Life style intervention in moderately overweight individuals is associated with decreased levels of cathepsins L and S in plasma.

Background: Adipose tissue cells produce cathepsins L and S, which have proatherogenic effects. Obesity is strongly linked to atherogenesis, cardiovascular morbidity, and mortality.

Objective: The aim of the present study was to see if life style interventions/weight reduction could decrease cathepsin L and S levels in blood plasma.