Effect of fermented soybean on metabolic outcomes, anthropometric indices, and body composition: a systematic review and meta-analysis of clinical trials.

The aim of the current study was to systematically review and quantify the findings of randomized controlled trials (RCTs) assessing the effect of fermented soy products on anthropometric indices, body composition, and metabolic outcomes. PubMed, Scopus, and Web of Science were searched to identify the relevant articles from inception until March 2024. The weighted mean differences (WMD) and corresponding 95% confidence intervals (CI) were calculated as effect sizes and analyzed using the random-effects method.

Aging and voluntary exercise's effects on Aβ1-42 levels, endoplasmic reticulum stress factors, and apoptosis in the hippocampus of old male rats.

Within the aging cortex, amyloid beta peptide (Aβ) is a crucial element of the senile plaques, a hallmark feature often observed in cases of Alzheimer's disease (AD). The UPR (unfolded protein response), a cellular mechanism for protein folding, is switched on by Aβ accumulation. Endoplasmic reticulum (ER) stress has been identified as playing a role in aging and the development of neurodegenerative diseases.

The interactions of spontaneous abortion, dietary intake of selenium, and fat mass and obesity associated (FTO) genotype: a case-control study in Iran.

Background: Spontaneous abortion (SA) is reported to be associated with Fat Mass And Obesity-Associated FTO genotype and dietary intake of selenium. This research assessed the potential interactions between the risk of SA, dietary selenium intake, and the FTO rs9939609 polymorphism.

Methods: This case-control study encompassed 192 women who experienced SA and 347 control participants.

Quantitative evaluation of the canalis sinuosus relative to adjacent structures in cone-beam computed tomography images.

Background: Careful anatomical investigation of canalis sinuosus (CS) is essential to prevent damage to blood vessels and nerves in this area during surgical procedures, such as placing dental implants in the anterior maxillary region. This study investigated the relationship and distance between the CS and its adjacent structures.

Methods: A total of 400 cone-beam computed tomography (CBCT) images of Iranian adults aged 20-86 years were included in this retrospective study.

Effects of acupuncture and foot reflexology on sleep quality in patients with acute lymphoblastic leukemia: A clinical trial.

Background: Sleep disturbances are common among individuals with leukemia, and they can significantly impact their overall well-being. Acupuncture and foot reflexology, two alternative therapies rooted in traditional Chinese medicine, have gained recognition for their potential to address sleep issues and alleviate associated symptoms.

Methods: This single blinded, three-groups randomized controlled trial was navigated at Tohid Hospital, involving 132 leukemia patients divided into acupuncture (n = 44), foot reflexology (n = 44), and control (n = 44) groups via random card selection.

Recent Advances in the Application of Engineered Exosomes from Mesenchymal Stem Cells for Regenerative Medicine.

Exosomes, cell-derived vesicles produced by cells, are fascinating and drawing growing interest in the field of biomedical exploration due to their exceptional properties. There is fascinating evidence that exosomes are involved in major biological processes, including diseases and regeneration. Exosomes from mesenchymal stem cells (MSCs) have shown promising outcomes in regenerative medicine.

Northwest Iranian dermatophyte isolates: anthropophilic and geophilic.

Background And Purposes: The fungi known as dermatophytes are a group of keratinophilic agents responsible for superficial infections in humans and animals. Recognition of the species distribution and epidemiology of dermatophytosis may be helpful in the prevention and improve prophylactic measures. The present molecular epidemiology study sought to investigate the incidence of etiological agents causing dermatophytosis.

Community Involvement in COVID-19 Management: A Central Component of Comprehensive Public Health Responses to COVID-19 and Future Health Crises.

The COVID-19 pandemic is highly contagious, with symptoms such as myalgia, cough, fever, and weakness, posing a greater risk to older adults and individuals with chronic conditions. Effective management requires meaningful community involvement to reduce health inequalities and ensure people-centered health care. Engaging local voices, including leaders, health care professionals, and vulnerable populations, enhances decision-making, transparent communication, and resource mobilization.

Modeling the time series of scorpion stings in Southwestern Iran.

Scorpion stings pose a significant public health concern in Iran, resulting in approximately 45,000-50,000 cases and 19 deaths annually. The Khuzestan and Hormozgan provinces have the highest reported incidence rates, with an estimated 36,000 cases each year. This study focused on modeling the time series data of scorpion stings, specifically in Shoushtar City, from 2017 to 2022.

Effectiveness of different gums on modulating of glycemic indices in adults: a systematic review and meta-analysis.

Background: Functional foods have been widely used as the anti-diabetic agents worldwide. Existing studies presented conflicting results of anti-hyperglycemic properties of gums. This systematic review and meta-analysis study evaluated the existing trials and determined the efficacy of different gums on glycemic indices.

Antibacterial effect of 940 nm diode laser on -infected root canals.

Background: This study compared the antibacterial effects of 940 nm diode laser and sodium hypochlorite and chlorhexidine irrigations on in human permanent single-rooted teeth.

Materials And Methods: In this study, 65 extracted human single-rooted teeth were prepared using the crown-down method using rotary files. The root canals were irrigated with 5.

Assessing patient satisfaction with hemodialysis and peritoneal dialysis care and associated factors in Iran.

Purpose: With the increasing demand for dialysis, there is a growing emphasis on patient-centered care. This study investigated patients' satisfaction levels with peritoneal dialysis (PD) and hemodialysis (HD) care in Iran.

Methods: A cross-sectional multicenter study was conducted among 346 patients with chronic kidney disease (CKD) covered by the Iran Health Insurance Organization who received dialysis services from October to December 2022 across the country.

Exosome-driven nano-immunotherapy: revolutionizing colorectal cancer treatment.

Colorectal cancer (CRC) ranks as the third most common cancer worldwide and remains a major cause of cancer-related deaths, necessitating the development of innovative therapeutic approaches beyond conventional treatment modalities. Conventional therapies, such as radiation, chemotherapy, and surgery, are hindered by challenges like imprecise targeting, substantial toxicity, and the development of resistance. Exosome-driven nano-immunotherapy has emerged as a groundbreaking approach that leverages the natural properties of exosomes-cell-derived vesicles known for their role in intercellular communication-to deliver therapeutic agents with high precision and specificity.

Chemokines in neurodegenerative diseases.

Neurodegeneration and neuroinflammation disorders are mainly the result of the deposition of various proteins, such as α-synuclein, amyloid-β and prions, which lead to the initiation and activation of inflammatory responses. Different chemokines are involved in the infiltration and movement of inflammatory leukocytes into the central nervous system (CNS) that express chemokine receptors. Dysregulation of several members of chemokines has been shown in the CNS, cerebrospinal fluid and peripheral blood of patients who have neurodegenerative disorders.

Evaluation of bone mineral density and biochemical markers in pediatric patients with phenylketonuria.

Objectives: Phenylketonuria is a hereditary condition caused by the deficiency of the enzyme phenylalanine hydroxylase, leading to abnormal phenylalanine metabolism. Managing phenylketonuria involves implementing dietary interventions to control phenylalanine levels and prevent complications. However, these treatments can lead to long-lasting negative effects, including impacts on bone health and abnormal biochemical test findings.

Global prevalence of constipation during pregnancy: a systematic review and meta-analysis.

Background: Constipation is a common complication and an unpleasant experience during pregnancy. Due to hormonal factors, intestinal movements decrease during this time, causing the digestive system to malfunction. This study aims to explore the worldwide prevalence of constipation during pregnancy to prevent and minimize its complications.

Strain echocardiography predictors in patients with concomitant cardiac amyloidosis and aortic stenosis: a cross-sectional study.

Background: Concomitant cardiac amyloidosis (CA) and aortic stenosis (AS) may be mistaken for isolated AS, potentially impacting the treatment strategy and patient's prognosis. Therefore, it is crucial to distinguish between these conditions, as failure to promptly diagnose CA may lead to considerable complications. The aim of this study is to investigate the diagnostic value of strain predictors in patients with concomitant CA and AS compared to isolated AS.

Investigating the relationship between diet quality, lifestyle and healthy eating index with severity and migraine attacks: a cross-sectional study.

Background: Migraine is a disabling neurovascular disorder often associated with comorbidities such as mental health disorders, cardiovascular diseases, and metabolic syndromes. While certain dietary triggers have been identified, the impact of overall diet quality on migraine severity and frequency is not well understood. This study aimed to evaluate the association between diet quality, lifestyle factors, and the Healthy Eating Index (HEI) with migraine severity and frequency.

Systematic review and meta-analysis of the association of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with periodontitis.

Introduction: Recent evidence suggests the relationship between periodontitis and systemic inflammation, which complete blood count can assess (CBC)-derived biomarkers such as neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). We conducted this meta-analysis to evaluate the levels of NLR and PLR of patients with periodontitis compared to those of healthy controls.  METHODS: Web of Science, PubMed, ProQuest, Scopus, and Open Grey were searched for studies published before October 20, 2024, without any limitation on date and language; then, using the random-effects model, we reported a standardized mean difference (SMD) with a 95% confidence interval (CI).

Prevalence of HPV in anal cancer: exploring the role of infection and inflammation.

Anal cancer incidence is rising globally, driven primarily by human papillomavirus (HPV) infection. HPV, especially high-risk types 16 and 18, is considered a necessary cause of anal squamous cell carcinoma. Certain populations like people living with HIV, men who have sex with men, inflammatory bowel disease patients, smokers, and those with compromised immunity face elevated risk.

The Most Common Multi-Drug Resistant Bacteria Associated with Hospital Infections, in Urmia, Iran.

Background & Objective: Hospital-acquired infections (HAIs) are a major healthcare problem in hospitalized patients, especially in developing countries, where they affect millions of patients and cause high mortality rates. This study aimed to investigate multidrug-resistant bacterial strains in NIs at Imam Khomeini University Hospital in Urmia, Iran.

Methods: This cross-sectional study was conducted using a convenience sampling method.

Electrochemical biosensors for depression: Diagnosis and therapeutic monitoring.

Electrochemical biosensors have revolutionized the detection of biomarkers related to depression and the quantification of antidepressant drugs. These biosensors leverage nanomaterials and advanced assay designs to achieve high sensitivity and selectivity for clinically relevant analytes. Key neurotransmitters implicated in depression, such as serotonin, dopamine, and glutamate, can be accurately measured via biosensors, providing insights into the effects of antidepressant treatments on neurotransmission.

Investigating the effect of teaching assistants (TA) on the level of satisfaction of undergraduate anesthesia students with training in the internship unit.

Background: Clinical training in the internship unit is the heart of professional training, and teaching assistants can be considered an essential component in the clinical training program. Therefore the present study was conducted to investigate the effect of teaching assistants (TA) on the degree of satisfaction of undergraduate students of Anesthesia with training in the internship unit.

Materials And Methods: This descriptive-cross-sectional study was conducted in 2023.