339 results match your criteria: "Urothelial Papilloma of the Urinary Bladder"
The Feasibility and Diagnostic Adequacy of PD-L1 Expression Analysis Using the Cytoinclusion Technique in Bladder Cancer: A Prospective Single-Center Study.
J Clin Med
July 2024
Department of Urology, Veneto Institute of Oncology (IOV)-IRCCS, Headquarter of Castelfranco Veneto, 35128 Padua, Italy.
Article Synopsis
- - The study investigates the role of PD-L1 expression as a potential biomarker for bladder cancer by analyzing its presence in urine samples from patients undergoing surgical treatment for the disease.
- - Among 29 patients, PD-L1 expression rates varied significantly across tumor grades, with higher detection in high-grade tumors and good agreement between urine tests (cytoinclusion) and traditional tissue analysis (histopathology).
- - The research suggests cytoinclusion can serve as a promising, non-invasive method for assessing PD-L1 levels, potentially aiding in the diagnosis and prognosis of bladder cancer, and recommends further standardization for clinical use.
Bladder papilloma: A rare benign tumor - Case report and literature review.
Int J Surg Case Rep
July 2024
Department of Urology, Mohamed VI University Hospital, Oujda, Morocco.
Article Synopsis
- * A case study involved a 66-year-old male experiencing hematuria, diagnosed with bladder papilloma after imaging and cystoscopy revealed an echogenic lesion, which was confirmed to be benign post-surgery.
- * Understanding bladder papilloma's symptoms, diagnosis, and management strategies is crucial, especially since it typically appears in younger patients and presents a low risk for recurrence or progression to aggressive cancer.
Quantitative differentiation of non-invasive bladder urothelial carcinoma and inverted papilloma based on CT urography.
BMC Urol
March 2024
Department of Radiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, 1# Banshan East Road, Hangzhou, 310022, China.
Article Synopsis
- The study examines the effectiveness of CT urography (CTU) indicators in distinguishing between bladder urothelial carcinoma (BUC) and inverted papilloma of the bladder (IPB).
- A total of 103 patients' CTU data were analyzed for qualitative and quantitative indicators, leading to the development of a predictive model that helps in diagnosis.
- Key indicators such as junction smoothness, maximum tumor diameter, tumor-wall interface, and arterial reinforcement rate were found to significantly differentiate BUC from IPB, resulting in a high diagnostic accuracy of the combined model (AUC = 0.934).
Urinary Bladder Cancer Induced by N-Butyl-N-(4-Hydroxybutyl)-Nitrosamine.
Methods Mol Biol
January 2024
Faculty of Medicine, Institute of Cell Biology, University of Ljubljana, Ljubljana, Slovenia.
Article Synopsis
- Urinary bladder cancer is the tenth most common cancer globally, primarily characterized by urothelial carcinomas, which can vary in prognosis depending on their type and stage.
- Over half of these cancers are benign papillomas or early-stage papillary urothelial carcinomas (Ta and T1), while more advanced forms like carcinomas in situ (Tis) can lead to high-risk muscle-invasive cancers (T2).
- A major challenge in treating bladder cancer is its high recurrence rate, between 50% and 90%, and researchers utilize the BBN model in rodents to study the disease due to its similarities to human cases, with a protocol provided for effective treatment.
Robot-assisted radical nephroureterectomy for upper urinary tract tumor: initial experience with the use of novel surgical robot system, hinotori.
Transl Cancer Res
December 2023
Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Article Synopsis
- The study explores the initial use of the hinotori surgical robot for robot-assisted radical nephroureterectomy (RANU) in eight patients with upper urinary tract tumors.
- All surgeries were completed without converting to open surgery, and there was no major complications, highlighting the technique's safety and effectiveness.
- Results indicated a median operative time of 230 minutes, minimal blood loss, and a median hospital stay of 8 days, showcasing favorable outcomes despite the small sample size.
RAS Family Gene Mutations, Clinicopathological Features, and Spread Patterns of Inverted Urothelial Papilloma of the Bladder.
Am J Surg Pathol
April 2024
Division of Pathology, The Cancer Institute.
Article Synopsis
- * In a study involving 39 IUP cases, researchers found that 87% had oncogenic mutations in RAS family genes, particularly HRAS, which was linked to smoking and specific morphological traits, while KRAS mutations were only found in non-smokers.
- * The study revealed no cases of recurrence or progression to cancer during follow-up, emphasizing the role of RAS mutations in IUP development and their relationship to different tumor subtypes and spread patterns.
[Significance of TERT promoter mutation in differential diagnosis of non-invasive inverted urothelial lesions of bladder].
Zhonghua Bing Li Xue Za Zhi
December 2023
Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing 100191, China.
Article Synopsis
- - This study analyzes the role of mutations in the TERT promoter gene in different types of inverted urothelial lesions in the bladder, aiming to improve differential diagnosis from 2016 to 2022.
- - A total of 32 patients were examined, revealing no TERT mutations in less aggressive lesions like florid glandular cystitis and inverted urothelial papilloma, while mutation rates increased with malignancy, particularly in nested subtype urothelial carcinoma where all tested cases exhibited mutations.
- - The prevalent mutation types in the cases analyzed were primarily C228T and C250T, indicating that combining tumor morphology with TERT mutation analysis can aid in distinguishing between benign and malignant urothelial lesions.
Young population bladder neoplasms.
Eur Rev Med Pharmacol Sci
November 2023
Department of Pathology, Eskisehir City Hospital, Eskisehir, Turkey.
Article Synopsis
- Bladder urothelial carcinoma mainly affects older individuals, and this study focused on understanding its prognosis and characteristics in patients under 40 years old.
- A total of 17 patients were analyzed, revealing that younger patients typically presented with smaller, low-grade tumors and experienced fewer recurrences compared to older patients.
- The findings suggest that bladder cancer in individuals under 40 tends to be less aggressive, with no instances of tumor progression observed in the young patient group during the study period.
Human amniotic membrane inhibits migration and invasion of muscle-invasive bladder cancer urothelial cells by downregulating the FAK/PI3K/Akt/mTOR signalling pathway.
Sci Rep
November 2023
Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Article Synopsis
- Bladder cancer is a prevalent type of cancer with significant treatment costs, and research is focusing on the human amniotic membrane (hAM) for its potential anticancer benefits.
- Studies show that hAM extracts can inhibit key markers related to cancer progression and migration in bladder cancer cells, indicating a dose-dependent effect on these processes.
- The findings suggest that hAM's ability to downregulate important cancer-related signaling pathways could lead to new therapeutic strategies and support ongoing drug development efforts.
Article Synopsis
- Advanced bladder squamous cell carcinoma (aBSCC) is a rare type of bladder cancer, and researchers studied its genomic alterations (GAs) in relation to human papilloma virus (HPV) status.
- Out of 171 aBSCC samples analyzed, 11 (6.4%) were HPV-positive, predominantly affecting younger women, with significant differences in genomic alterations between HPV+ and HPV- tumors, particularly in mutations related to tumor suppressor genes.
- Notably, markers associated with immunotherapy did not show significant differences between the two groups, and the absence of MTAP loss in HPV+ cases indicates a potential divergence in treatment options.
Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ.
Nat Commun
September 2023
State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institutes of Biomedical Sciences, Human Phenome Institute, Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
Article Synopsis
- The study analyzes 448 samples from 190 patients to understand the complex progression of urothelial bladder cancer (UC) across various stages and grades.
- Proteogenomic findings suggest that HRAS mutations influence signaling pathways that lead to different tumor types, particularly distinguishing between urothelial papilloma and papillary urothelial cancer (PUC).
- Key insights reveal that DNA damage is crucial in carcinoma in situ (CIS) progression, while specific metabolic changes and immune responses differ between PUC and CIS, which could inform future clinical practices.
A retrospective study on expression and clinical significance of PHH3, Ki67 and P53 in bladder exophytic papillary urothelial neoplasms.
PeerJ
July 2023
Department of Clinical Pathology, Weifang Medical University, Weifang, Shandong, China.
Article Synopsis
- Exophytic papillary urothelial neoplasms (EPUN) have varied prognoses and can be hard to diagnose, highlighting the need for better diagnostic markers like PHH3, which reflects mitotic activity in tumors.
- This study assessed PHH3 expression in different types of EPUN (high-grade, low-grade, low malignant potential, and papilloma) and compared it with other proteins, Ki67 and P53, using a sample of 101 cases.
- Findings indicated that PHH3 correlates strongly with mitotic counts and Ki67 across various EPUN types, suggesting its potential role in diagnosing and predicting outcomes for these tumors.
Pneumovesicoscopic management of bladder neoplasms in children: three case reports.
Pediatr Med Chir
July 2023
Pediatric Surgical Unit Salesi Children's Hospital, Ancona; Università Politecnica delle Marche, Ancona.
Article Synopsis
- Urothelial bladder neoplasms (UBN) are rare in children and lack established treatment guidelines, making management difficult.
- Pneumovesicoscopy shows promise as a potential treatment option for some pediatric UBN cases based on its past use in other urological conditions.
- The authors report successful use of pneumovesicoscopy in three pediatric cases, effectively excising a papilloma and biopsying a botryoid rhabdomyosarcoma, highlighting its viability as an alternative technique.
Clinicopathologic Features of Noninvasive Inverted Urothelial Papillary Tumor.
Am J Clin Oncol
September 2023
Department of Pathology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Article Synopsis
- * Researchers analyzed archived tissue samples from patients diagnosed between 2005 and 2020, comparing inverted tumors with traditional types to assess differences in recurrence rates and survival.
- * Findings revealed that inverted tumors have significantly lower recurrence rates, particularly for less aggressive forms, and high disease-free survival rates over 2 and 5 years compared to other tumor types.
Cytomorphologic visualization of circulating tumor cells in urinary bladder cancer patients using ScreenCell™ technology: Potential as a simple cytology test.
Diagn Cytopathol
July 2023
Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Rishikesh, India.
Article Synopsis
- Circulating tumor cells (CTCs) are important for predicting outcomes in solid tumors, but traditional detection methods can be costly and complicated.
- In a study of 24 patients suspected of having Urinary Bladder Cancer, a new, simpler detection method using filtration technology and routine staining was employed to identify CTCs.
- The results indicated that the presence of CTCs is significantly linked to tumor invasion and stage, potentially highlighting their value in diagnosing and predicting the prognosis of urinary bladder cancers, although further research with larger samples is needed.
Invasive urothelial carcinoma with squamous differentiation and associated high-risk human papilloma virus infection: Clinical, cytologic, and histologic features of a rare entity.
Ann Diagn Pathol
April 2023
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address:
Article Synopsis
- The study examines the relationship between Fine Needle Aspiration (FNA) cytology results and histological features of a rare case of high-grade urothelial carcinoma with squamous differentiation linked to high-risk HPV infection.
- A 69-year-old woman presented with urinary issues and was found to have invasive carcinoma after diagnostic procedures, despite minimal prior catheterization.
- The findings highlight the importance of cytopathology in identifying unique cases of cancer, particularly in patients without extensive medical histories typically associated with such lesions.
Dietary Capsaicin Reduces Chemically Induced Rat Urinary Bladder Carcinogenesis.
Plant Foods Hum Nutr
March 2023
Department of Structural and Functional Biology, Bioscience Institute, São Paulo State University (UNESP), Botucatu-SP, Brazil.
Article Synopsis
- Capsaicin (CAP), the compound that gives chili peppers their heat, has potential health benefits, but its safety and effectiveness against cancer development are not fully understood.
- This study investigated the effects of dietary CAP on urothelial lesions caused by the carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in male rats, involving six different treatment groups.
- Results showed that rats consuming 0.02% CAP alongside BBN had a significant reduction in cancerous lesions and related biological markers, indicating that dietary CAP is both safe and may help protect against cancer development.
Clinicopathological analysis of recurrence and progression of low-grade papillary urothelial carcinoma of the urinary bladder: Predicting the outcome.
Ann Diagn Pathol
December 2022
Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA; Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA.
Article Synopsis
- Urothelial carcinoma of the bladder is the most common urinary system cancer, with low-grade variants generally having a low risk of recurrence, although some patients still experience progression to high-grade forms.
- A study analyzed data from patients treated between 2011 and 2021, revealing that 60.9% had no recurrence, while 32.9% experienced at least one recurrence and 6.2% progressed to high-grade cancer.
- Factors linked to recurrence included larger tumor size and multiple lesions at initial diagnosis, with former smokers facing significantly higher risks for both recurrence and progression.
Pediatric Bladder Tumors: A Ten-Year Retrospective Analysis.
Urology
November 2022
Pediatric Urology Associates, P.C. Tarrytown, NY.
Article Synopsis
- This study reviews a 10-year experience at a pediatric urology practice focusing on bladder tumors in children, aiming to enhance the understanding of their presentation and management.
- Researchers analyzed medical records of 30 pediatric patients diagnosed with various types of bladder tumors, excluding those with specific pre-existing bladder conditions, revealing a mix of tumor types and treatment methods used.
- The findings indicate that while pediatric bladder tumors can be aggressive, most identified tumors were benign, and all patients showed no evidence of disease at their latest follow-ups.
High prevalence of p16 staining in malignant tumors.
PLoS One
July 2022
Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Article Synopsis
- * The highest levels of p16 positivity were found in specific cancers like uterine cervix squamous cell carcinomas (94.4%) and Merkel cell carcinoma (97.7%), with all tumor types showing some degree of p16 staining.
- * A significant correlation between p16 positivity and HPV status was identified, with 80.4% of p16 positive squamous cell carcinomas testing HPV positive, suggesting that strong p16 expression can indicate malignancy, although its use
Persistently elevated β-human chorionic gonadotropin level after vacuum-assisted uterine aspiration: a case report.
J Med Case Rep
July 2022
Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
Article Synopsis
- A case study details a 49-year-old woman who experienced elevated β-hCG following an incomplete abortion, leading to an extensive medical work-up that ultimately revealed urothelial carcinoma.
- The findings highlight the importance of considering urologic issues like urothelial carcinoma in patients with elevated β-hCG, especially when they show relevant risk factors, despite it being an uncommon cause.
Histopathologic findings in patients who have undergone blue light cystoscopy and bladder biopsy or transurethral resection: A contemporary clinicopathologic analysis of 100 cases.
Pathol Res Pract
June 2022
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Urology, Emory University School of Medicine, Atlanta, GA 30322, USA; Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA; Department of Pathology, Veterans Affairs Medical Center, Decatur, GA 30033, USA. Electronic address:
Article Synopsis
- Blue light cystoscopy helps urologists detect potentially malignant bladder lesions that standard cystoscopy might miss, but there’s limited research on the accuracy of this method, especially concerning false positives.
- A study from 2017 to 2021 evaluated 100 patients, mostly older men, and found that 69 cases were malignant, prominently high-grade urothelial carcinoma, and 31 were benign lesions, highlighting the mix of findings from the procedure.
- Understanding the correlation between the histopathological results and blue light cystoscopy could be crucial for improving patient management and developing better monitoring strategies for those undergoing this type of examination.
Urothelial Papilloma of the Urinary Bladder: A Case Report and Literature Review of a Rare Entity.
Cureus
February 2022
Pathology, Faculty of Medicine, Al-Azhar University, Cairo, EGY.
Article Synopsis
- Urothelial papilloma is a rare, benign tumor of the bladder identified during a routine ultrasound, which indicated it might be a bladder tumor.
- The tumor was surgically removed using transurethral resection, and the analysis confirmed it was benign with no signs of cancer.
- Despite being benign, there's a risk of recurrence that can happen years later; therefore, long-term monitoring is crucial, and follow-up has shown no signs of recurrence so far.
[Inverted urothelial papilloma of the bladder in an adolescent].
Andes Pediatr
October 2021
Departamento de Cirugía Infantil, Hospital Exequiel González Cortes, Santiago, Chile.
Article Synopsis
- Inverted urothelial papilloma is a rare bladder tumor in kids, and due to its low occurrence, there's no standard management plan.
- A 13-year-old girl was found to have this tumor during a bladder ultrasound, and after removing it, tests confirmed the diagnosis; she has been symptom-free for 3 years after regular check-ups.
- This case emphasizes that inverted papilloma is usually benign and highlights the need for accurate diagnosis to avoid unnecessary treatments, relying instead on non-invasive monitoring.