1,251 results match your criteria: "Uterus Smooth Muscle Tumors"

Lipid-laden uterus: Investigating uterine fibroids and lipid association.

Pathol Res Pract

December 2024

Nitte (Deemed To Be University), KS Hegde Medical Academy (KSHEMA), Department of obstetrics and gynecology, India; Nitte (Deemed To Be University), KS Hegde Medical Academy (KSHEMA), KSHEMA IVF Fertility & Reproductive Medicine Centre India, India.

Uterine Fibroids (UF) are the most common (about 70 % cases) benign gynecological smooth muscle tumors of the uterus in women of reproductive age, characterized by abnormal cholesterol, lipoproteins, and triglyceride levels, and are a major public health concern. Despite its high prevalence, this condition remains complex and poorly understood. These tumors are hormone-dependent and hormones and lipid levels are inversely related.

View Article and Find Full Text PDF

Uterine fibroids are benign tumors, arising from uterine smooth muscle cells. They are one of the most common benign tumors of the female genital tract among childbearing women, occurring in 20%-50% of women of reproductive age. The association of uterine myomas with pregnancy is high.

View Article and Find Full Text PDF

We present the first case of low-grade endometrial stromal sarcoma (ESS) invading a leiomyoma, which was difficult to diagnose preoperatively. A 49-year-old multiparous woman was referred to our institution due to the enlargement of an old leiomyoma after menopause. Transvaginal ultrasonography revealed a 40-mm lesion in the myometrium of the uterine body with calcification and edema.

View Article and Find Full Text PDF

Primary pelvic peritoneal masses, not arising from major organs, are uncommon in adults. Leiomyomas are a group of benign smooth muscle tumors, most commonly found in the uterus in premenopausal women (70-80%). Extra-uterine locations are very rare and more frequent in women.

View Article and Find Full Text PDF
Article Synopsis
  • Smooth muscle tumors of the uterus vary from benign leiomyomas to malignant leiomyosarcomas, with STUMP representing a challenging gray area of tumors with uncertain malignant potential.
  • A case study is presented of a 52-year-old woman with severe menorrhagia, diagnosed with STUMP after a hysteroscopy and biopsy, which raised concerns about the possibility of leiomyosarcoma.
  • The patient underwent a radical hysterectomy, where the final diagnosis remained STUMP, and has since been on regular follow-up without any recurrence, highlighting the rarity of STUMP presenting as a uterine polyp.
View Article and Find Full Text PDF
Article Synopsis
  • Leiomyomas are non-cancerous tumors of the uterine smooth muscle that can have various forms and are known to undergo secondary changes, sometimes resembling more serious conditions.
  • A rare type called cotyledonoid dissecting leiomyoma (CDL) can appear as large, abnormal masses, leading to misdiagnosis as cancer due to its size and complexity.
  • The article includes a case study of a 65-year-old woman with CDL, highlighting the need for awareness among healthcare professionals to prevent unnecessary aggressive treatments.
View Article and Find Full Text PDF

Uterine fibroids are benign smooth muscle tumors of the uterus, are relatively common in reproductive-age women, and are associated with increasing maternal age. This case study details a 37-year-old female patient who was incidentally diagnosed with a larger lower segment fibroid during her first pregnancy scan and responded well to treatment, delivered by a cesarian due to transverse lie and lower uterine segment fibroid completely obstructing the birth canal.

View Article and Find Full Text PDF

Ultrasound findings of ovarian intravenous leiomyomatosis: a case report.

Front Oncol

October 2024

Medical Records Statistics Division, Deyang People's Hospital, Deyang, Sichuan, China.

Intravenous leiomyomatosis (IVL), an abnormal growth pattern of uterine leiomyomas, is a rare tumor characterized by masses of smooth muscle cells appearing histologically benign and proliferating within the blood vessels but not invading the tissue. Currently, there have been limited reports of early cases of IVL, and the imaging characteristics of IVL remain uncertain, resulting in frequent misdiagnosis prior to surgery. The present study utilized a case of early IVL detected through conventional ultrasound and subsequently confirmed contrast-enhanced ultrasound (CEUS) to further investigate ultrasound's diagnostic efficacy for early IVL detection.

View Article and Find Full Text PDF

With no more than two dozen cases reported in the literature, malignant peripheral nerve sheath tumor (MPNST) is a rare primary mesenchymal neoplasm arising in the female genital tract. Most cases occurred in middle-aged adults with high grade histology, unfavorable clinical outcome, and no history of neurofibromatosis type 1. Its extreme rarity in this site no doubt poses a diagnostic challenge during routine clinical practice.

View Article and Find Full Text PDF

Introduction Endometrial cancer, one of the most prevalent gynecological malignancies, represents a significant contributor to global mortality and morbidity. The histological subtype of this cancer is pivotal in treatment planning and patient risk stratification. This case series, comprising seven cases, underscores the significance of rare endometrial cancer variants and the importance of ancillary studies, specifically immunohistochemistry, in comprehending and diagnosing the condition.

View Article and Find Full Text PDF
Article Synopsis
  • - Angiomyofibroblastoma (AMFB) is a very rare benign tumor found in the lower genital tract, mainly affecting premenopausal women and usually requires surgical removal.
  • - A unique case involved a 51-year-old woman with breast cancer who had a large pelvic mass, which turned out to be AMFB in the uterus, confirmed through histopathology and immunohistochemical analysis.
  • - This case emphasizes the need for accurate diagnosis of AMFB, as it can mimic other tumors like aggressive angiomyxoma, and suggests potential connections with uterine myomas that need further research.
View Article and Find Full Text PDF

Intravenous Leiomyomatosis of the Uterus: An Intriguing Case Revealed through Anatomopathological Examination.

Tunis Med

October 2024

Emergency Department Maternity and neonatology center of Tunis, Tunis, Tunisia. Faculty of medicine of Tunis, university Tunis el manar Tunisia.

Introduction: Intravenous leiomyomatosis (IVL), a rare type of uterine leiomyoma (its incidence is about 0.25% to 0.40% of patients who present uterine fibroma), is characterized by the formation and growth of benign leiomyoma tissue within the vascular wall or lymphatic lumen.

View Article and Find Full Text PDF
Article Synopsis
  • Uterine fibroids are benign tumors that often lead to symptoms like heavy menstrual bleeding (menorrhagia), which can affect women’s quality of life, particularly in premenopausal women.
  • This study analyzed the relationship between different types of uterine fibroids and the incidence of anemia in patients diagnosed with fibroids between 2016 and 2022.
  • Findings revealed that 75% of women with submucosal fibroids experienced anemia, while subserosal fibroids were linked to the lowest risk, though all fibroid types showed no significant differences in anemia severity.
View Article and Find Full Text PDF

This review focuses on uterine mesenchymal tumors that are defined on a molecular level by a single and unique genetic alteration, that is somehow necessary and sufficient to allow tumor growth and progression. Although diverse from a clinical, morphological and immunohistochemical point of view, the different entities we are going to talk about share both a simple genomic profile with a low number of chromosomal alterations observed by CGH Array (few deletions, gains or amplifications..

View Article and Find Full Text PDF

Direct Effects of Inflammatory Cytokines on Mouse Uterine Contraction.

Am J Reprod Immunol

October 2024

Guangzhou Key Laboratory of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Article Synopsis
  • Uterine contractions are initiated during labor, influenced by pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α, but their direct effects on these contractions have not been thoroughly studied before.
  • The study involved tension recordings and calcium imaging to analyze how these cytokines and LPS affect contractions and calcium activity in mouse uterine smooth muscle cells.
  • Findings indicate that inflammatory cytokines enhance uterine contractions rapidly, and while LPS with TNF-α also boosted contractions, it wasn't statistically significant; overall, cytokines stimulate inflammatory responses, affecting uterine activity during labor.
View Article and Find Full Text PDF

Uterine leiomyomas are a frequent finding in women of reproductive age. However, rare, unusual growth patterns exist, such as atypical, cellular, mitotically active, myxoid, and epithelioid leiomyomas, and present a major concern as they mimic highly malignant uterine tumors such as uterine leiomyosarcomas. An example of such cases is the epithelial type leiomyoma which is the subject of our report in a 35-year-old female.

View Article and Find Full Text PDF
Article Synopsis
  • * A case study of a mid-30s woman highlights a 6-cm pelvic tumor identified via ultrasound (US) and MRI, leading to a hysterectomy that confirmed STUMP through immunohistochemical analysis.
  • * Key imaging features include a well-circumscribed lesion on US, strong signal intensity on T2-weighted and diffusion-weighted MRI, and the importance of early diagnosis for effective treatment management.
View Article and Find Full Text PDF
Article Synopsis
  • * A case study discusses a 28-year-old woman who experienced progressive abdominal swelling and underwent surgery after imaging suggested a cyst; multiple uterine leiomyomas were confirmed through histology.
  • * Detection of abdominal masses that may mimic cysts, especially with characteristics like a pedicle sign, should lead to consideration of subserosal leiomyomas, particularly in young women with no signs of pregnancy or malignancy.
View Article and Find Full Text PDF

Giant "Hydra Headed" Uterine Fibroid in a Nullipara: A Case Report.

Clin Med Insights Case Rep

September 2024

Department of Obstetrics and Gynecology, Bayelsa Medical University, Yenagoa, Bayelsa State, Nigeria.

Background: Uterine fibroids, or Leiomyoma is a type of Smooth Muscle Tumors of the uterus (SMTs) and are common in the black race. Giant uterine fibroids, on the other hand, are uncommon and may occur during patient dissimulation. Dissimulation may occur because of a dread of surgery and hospitals visits, fear of surgical death, chronic intake of herbal concussion, and a religio-traditional strong belief system on instant healing following prayers, among others.

View Article and Find Full Text PDF
Article Synopsis
  • Leiomyomas are rare benign tumors from smooth muscle cells, with pancreatic cases being extremely uncommon, with only 6 known instances before this one.
  • A 21-year-old male presented with unusual symptoms, including jaundice and anemia, leading to the discovery of a mass in the pancreas through advanced imaging techniques.
  • The diagnosis of a low-grade leiomyoma was confirmed through biopsy and surgical removal, underscoring the need to consider such tumors in young patients and advocating for surgical resection as the best treatment option.
View Article and Find Full Text PDF

Low-grade endometrial stromal sarcomas (LGESSs) are indolent tumors with a slow progression rate that tend to recur locally. They represent up to 10% of all primary sarcomas of the uterus and endometrium and only 0.2% of all genital tract tumors.

View Article and Find Full Text PDF

Leiomyosarcoma (LMS) is an extremely rare malignant pathology affecting smooth muscle cells, with the uterus being the predominant location of LMS. Its occurrence in the duodenum is rare, making it a diagnostic challenge for radiologists. Patients with duodenal LMS can present with very vague symptoms such as abdominal discomfort, loss of weight, or manifestations associated with internal gastrointestinal bleeding.

View Article and Find Full Text PDF
Article Synopsis
  • Perivascular epithelioid cell tumor (PEComa) is generally a benign tumor, but this report details two cases of advanced malignant PEComa in women aged 74 and 50, leading to complex surgical management.* -
  • The first patient presented with a large, painful abdominal mass and difficult pathological diagnosis, while the second patient showed typical immunohistochemical patterns and received targeted therapy, resulting in no recurrence after 8 months.* -
  • The study highlights the variability in clinical features of metastatic PEComa and the challenges in diagnosis, noting that there are currently no definitive diagnostic markers for these tumors.*
View Article and Find Full Text PDF

The most common benign neoplastic uterine tumors that grow monoclonally from the smooth muscle cells of the uterus are uterine fibroids or leiomyomas, which may occur as a single lesion or as multiple lesions with variation in size from microscopic to large macroscopic extent. The majority are diagnosed in the preclinical routine reliably, despite challenges due to the possibility of multiple differential diagnoses. Hence, this report highlights a case of a postmenopausal female of 53-year-old working as a staff nurse at the same hospital and who visited the outpatient department of obstetrics and gynecology with chief complaints of pain in the right side of the abdomen for four hours (presentation similar to that of appendicitis).

View Article and Find Full Text PDF

Deep learning based uterine fibroid detection in ultrasound images.

BMC Med Imaging

August 2024

Department of Obstetrics and Gynecology, The Second Hospital of Shanxi Medical University, No. 382, Wuyi Road, Xinghualing District, Taiyuan City, 030001, Shanxi Province, China.

Uterine fibroids are common benign tumors originating from the uterus's smooth muscle layer, often leading to symptoms such as pelvic pain, and reproductive issues. Early detection is crucial to prevent complications such as infertility or the need for invasive treatments like hysterectomy. One of the main challenges in diagnosing uterine fibroids is the lack of specific symptoms, which can mimic other gynecological conditions.

View Article and Find Full Text PDF