8,491 results match your criteria: "Uric Acid Nephropathy"
Hyperuricemic nephropathy is a metabolic disease in which renal uric acid deposition and excretion are impaired due to elevated levels of uric acid in the blood, leading to impaired renal tubule function and chronic renal disease. Hyperuricemic nephropathy is one of the important complications of hyperuricemia, which seriously affects the quality of life and prognosis of patients. The pathogenesis of hyperuricemic nephropathy involves a variety of factors, including: amino acid metabolism disorder, energy metabolism abnormality, increased nucleotide metabolism, lipid metabolism disorder and bile acid metabolism imbalance, REDOX process disorder, cell cycle and apoptosis imbalance, signal transduction and inflammatory response enhancement, and intestinal flora imbalance.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
December 2024
Department Nephrology of Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fujian, China.
Background: Retinol binding protein 4 (RBP4), as a novel adipokine, has been proven to be highly related to insulin resistance, obesity, diabetes, hypertension, hyperuricemia and other metabolic diseases, which are all risk factors for chronic kidney disease (CKD). However, there is a lack of sufficient studies to explore the relationship between RBP4 and CKD, and no reports have described the predictive value of RBP4 for CKD. This study was designed to clarify the relationship between RBP4 and CKD and its potential predictive value.
View Article and Find Full Text PDFJ Clin Endocrinol Metab
December 2024
Section of Epidemiology and Population Health & Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & Children's Medicine Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu Sichuan, 610041, China.
Context: Renal function may play a crucial role in the development of gestational diabetes mellitus (GDM). However, prospective studies on this topic are scarce and the mechanisms remain unclear.
Objective: To assess the associations of early-pregnancy renal function with GDM and the mediating role of carnitine metabolites.
J Diabetes Complications
December 2024
Tianjin Medical University General Hospital, People's Republic of China. Electronic address:
Uric acid (UA) is mainly synthesized in the liver, intestine, and vascular endothelium and excreted by the kidney (70 %) and intestine (30 %). Hyperuricemia (HUA) occurs when UA production exceeds excretion. Many studies have found that elevated UA is associated with diabetic microvascular complications (DMC), including diabetic retinopathy (DR), diabetic nephropathy (DN), and diabetic peripheral neuropathy (DPN).
View Article and Find Full Text PDFRen Fail
December 2024
Department of Nephrology, Nantong Hospital to Nanjing University of Chinese Medicine, Nantong Hospital of Traditional Chinese Medicine, Nantong, Jiangsu, China.
Objective: This study was recruited to investigate the role of mitophagy in activating NLRP3 inflammasome in the kidney of uric acid (UA) nephropathy (UAN) rats.
Methods: This study developed a uric acid nephropathy (UAN) rat model divided into five groups: Negative control (NC), UAN model (M), UAN + autophagy inhibitor (3-MA), UAN + lysosome inhibitor (CQ), and ROS scavenger (N-acetylcysteine, N). H&E staining assessed renal structure, ROS levels were measured with 2, 7dichlorofluorescin diacetate, and ELISA measured serum markers (, , cystatin , , , ).
Nutr Metab Cardiovasc Dis
November 2024
Department of Nephrology, General Hospital of Ningxia Medical University, Yinchuan, China. Electronic address:
Background And Aim: To understand the clinical and pathological characteristics of patients with IgA nephropathy (IgAN) complicated by hyperuricemia, and to analyze the time-averaged SUA (TA-SUA) on the prognosis of IgAN.
Methods And Results: A retrospective analysis of 718 IgAN patients with diagnosis confirmed by renal biopsy and follow-up of more than 1 year was performed. At least two serum uric acid (SUA) levels were measured at intervals of 0.
SAGE Open Med Case Rep
December 2024
Department of Pediatric Nephrology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
To report a novel variation in the TRIM8 gene in a Chinese patient who developed focal segmental glomerulosclerosis (FSGS) and neurogenic bladder. Retrospective analysis of the clinical manifestations, laboratory results, renal biopsy results, and genetic data of the patient with FSGS complicated with neurogenic bladder. The patient was a 6-year and 8-month-old Chinese Zang ethnic boy with low-set ears, widely-spaced eyes (inner canthal distance exceeds the 95th percentile of normal inner canthal distance), a small jaw, and a short neck.
View Article and Find Full Text PDFOpen Med (Wars)
December 2024
Department of Nephrology, Shaanxi Provincial Hospital of Traditional Chinese Medicine, No. 4, Xihuamen, Xi'an, Shaanxi, 710003, China.
Kidney Dis (Basel)
December 2024
Department of Nephrology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
Front Pharmacol
November 2024
State key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Introduction: The kidney damage caused by the deposition of uric acid in the kidneys is of urgent need for new treatment drugs due to its complex pathogenesis. (Blume) Miq. Also known as , which has a significant therapeutic effect on hyperuricemia nephropathy (HN), however, the specific mechanism of its action is still unknown.
View Article and Find Full Text PDFJ Ethnopharmacol
December 2024
State Key Laboratory of Functions and Applications of Medicinal Plants & School of Pharmaceutical Sciences, Guizhou Medical University, 6 Ankang Avenue, Guian New District, 561113, Guizhou, China; University Engineering Research Center for the Prevention and Treatment of Chronic Diseases By Authentic Medicinal Materials in Guizhou Province, 6 Ankang Avenue, Guian New District, 561113, Guizhou, China; Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, 6 Ankang Avenue, Guian New District, 561113, Guizhou, China. Electronic address:
Ethnopharmacological Relevance: The seeds of Hovenia acerba water extract (HAW) are used as an edible traditional Chinese medicine to treat diseases related to hyperuricemia (HUA).
Aim Of The Study: To evaluate HAW for its anti-HUA effect and to figure out their underlying mechanisms.
Materials And Methods: The anti-HUA effects were evaluated on a mouse model by testing HAW's effects on the levels of serum uric acid (SUA), the biochemical indicators of liver and kidney function, and the histology of liver and kidney.
Front Endocrinol (Lausanne)
December 2024
Nephropathy Center, The Alliated Jiangmen Traditional Chinese Medicine (TCM) Hospital of Jinan University, Jiangmen, China.
Arch Esp Urol
November 2024
Department of Urology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, 05355 Seoul, Korea.
Arch Gerontol Geriatr
November 2024
State Key Laboratory for Innovation and Transformation of Luobing Theory, Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. Electronic address:
Background: Older adults experience numerous physiological and socioeconomic changes that increase the risk of chronic diseases. The uric acid to high-density lipoprotein cholesterol ratio (UHR) has emerged as a potential biomarker for assessing various health conditions. This study aimed to investigate the relationship between UHR and the prevalence of age-related diseases and mortality in a nationally representative sample of older adults in the United States.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
December 2024
National Health Commission (NHC) Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
J Diabetes Complications
January 2025
Department of Internal Medicine, University Hospital Clementino Fraga Filho, School of Medicine; Universidade Federal do Rio de Janeiro, Brazil.
Aims: To investigate the associations between baseline/changes in serum uric acid (sUA) and the risks for cardiovascular/microvascular outcomes and mortality in a type 2 diabetes cohort.
Methods: Baseline sUA was measured in 685 individuals, and 463 had a second sUA measurement during follow-up; sUA was analyzed as a continuous variable and categorized into sex-specific tertile subgroups and low/high levels (>4.5 mg/dl women; >5.
Arch Immunol Ther Exp (Warsz)
January 2024
Department of Transplantology, Immunology, Nephrology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
Int Urol Nephrol
November 2024
Department of Nephrology, The Ninth Medical Center of Chinese PLA General Hospital (Former Name: The Chinese PLA Strategic Support Force Medical Center), Beijing, 100101, China.
J Agric Food Chem
December 2024
Department of Human Nutrition, College of Public Health, Qingdao University, Qingdao 266071, P. R. China.
Medicina (Kaunas)
October 2024
Department of Pathophysiology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Nefrologia (Engl Ed)
December 2024
Servicio de Reumatología, Hospital Universitario Infanta Leonor, Madrid, Spain.
Background: One in 10 patients with hyperuricemia may develop gout over time, with urate deposition sometimes asymptomatic. Recent reviews and guidelines support ultrasound (US) to assess asymptomatic hyperuricemic (AH) patients to detect gout lesions, showing double contour (DC) and tophus the highest specificities and positive predictive values. Hyperuricemia and gout are common in chronic kidney disease (CKD), especially with glomerular filtration rate (GFR) <60, and both are associated with worse prognosis, although treatment of AH in CKD is not yet recommended in all guidelines.
View Article and Find Full Text PDFZhonghua Wei Zhong Bing Ji Jiu Yi Xue
October 2024
Department of Emergency, the Affiliated Hospital of Jining Medical University, Jining 272100, Shandong, China.
Objective: To explore the risk factors of septic acute kidney injury (sAKI) in patients with sepsis, construct a predictive model for sAKI, verify the predictive value of the model, and develop a dynamic nomogram to help clinical doctors identify patients with high-risk sAKI earlier and more easily.
Methods: A cross-sectional study was conducted. A total of 245 patients with sepsis admitted to intensive care unit (ICU) of the Affiliated Hospital of Jining Medical University from May 2013 to November 2023 were enrolled as the research subjects.
Ren Fail
December 2024
Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Background: Renal hypoxia and ischemia significantly contribute to chronic kidney disease (CKD) progression, underscoring the need for noninvasive quantitative assessments. This study employs blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) and arterial spin labeling (ASL) MRI to comprehensively evaluate renal oxygenation and blood flow in CKD patients.
Methods: Forty-two CKD patients across stages 1-5 and ten healthy volunteers underwent simultaneous BOLD-MRI and ASL-MRI.
Food Funct
December 2024
Nutrition and Food Sciences Department, Food Industries and Nutrition Institute, National Research Centre, Dokki 12622, Cairo, Egypt.
Formation of kidney stones is considered a major global problem. Diet plays an important role in the management of kidney stone formation. The main goal of the present research was to evaluate the protective role of fruit and vegetable mixtures as models of an alkaline diet on formation of kidney stones in rats and to conduct molecular docking study.
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