4 results match your criteria: "Universityof California-Los Angeles[Affiliation]"

Is it time to move beyond lymph node evaluation in the staging of colon cancer?

Arch Surg

September 2010

California Oncology Research Institute, David Geffen School of Medicine, Universityof California-Los Angeles, 2336 Santa Monica Blvd., Los Angeles, CA 90404, USA.

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Functional expression of SGLTs in rat brain.

Am J Physiol Cell Physiol

December 2010

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, Universityof California Los Angeles, California 90095-1751, USA.

This work provides evidence of previously unrecognized uptake of glucose via sodium-coupled glucose transporters (SGLTs) in specific regions of the brain. The current understanding of functional glucose utilization in brain is largely based on studies using positron emission tomography (PET) with the glucose tracer 2-deoxy-2-[F-18]fluoro-D-glucose (2-FDG). However, 2-FDG is only a good substrate for facilitated-glucose transporters (GLUTs), not for SGLTs.

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The mammalian securin, pituitary tumor-transforming gene (PTTG), is overexpressed in several tumors and transforms cells in vitro and in vivo. To test the hypothesis that PTTG overexpression causes aneuploidy, enhanced green fluorescent protein (EGFP)-tagged PTTG (PTTG-EGFP) was expressed in human H1299 cancer cells (with undetectable endogenous PTTG expression) and mitosis of individual live cells observed. Untransfected cells and cells expressing EGFP alone exhibited appropriate mitosis.

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