214 results match your criteria: "Uppsala University: Uppsala Universitet[Affiliation]"

Introduction: Premenstrual dysphoric disorder (PMDD) is a cyclic mood disorder affecting around 2%-5% of women of reproductive age. Pharmacological interventions exist, but many patients with PMDD experience residual symptoms, discontinue medications or refrain from them due to side effects. Thus, non-pharmacological treatments are needed as an alternative or additive treatment strategy.

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Introduction: In Europe, disparities exist in having access to optimal neonatal care. With the European Standards of Care for Newborn Health (ESCNH), evidence-based reference standards are available which provide guidance to improve the care for preterm and ill newborns. To support healthcare professionals (HCPs) and hospital/clinic management in identifying the extent of ESCNH implementation, a feasible assessment tool is required.

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Introduction: Previous population-based studies, mainly from high-income countries, have shown that a higher forced vital capacity (FVC) is associated with a lower risk of developing cardiometabolic diseases. The aim of this study was to assess the longitudinal association between spirometry measures and the onset of cardiometabolic diseases across sites in low-income, middle-income and high-income countries.

Methods: The study population comprised 5916 individuals from 15 countries participating in the Burden of Obstructive Lung Disease baseline and follow-up assessments.

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Objectives: The objective of this study was to assess the completeness of registration of secondary preventive variables comparing on-site visits with telephone consultations during follow-up after myocardial infarction.

Design: This was an observational study based on the Swedish quality registry SWEDEHEART.

Setting And Outcome Measures: We analysed the proportion of missing values for major secondary preventive target data registered at the 2-month and 1-year follow-up visits, during 2006-2022 (n=101 199).

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This study investigated how children's punishment affective states change over time, as well as when children begin to prioritise intentions over outcomes in their punishment decisions. Whereas most prior research sampled children from Anglo-America or Northwestern Europe, we tested 5- to 11-year-old children from Colombia and Spain ( = 123). We focused on punishment behaviour in response to ostensibly real moral transgressions, rather than punishment recommendations for hypothetical moral transgressions.

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Background: Children and young people (CYP) with primary brain tumour (PBT) are at high risk for developing late effects, potentially affecting long-term quality of life (QoL). In low-income and middle-income countries, QoL has not been studied in depth in CYP. In the present study, CYP treated for PBTs in Pakistan were evaluated regarding (A) mean change in QoL scores pretreatment and 12 months post-treatment and (B) predictors of change in QoL scores 12 months post-treatment.

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[The role of EEG in tomorrow's medicine].

Lakartidningen

November 2024

forskare och universitetslektor, institutionen för informationsteknologi, Uppsala universitet; Institute for Systems and Robotics, University of Lisbon, Portugal.

There is a breathtakingly rapid development in various areas that take advantage of the ever-improving possibilities to record and analyze the electrical activity generated in the brain. In this article, we attempt to briefly describe some of these areas, including AI-assisted EEG interpretation, the use of BCI (brain-computer interface) in a medical setting, and the possible new applications connected to the development of very small wearable EEG devices. Furthermore, we discuss the concerns and challenges presented by these advancements in neurotechnology.

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A unique symbiosome in an anaerobic single-celled eukaryote.

Nat Commun

November 2024

Institute for Comparative Genomics, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada.

Symbiotic relationships between eukaryotes and prokaryotes played pivotal roles in the evolution of life and drove the emergence of specialized symbiotic structures in animals, plants and fungi. The host-evolved symbiotic structures of microbial eukaryotes - the vast majority of such hosts in nature - remain largely unstudied. Here we describe highly structured symbiosomes within three free-living anaerobic protists (Anaeramoeba spp.

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Rationale: Patients with obesity hypoventilation syndrome (OHS) have high risk of hospitalization, which might be decreased by home mechanical ventilation (HMV).

Objectives: To evaluate annualized hospitalization rate (AHR) and change in AHR in patients with OHS starting home mechanical ventilation (HMV), and explore if there were any difference in AHR by starting HMV acutely or electively.

Methods: Population-based longitudinal study of patients with OHS starting HMV in the Swedish DISCOVERY cohort between 1996 and 2018, cross-linked with the National Patient Registry for national data on hospital admissions.

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Trust encourages members of communities to cooperate and provide public goods. However, the literature has yet to fully investigate how high and low trusting communities deal with collective action dilemmas with multiple solutions. The latter may raise the risk of coordination failure.

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Background: Access to sample-level metadata is important when selecting public metagenomic sequencing datasets for reuse in new biological analyses. The Standards, Precautions, and Advances in Ancient Metagenomics community (SPAAM, https://spaam-community.org) has previously published AncientMetagenomeDir, a collection of curated and standardised sample metadata tables for metagenomic and microbial genome datasets generated from ancient samples.

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Introduction: At times of parental cancer, children's health and well-being are at risk, which is why interventions to support these children have been developed. When developing such interventions, engagement of the population under study in research is endorsed to enhance relevance of research questions and to enhance uptake and dissemination of the findings. Since no previous review has mapped the ways children participate in the development, use and evaluation of these support interventions, the focus of the upcoming scoping review is to identify gaps in the literature for guidance of future research.

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The high diversity and global distribution of heterotrophic bacterial diazotrophs (HBDs) in the ocean has recently become apparent. However, understanding the role these largely uncultured microorganisms play in marine N fixation poses a challenge due to their undefined growth requirements and the complex regulation of the nitrogenase enzyme. We isolated and characterized Thalassolituus haligoni, a member of a widely distributed clade of HBD belonging to the Oceanospirillales.

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Stridulation is used by male katydids to produce sound the rubbing together of their specialised forewings, either by sustained or interrupted sweeps of the file producing different tones and call structures. There are many species of Orthoptera that remain undescribed and their acoustic signals are unknown. This study aims to measure and quantify the mechanics of wing vibration, sound production and acoustic properties of the hearing system in a new genus of Pseudophyllinae with taxonomic descriptions of two new species.

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Introduction: Rare diseases (RDs) collectively impact over 30 million people in Europe. Most individual conditions have a low prevalence which has resulted in a lack of research and expertise in this field, especially regarding genetic newborn screening (gNBS). There is increasing recognition of the importance of incorporating patients' needs and general public perspectives into the shared decision-making process regarding gNBS.

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Article Synopsis
  • An international survey was conducted across 560 neonatal intensive care units (NICUs) in 24 European countries to assess the usage of lung ultrasound (LU), revealing significant variability in adoption rates (20%-98%).
  • Most NICUs (76%) use LU for clinical reasons, primarily to diagnose respiratory issues and manage acute conditions.
  • Key barriers to LU implementation include lack of experience in technical skills and image interpretation, with suggestions for improvement involving specific training courses and a standardized international guideline.
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Objective: Depression and anxiety are major public health problems. This study evaluated the effects of internet-delivered transdiagnostic psychological treatments for individuals with depression, anxiety, or both.

Design: Systematic review with meta-analysis.

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Antihypertensive, lipid-lowering, and blood glucose-lowering drugs have slowed down the aging process in animal models. In humans, studies are limited, have short follow-up times, and show mixed results. Therefore, this study aimed to estimate the effects of commonly used medications on functional aging, cognitive function, and frailty.

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Objective: To describe the experiences and opinions of general practitioners (GPs) in England regarding patients having access to their full online GP health records.

Design: Convenience sample, online survey.

Participants: 400 registered GPs in England.

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Introduction: Assessing gestational age accurately is crucial for saving preterm newborns. In low and middle-income countries, such as Pakistan, where access to antenatal ultrasonography (A-USG) is limited, alternative methods are needed. This study evaluated the diagnostic accuracy of foot length (FL) measurement for identifying preterm newborns in rural Pakistan using A-USG as the reference standard.

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Article Synopsis
  • The Human Proteome Project (HPP), launched in 2010 by the Human Proteome Organization (HUPO), aims to identify all human proteins and integrate proteomics into studies of health and disease.
  • As of April 2023, 93% of predicted proteins from the human genome have been detected, demonstrating significant advancements in the creation of a comprehensive protein parts list.
  • The project is now transitioning to a Grand Challenge Project that focuses on understanding the functions of these proteins and their roles within biological networks and pathways.
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Challenges and recommendations for addressing under-five pneumonia morbidity and mortality in Nigeria.

Afr Health Sci

June 2023

Norges Teknisk Naturvitenskapelige Universitet Institutt for Samfunnsmedisin, Institute of Public Health. and Nursing; Uppsala Universitet, women's and Children's Health.

Background: Pneumonia is a severe infection and one of the most common causes of mortality among children under five years of age, when not appropriately managed. Infection of the lungs by bacteria, viruses, or fungi and consequent inflammation may lead to cough and difficult breathing. Some of the key predisposing factors are malnutrition and air pollution.

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