, while the rhamnosyltransferase activity of EarP is abolished when presented with linear substrate peptide sequences derived from EF-P, the enzyme readily glycosylates the same sequence in a cyclized β-hairpin mimic.

Dynamics of antibodies to SARS-CoV-2 in convalescent plasma donors.

Objectives: Characterisation of the human antibody response to SARS-CoV-2 infection is vital for serosurveillance purposes and for treatment options such as transfusion with convalescent plasma or immunoglobulin products derived from convalescent plasma. In this study, we longitudinally and quantitatively analysed antibody responses in RT-PCR-positive SARS-CoV-2 convalescent adults during the first 250 days after onset of symptoms.

Methods: We measured antibody responses to the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein and the nucleocapsid protein in 844 longitudinal samples from 151 RT-PCR-positive SARS-CoV-2 convalescent adults.

Microphysical Modeling of Carbonate Fault Friction at Slip Rates Spanning the Full Seismic Cycle.

Laboratory studies suggest that seismogenic rupture on faults in carbonate terrains can be explained by a transition from high friction, at low sliding velocities (), to low friction due to rapid dynamic weakening as seismic slip velocities are approached. However, consensus on the controlling physical processes is lacking. We previously proposed a microphysically based model (the "Chen-Niemeijer-Spiers" [CNS] model) that accounts for the (rate-and-state) frictional behavior of carbonate fault gouges seen at low velocities characteristic of rupture nucleation.

Unwillingness to participate in health checks for cardiometabolic diseases: A survey among primary health care patients in five European countries.

Background And Aims: Since cardiometabolic diseases (CMD) are a frequent cause of death worldwide, preventive strategies are needed. Recruiting adults for a health check could facilitate the identification of individuals at risk for CMD. For successful results, participation is crucial.

Loose programming of GIS workflows with geo-analytical concepts.

Loose programming enables analysts to program with concepts instead of procedural code. Data transformations are left underspecified, leaving out procedural details and exploiting knowledge about the applicability of functions to data types. To synthesize workflows of high quality for a geo-analytical task, the semantic type system needs to reflect knowledge of geographic information systems (GIS) at a level that is deep enough to capture geo-analytical concepts and intentions, yet shallow enough to generalize over GIS implementations.

Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses.

Maternal milk is nature's first functional food. It plays a crucial role in the development of the infant's gastrointestinal (GI) tract and the immune system. Extracellular vesicles (EVs) are a heterogeneous population of lipid bilayer enclosed vesicles released by cells for intercellular communication and are a component of milk.

Automatic quantification of lymphocyte vacuolization in peripheral blood smears of patients with Batten's disease (CLN3 disease).

Quantifying lymphocyte vacuolization in peripheral blood smears (PBSs) serves as a measure for disease severity in CLN3 disease-a lysosomal storage disorder of childhood-onset. However, thus far quantification methods are based on labor-intensive manual assessment of PBSs. As machine learning techniques like convolutional neural networks (CNNs) have been deployed quite successfully in detecting pathological features in PBSs, we explored whether these techniques could be utilized to automate quantification of lymphocyte vacuolization.

Laboratory Measurements of the Wave-Induced Motion of Plastic Particles: Influence of Wave Period, Plastic Size and Plastic Density.

The transport of plastic particles from inland sources to the oceans garbage patches occurs trough coastal regions where the transport processes depend highly on wave-induced motions. In this study, experimental measurements of the plastic particles wave-induced Lagrangian drift in intermediate water depth are presented investigating the influence of the wave conditions, particle size and density on the motion of relatively large plastic particles. A large influence of the particle density is observed causing particles to float or sink for relative densities lower and larger than water respectively.