1,293 results match your criteria: "Utility of Bone Markers in Osteoporosis"
Extract of Ameliorates Postmenopausal Osteoporosis by Promoting Osteoblast Proliferation and Differentiation.
Cells
December 2024
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei 230032, China.
Postmenopausal osteoporosis (PMOP) is a bone disease characterized by bone thinning and an increased risk of fractures due to estrogen deficiency. Current PMOP therapies often result in adverse side effects. The traditional medicinal plant is commonly used to strengthen bones and support kidney function, but its role in treating PMOP is not well understood.
View Article and Find Full Text PDFHealth implications of racial differences in serum growth differentiation factor levels among men with obesity.
Physiol Rep
December 2024
Division of Endocrinology Diabetes and Metabolism at Baylor College of Medicine, Houston, Texas, USA.
Article Synopsis
- The study examined the role of Growth differentiation factor (GDF15) in relation to health markers in obese men of different racial and ethnic backgrounds.
- It involved 193 participants and assessed various health metrics including body composition, hormonal levels, and bone mineral density.
- Findings indicated that GDF15 levels were higher in non-African Americans than in African Americans, and its relations to glucometabolic status and body composition varied by ethnicity, highlighting potential racial differences in health risks.
The impact of creatine levels on musculoskeletal health in the elderly: a mendelian randomization analysis.
BMC Musculoskelet Disord
December 2024
Department of Clinical Laboratory, Jiaxing Maternity and Children Health Care Hospital, Jiaxing University, Jiaxing, China.
Background: Musculoskeletal health among the elderly emerges as a pivotal public health concern against the backdrop of a globally aging population. Creatine, popular within fitness circles, has emerged as a subject of scientific inquiry for its potential benefits on elderly' musculoskeletal well-being. Despite extensive documentation of its effects on athletic performance, investigations into creatine's long-term contributions to the musculoskeletal health of the elderly are comparatively limited.
View Article and Find Full Text PDFS6K/FLNC/ITGβ3 signaling pathway regulates osteoclastogenesis and the inhibition of osteoclastogenesis by columbianadin.
Phytomedicine
November 2024
Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, PR China; State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, PR China. Electronic address:
Article Synopsis
- - The study investigates the effects of Columbianadin (CBN), a compound from traditional medicine, on inhibiting osteoclastogenesis, which contributes to bone loss, and seeks to identify its underlying mechanisms.
- - Researchers used transcriptomics, RT-PCR, Western blot analysis, and proteomics to uncover changes in gene expression during osteoclast differentiation, focusing on the S6K/FLNC/ITGβ3 signaling pathway.
- - Results showed that CBN significantly reduced FLNC levels, which in turn decreased markers of osteoclast differentiation and bone resorption in ovariectomized mice, suggesting CBN could be a therapeutic option for bone-related disorders.
Association of obstructive sleep apnea with bone metabolism in older adults: a hospital-based study.
BMC Musculoskelet Disord
November 2024
Department of Geriatrics, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.
Article Synopsis
- This study explores how obstructive sleep apnea (OSA) impacts bone mineral density (BMD) and bone turnover markers (BTMs) in older adults.
- Researchers analyzed data from 260 participants, categorizing them based on the severity of their OSA and measuring BMD through dual-energy x-ray absorptiometry.
- Findings indicate that OSA is linked to higher BMD in certain areas of the body, but this relationship varies with body mass index (BMI) and specific BTMs, suggesting complex interactions between OSA, bone health, and body composition.
Serum IL-6 and TGF-β1 concentrations as diagnostic biomarkers in elderly male patients with osteoporosis.
Eur Spine J
November 2024
Department of Orthopedics, The People's Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Xinmin Road 2, Danyang, 212300, China.
Article Synopsis
- - The study assesses how serum levels of IL-6 and TGF-β1 relate to bone density and turnover in elderly male patients with osteoporosis, using data from 335 men aged 60 and older.
- - Results indicate that higher IL-6 levels are linked to lower bone density, while higher TGF-β1 levels correlate with better bone density; both markers significantly aid in diagnosing osteoporosis.
- - Key findings suggest that smoking, IL-6, and a specific bone turnover marker are risk factors for osteoporosis, while elevated TGF-β1 and bone density measurements provide protective effects.
Evaluating osteopontin levels in pediatric celiac disease: a potential indicator for mucosal atrophy and osteoporosis.
Eur J Pediatr
November 2024
Department of Pediatrics, Division of Pediatric Gastroenterology and Hepatology, Eskisehir Osmangazi University Faculty of Medicine, Meselik, Eskisehir, 26040, Türkiye.
Article Synopsis
- The study investigated the levels of Osteopontin (OPN) in patients diagnosed with Celiac disease (CD) compared to healthy controls, finding higher OPN levels in CD patients.
- It highlighted that OPN levels were significantly elevated in patients with osteoporosis compared to those with normal bone mineral density (BMD).
- The research suggests that serum OPN may be useful in assessing mucosal atrophy and osteoporosis in CD patients, though more research is needed to confirm its clinical significance.
saponins promote osteogenic differentiation of human umbilical cord-derived mesenchymal stem cells via the BMP-SMAD signaling pathway.
Am J Transl Res
October 2024
College of Pharmaceutical Sciences, Gannan Medical University Ganzhou 341000, Jiangxi, China.
Article Synopsis
- - The study investigates the effects of saponins (MOS), a traditional Chinese medicine, on the osteogenic differentiation of human umbilical cord-derived mesenchymal stem cells (HUC-MSCs), suggesting potential benefits for osteoporosis treatment.
- - MOS was found to promote this differentiation in a concentration-dependent manner, enhancing the expression of key osteogenic genes and activating related signaling pathways, including transforming growth factor-β and calcium pathways.
- - The findings reveal that MOS may work by regulating the BMP-SMAD signaling pathway, highlighting its potential as a therapeutic agent for osteoporosis, especially when combined with stem cell therapy.
4-Hydroxynonenal and Fracture Risk in the Community-Dwelling Older People.
Ann Clin Lab Sci
September 2024
Division of Community and Family Medicine, Jichi Medical University, Tochigi, Japan
Article Synopsis
- * Results show that older adults with a high fracture risk (FRAX® score > 15%) have significantly higher 4-HNE levels compared to those with low risk, suggesting a relationship between oxidative stress and bone health.
- * The findings support the idea that 4-HNE could serve as a useful clinical marker to assess fracture risk due to oxidative stress in older individuals.
FOXO1-mTOR pathway in vascular pericyte regulates the formation of type H vessels to control bone metabolism.
J Orthop Translat
November 2024
Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, PR China.
Article Synopsis
- - Aging leads to osteoporosis, a widespread degenerative disease, with type H blood vessels being crucial for both bone and blood vessel formation; their decline in older age is linked to bone loss, but the exact mechanisms are still unclear.
- - A study used various mouse models and techniques like micro-CT scans and histological staining to assess bone structure and type H vessels, along with testing human endothelial cells for vascular functions under different treatments.
- - The research focused on understanding how FOXO1, a protein implicated in aging processes, affects type H vessels and bone health, using methods like gene analysis, pharmacological interventions, and the creation of genetically modified mice.
D-limonene suppresses RANKL-induced osteoclast differentiation and promotes osteoblast activity in-vitro.
Biosci Biotechnol Biochem
November 2024
Agri-pharmacy Group, School of Biomedical Sciences, Faculty of Health, University of Plymouth, Plymouth, UK.
Article Synopsis
- Osteoporosis treatments are usually implemented after fractures occur, so finding preventative methods to lower fracture risk is important.
- D-limonene, a natural compound found in citrus fruits, has shown potential in promoting bone health by enhancing osteoblast activity and suppressing osteoclast formation, largely due to its effects on NFκB.
- The study indicates that limonene not only supports the development of bone-forming cells but also decreases factors that lead to bone loss, suggesting it could be a useful supplement alongside existing osteoporosis treatments.
bioprinted 3D model enhancing osteoblast-to-osteocyte differentiation.
Biofabrication
November 2024
Laboratory of Tribology and System Dynamics,, UMR-CNRS 5513-Ecole Centrale Lyon, Ecully, Auvergne-Rhône-Alpes FR 69134, France.
Article Synopsis
- * The study focuses on developing a bio-printed model that effectively simulates the process of human primary osteoblasts maturing into osteocytes using hydrogels that mimic the mechanical properties of bone tissue.
- * By experimenting with different cross-linking solutions, the researchers found that a hydrogel with a low elastic modulus and specific viscoelastic traits significantly enhanced the differentiation of osteoblasts, as marked by increased enzyme activity and the formation of dendritic structures.
The Monocyte-to-High-Density Lipoprotein Cholesterol Ratio as a Novel Predictor of the Prevalence of Senile Osteoporosis.
Clin Interv Aging
November 2024
Fujian Key Laboratory of Vascular Aging, Department of Geriatrics, Fujian Institute of Geriatrics, Fujian Clinical Research Center for Senile Vascular Aging and Brain Aging, Fujian Medical University Union Hospital, Fuzhou, Fujian, People's Republic of China.
Article Synopsis
- - The study investigates the link between the monocyte-to-high-density lipoprotein ratio (MHR) and osteoporosis in elderly individuals, finding that a lower MHR is associated with a higher risk of developing osteoporosis.
- - An analysis of data from 563 participants aged 70 and older showed significant differences in MHR among various osteoporosis groups, with positive correlations found between MHR and bone mineral density (BMD).
- - The findings suggest that MHR, alongside body mass index (BMI), is an independent risk factor for osteoporosis and could serve as a valuable predictive tool in clinical settings.
Association of hemoglobin-to-red blood cell distribution width ratio and bone mineral density in older adults.
BMC Musculoskelet Disord
October 2024
Department of Orthopedics, the First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Article Synopsis
- This study investigates the relationship between the Hemoglobin-to-Red Cell Distribution Width Ratio (HRR) and Bone Mineral Density (BMD) or osteoporosis in adults over 50, using data from the NHANES database.
- The results revealed that higher HRR is significantly associated with greater femoral BMD and a lower prevalence of osteoporosis, suggesting that a 1-unit increase in HRR significantly reduces osteoporosis risk.
- The findings indicate that HRR could be a useful marker for assessing BMD and osteoporosis risk in older adults, highlighting the importance of maintaining higher HRR levels for osteoporosis prevention.
Associations of Serum Lipid Traits With Fracture and Osteoporosis: A Prospective Cohort Study From the UK Biobank.
J Cachexia Sarcopenia Muscle
December 2024
School of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Background: Previous studies reveal inconsistent associations between serum lipid traits and the risks of fractures and osteoporosis in the general population.
Methods: This prospective cohort study analysed data from 414 302 UK Biobank participants (223 060 women and 191 242 men, aged 37-73 years) with serum lipid measurements: apolipoprotein A (Apo A), apolipoprotein B (Apo B), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and lipoprotein A (Lp(a)). Multivariable Cox proportional hazard models with penalized cubic splines were used to explore potential nonlinear associations of each lipid trait with the risks of fractures and osteoporosis.
Cinobufagin Suppresses Lipid Peroxidation and Inflammation in Osteoporotic Mice by Promoting the Delivery of miR-3102-5p by Macrophage-Derived Exosomes.
Int J Nanomedicine
October 2024
Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Article Synopsis
- Cinobufagin, a compound from toad venom, shows potential in protecting bone health, particularly against osteoporosis, by increasing bone density and mass.
- The study involved testing cinobufagin and its exosomes on ovariectomized mice, revealing significant improvements in bone metrics and reductions in inflammation and oxidative stress.
- Findings suggest that cinobufagin enhances the function of macrophage-derived exosomes, which deliver miR-3102-5p to target the gene alox15, thereby promoting bone formation and inhibiting processes that lead to bone loss.
Biochemical versus radiological screening for osteoporosis in menopause; will Irisin help?
J Pak Med Assoc
October 2024
Department of Human Anatomy, Jabir Ibn Hayyan Medical University, Najaf, Iraq.
Article Synopsis
- - The study aimed to assess the effectiveness of irisin as a diagnostic marker for osteoporosis in post-menopausal women, utilizing a case-control design with a sample size of 142 participants at a hospital in Baghdad.
- - Results showed significant differences in biomarker levels (including serum irisin) between women with osteoporosis and healthy controls, with serum irisin levels correlating positively with bone mineral density and negatively with T-scores.
- - The findings indicated that irisin could serve as a reliable serological marker for osteoporosis, demonstrating 84% sensitivity and 100% specificity at a cut-off value of 31.4 ng/ml.
Iron Deficiency Is Associated with Elevated Parathormone Levels, Low Vitamin D Status, and Risk of Bone Loss in Omnivores and Plant-Based Diet Consumers.
Int J Mol Sci
September 2024
Institute of Food Science, Technology and Nutrition (ICTAN), CSIC, 28040 Madrid, Spain.
Article Synopsis
- - The study involved 297 healthy adults, examining the effects of different diets (omnivore, lacto-ovo vegetarian, vegan) on vitamin D levels and parathormone (PTH) status, revealing a correlation between low vitamin D and high PTH levels.
- - Those with elevated PTH had markers indicating increased bone resorption and remodeling, and lower levels of hematocrit and ferritin, while showing higher serum iron mainly in vegetarians.
- - The findings suggest that low vitamin D and low iron levels are linked to higher PTH and bone resorption, particularly affecting vegetarians, highlighting a potential risk for osteoporosis in postmenopausal women and the elderly.
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing.
Allergol Select
October 2024
Center for Child and Adolescent Health, Helios Hospital Krefeld, Academic Hospital of RWTH Aachen, Krefeld.
Article Synopsis
- Primary atopic disorders (PAD) are rare genetic conditions caused by specific gene variants that affect skin and immune function, making diagnosis challenging among common allergic disease cases.
- Identifying PAD requires recognizing clinical red flags like family history and unusual infections, as conventional lab tests are inadequate for definitive diagnosis.
- Whole-genome sequencing (WGS) enhances diagnostic efficiency and accuracy, but requires careful interpretation and collaboration among specialists to effectively manage PAD cases.
The Effect of Photobiomodulation on Bone Mineral Density, Serum Vitamin D, and Bone Formation Markers in Individuals with Complete Spinal Cord Injuries with Osteoporosis.
Photobiomodul Photomed Laser Surg
November 2024
Poorsina Hospital, Neuroscience Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Article Synopsis
- - A quasi-experimental study tested the effects of photobiomodulation (a type of laser therapy) on bone mineral density (BMD) in eight patients with complete spinal cord injury and osteoporosis, applying the treatment on one side of the body and using the other side as a control.
- - The treatment involved using a specific type of laser at various energy densities based on the bone's depth from the skin and was administered three times weekly for eight weeks, with BMD and vitamin D levels measured at the start, after treatment, and weeks later.
- - Results showed significant BMD improvements in the proximal-femur and forearm regions, along with increased vitamin D levels, although no changes were noted in other areas or
Causes of Musculoskeletal Pain in Paget's Disease of Bone.
Calcif Tissue Int
November 2024
Centre for Genomics and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Article Synopsis
- Paget's disease of bone (PDB) makes bones grow and change shape in a messy way, which can lead to problems like pain, deafness, and broken bones.
- A study with 168 people found that about 73% of them had musculoskeletal pain, mainly because of osteoarthritis in joints away from the PDB affected areas.
- The research showed that pain was more common in older folks and women, and highlighted the need to check each person's pain to treat it correctly.
Multidisciplinary team approach for CKD-associated osteoporosis.
Nephrol Dial Transplant
December 2024
Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska Universitetssjukhuset, Stockholm, Sweden.
Article Synopsis
- * The European Renal Osteodystrophy (EUROD) initiative emphasizes the importance of a multidisciplinary team (MDT) approach, bringing together specialists to tackle complex cases of CKD-associated osteoporosis.
- * The establishment of kidney-bone MDTs is recommended to enhance diagnostics and personalized treatment plans for improve patient management in CKD-MBD across different levels of healthcare.
Assessing fat fraction and R2* value of lumbar spine based on MRI as a marker of bone mineral density.
Br J Radiol
December 2024
Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Objectives: The study aimed to investigate the correlation between fat fraction (FF), R2* value of vertebrae based on IDEAL-IQ sequence and bone mineral density (BMD) based on QCT, and their diagnostic value for low BMD and osteoporosis.
Methods: Subgroups were divided according to different gender, age, BMI, and bone mass to compare the differences in parametric variables. One-way ANOVA, independent samples t-test, correlation coefficient analysis, linear regression analysis, and ROC curve analysis were performed.
The effects and safety of testosterone replacement therapy for men with hypogonadism: the TestES evidence synthesis and economic evaluation.
Health Technol Assess
August 2024
Health Services Research Unit, University of Aberdeen, Aberdeen, UK.
Article Synopsis
- - Low testosterone levels in men lead to hypogonadism, characterized by sexual dysfunction, fatigue, and decreased muscle strength, and testosterone replacement therapy (TRT) is a common treatment despite concerns about its safety and effectiveness on cardiovascular health.
- - The research aimed to investigate the safety and cost-effectiveness of TRT for men with hypogonadism, while also exploring men's personal experiences with the treatment.
- - A systematic review and meta-analysis were conducted, evaluating data from multiple studies, to assess primary outcomes like mortality and cardiovascular events, ultimately creating a model to analyze the economic benefits of TRT in improving quality of life.
Multi-omics Analysis to Identify Key Immune Genes for Osteoporosis based on Machine Learning and Single-cell Analysis.
Orthop Surg
November 2024
Suzhou Medical College of Soochow University, Suzhou, People's Republic of China.
Article Synopsis
- The study investigates osteoporosis, a serious bone disease, focusing on the immune processes involved and aims to identify new diagnostic and treatment strategies using bioinformatics and machine learning techniques.
- Researchers analyzed single-cell and transcriptome data to identify immune cell subpopulations and key genes, sorted osteoporosis samples into subgroups, and measured immune characteristics using various algorithms.
- Results indicated significant increases in certain immune cells in osteoporosis patients and identified specific genes that have altered expression levels in their blood, which could be potential markers for understanding the disease better.