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[The types and distributive features of gene mutation on beta-thalassemia in three districts in northwest China].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi

August 1998

Research Institute of Clinical Medicine, Urumqi General Hospital of Lanzhou Command PLA, Urumqi, Xinjiang, 830000 P. R. China.

Objective: To sum up the results of gene analyses on beta-Thalassemia in three districts in northwest China and discuss the types and distributive features of the mutation.

Methods: Polymerase china reaction in combination with dot-blot hybridization of allele-specific oligonucleutide probes(PCR-ASO).

Results: In the gene analysis carried out in 85 probands with beta-Thalassemia, twelve types of gene mutation were identified from five nationalities.

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