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Development of a respirometric biochip for embryo assessment.

Lab Chip

November 2006

Biochemistry Department, Analytical and Biological Chemistry Research Facility, Cavanagh Pharmacy Building, Universlty College Cork, Cork, Ireland.

A prototype respirometric biochip dedicated to monitoring oxygen consumption of preimplantation embryos has been developed. The biochip comprises a linear array of eight flow-through microchambers profiled on silicon substrate, and functions together with a phosphorescent oxygen sensitive probe and fluorescence plate reader detection. A high level of sensitivity to changes in dissolved oxygen was achieved through miniaturisation and optimization of biochip geometry, and incorporation of appropriate sealing and humidification systems.

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